| Project/Area Number |
07454168
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Science University of Tokyo |
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Principal Investigator |
SOAI Kenso Science University of Tokyo, Faculty of Science, Professor, 理学部, 教授 (90147504)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
|
| Budget Amount *help |
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1996: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1995: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Keywords | Asymmetric autocatalysis / Dialkylzinc / Asymmetric automultiplication / Asymmetric replication / Pyrimidyl alkanol / Quinolyl alkanol / Asymmetric synthesis / 自己増殖 / 不斉自己触媒反応 / 不斉アルキル化反応 / ピリミジルアルコール / キノリルアルコール |
|---|
| Research Abstract |
Asymmetric autocatalytic reaction of 2-methyl-1- (5-pyrimidyl) -1-propanol (1) was examined. (S) -1 with high e.e.worked as an asymmetric autocatalysis in the reaction of pyrimidine-5-carbaldehyde and diisopropylzinc to afford (S) -1 with high e.e. When (S) -1 with low e.e.was employed as an asymmetric autocatalyst, the newly formed (S) -1 had an higher e.e. By using the newly formed (S) -1 as the asymmetric autocatalyst for the next reaction, the e.e. of (S) -1 reached 90%e.e. Quinolyl alkanol is also an asymmetric autocatalysis to afford itself with 94% e.e.in the reaction of quinoline-3-carbaldehyde and diisopropylzinc.
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