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Analysis of higher cortical function using transcranial magnetic stimulation

Research Project

Project/Area Number 07409012
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 広領域
Research InstitutionThe University of Tokyo

Principal Investigator

SUGISHITA Morihiro  University of tokyo, Faculty of Medicine, Prof, 医学部, 教授 (10114513)

Co-Investigator(Kenkyū-buntansha) TAKAYAMA Yoshihiro  University of tokyo, Faculty of Medicine, Lecturer, 医学部, 講師 (20250201)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsrepetitive magnetic stimulation / magnetic stimulation / higher cortical function / eye mouement / language / vision
Research Abstract

Experiment 1
Discrete steps of the target induce apparent motion sensation. This phenomena is called beta-motion. Recent studies showed that motion perception was processed at V5 which was at the junction of temporal and occipital lobes. To investigate whether beta-motion is related to V5, we applied repetitive transcranial magnetic stimulaiton to V5 while the subjects experienced beta-motion sensation. As a result, we could not find any effect on beta-motion sensation.
Experiment 2
A hypothesis says that motion aftereffect occurs because of the fatigue of visual-related neurons. Some studies with repetitive transcranal magnetic stimulation indicate that repetitive stimulation reduce the threshold of neuronal activities. If so, repetitive stimulation could have some effect on visual illusion when it was applied to illusion-related region. To investigate this hypothesis, we applied repetitive transcranial magnetic stimulation to the parietal lobe, the temporal lobe, the occipital lobe. How … More ever, we could not induce any effects on motion aftereffect.
Experiment 3
When we read a letter, it is assumed that the inlet of the brain is the occipital lobe and the out-let is the frontal lobe. To ascertain this, we applied repetitive transcranial magnetic stimulation to the left frontal lobe when the subject tried to read out one Kana character and measured the reaction time. We found the tendency of delay of reaction time when the stimulation applied 100msec after the visual presentation of a character.
We planned to apply repetitive transcranial magnetic stimulation, because single stimulation is reported to be difficult to induce any effects on higher cognitive function. Our experiment also have failed to induce prominent effect. One reason might be the weakness of the applied stimulation. It was reported thatrepetitive transcranial magnetic induced generalized seizure. As there is no strict criteria of repetitive transcranial magnetic stimulation, we hesitated to apply stronger stimuli. To use this technique further, it is essential to establish the safety criteria. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 杉下守弘、高山吉弘: "磁気刺激による視覚認知へのアプローチ" 神経研究の進歩. 39. 656-661 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉下守弘: "神経心理学の研究法-今後の発展に向けて-" 神経心理学. 11. 10-16 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉下守弘、他: "連続磁気刺激法による言語優位半球の決定" 臨床神経学. 36(1). 216 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 高山吉弘、杉下守弘: "連続磁気刺激による、一次感覚野における時間分解能の検討" 臨床神経学. 36(1). 135 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉下守弘、橋田浩一、他編: "岩波講座・認知科学7.言語/言語脳内メカリズム" 岩波書店, 193(47) (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 高山吉弘: "現代のエスプリ/磁気で脳を刺激する" 至文堂, (8) (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Sugishita and Y.Takayama: "Transcranial magnetic stimulation in Visual neuroscience" Advances in Neuroscience. 39. 656-661 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Sugishita: "Methodological Issued in Neuropsychology : Toward Future Aduansements" Japanese Journal of Neuropsychology. 11 (1). 10-16 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Sugishita et al.: "Determination of language dominance, using repetitire transcranial magnetic stimulation." Japanese Journal of clinical Neurology. 36 (1). 216 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Takayama and M.Sugishita: "Time resolution of the primary somatosensory area by repetitive transcranial magnetic stimulation." Japanese Journal of clinical Neurology. 36 (1). 135 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 杉下守弘、他: "連続磁気刺激法による言語優位半球の決定" 臨床神経学. 36(1). 216 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高山吉弘、杉下守弘: "連続磁気刺激による、一次感覚野における時間分解能の検討" 臨床神経学. 36(1). 135 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 杉下守弘、高山吉弘: "神経研究の進歩" 磁気刺激による視覚認知へのアプローチ, 5 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高山吉弘: "現代のエスプリ" 磁気で脳を刺激する, 8 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 杉下守弘・高山吉弘: "磁気刺激による視覚認知へのアプローチ" 神経研究の進歩. 39. 656-661 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉下守弘: "神経心理学の研究法-今後の発展に向けて-" 神経心理学. 11. 10-16 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] (分担)杉下守弘,橋田浩一他編: "言語の脳内メカニズム(岩波講座・認知科学7・言語)" 岩波書店, 193(47) (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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