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Design and Evaluation of Novel Selenium-Containing Antioxidant

Research Project

Project/Area Number 07455352
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 有機工業化学
Research InstitutionUniversity of Tokyo

Principal Investigator

NIKI Etsuo  University of Tokyo, Research Center for Advanced Science and Technology, Professor, 先端科学技術センター, 教授 (20011033)

Co-Investigator(Kenkyū-buntansha) NOGUCHI Noriko  University of Tokyo, Research Center for Advanced Science and Technology, Resear, 先端科学技術センター, 助手 (40198578)
YAMAMOTO Yorihiro  University of Tokyo, Research Center for Advanced Science and Technology, Associ, 先端科学技術センター, 助教授 (60134475)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥4,300,000 (Direct Cost: ¥4,300,000)
Keywordsantioxidant / lipid peroxidation / free radical / oxidative damage / selenium / peroxide / ebselen / エブセレン
Research Abstract

There is now increasing evidence which shows that the free-radical mediated oxidations proceed in vivo as in plastics rubber and lipids and that they play a causative role in the progression of various diseases, cancer and aging. As a consequence, the inhibition of such oxidations and development of novel potent antioxidants have received much attention. The present research has been carried out aiming at developing a novel selenium-containing antioxidant and evaluating its antioxidant potency. Ebselen, 2-phenyl-1,2-benzisoselenazol-3 (2H) -one, was chosen as a candidate and its antioxidant action and activity were studied. It was confirmed that ebselen did not act as a radical scavenger nor did it reduce vitamin E radical to regenerate vitamin E.Ebselen reduced hydroperoxides rapidly to corresponding alcohol and thereby inhibited the metal-catalyzed oxidations of lipids and low density lipoproteins. Furthermore, it was found that ebselen completely inhibited the lipid oxidation induce by lipoxygenase. Ebselen also exerted potent antioxidant activity against lipid peroxidation induced by peroxynitrite. It was concluded that ebselen is a potent antioxidant against oxidations induced by metal ions and peroxynitrite.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Y.Yamamoto,et al.: "Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one(MCI-186)" Redox Report. 2. 333-338 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamamoto,Y.Nagata: "Oxidation of human plasma initiated with water-and lipid-soluble radical initiators." J.Jpn.Oil Chem.Soc.45. 445-452 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Sakai,Y.Yamamoto,et al.: "Phospholipase A_2 activity in non-glycated and glycated low density lipoproteins." Biochim.Biophys.Acta. 1301. 85-89 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamamoto,Y.Nagata,et al.: "Rat plasma free fatty acids composition under oxidative stress induced by carbon tetrachloride:decrease of polyunsaturated fatty acids and increase of palmitolec acid" Redox Report. 2. 121-125 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Noguchi,H.Sakai,et al.: "Inhibition of oxidation low density lipoprotein by troglitazone." Atherosclerosis. 123. 227-234 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Nagata,Y.Yamamoto,et al.: "Reaction of phosphatidylcholine hydroperoxide inhuman plasma:The role of peroxidase and lecithin:Cholesterol acyltransferase." Arch.Biochem.Biophys.329. 24-30 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山本順寛: "フリーラジカルと臨床" 日本医学館,東京, 102 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Niki,M.Oikawa,M.Takahashi: "Free Radicals in Brain Physiology and Disorders" Academic Press,San Diego,CA., 474 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Nagata, Y.Yamamoto, and E.Niki: "Reaction of phosphatidylcholin hydroperoxide inhuman plasma : The role of peroxidase and lecithin : Cholesterol acyltrandferase." Arch.Biochem.Biophys.329. 24-30 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Urakami, K.Sugamura, and E.Niki: "Characterization of imidazophyrroloquinoline compounds synthesized from coenzyme PQQ and various amino acids." BioFactors. 5. 75-81 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Noguchi, H.Sakai, Y.Kato, J.Tsuchiya, Y.Yamamoto, E.Niki, and H.Horikoshi: "Inhibition of oxidation low density lipoprotein by troglitazone." Atherosclerosis. 123. 227-234 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Urakami, A.Tanana, T.Tanimoto, E.Niki: "Synthesis and aldose reductase-inhibitory activity of imidazophyrroloquinoline esters." Chem.Pharm.Bull.44. 1493-1497 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Sakai, Y.Yamamoto, N.Baba, and M.Nakano: "Phospholipase A_2 activity in non-glycated and glycated low density lipoproteins." Biochim.Biophys.Acta. 1301. 85-89 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamamoto and Y.Nagata: "Oxidation of human plasma initiated with water- and lipid-soluble radical initiators." J.Jpn.Oil Chem.Soc.45. 445-452 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamamoto, T.Kuwahara, K.Watanabe, and K.Watanabe: "Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)" Redox Report. 2. 333-338 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Urakami, A.Tanaka, K.Yamaguchi, T.Tsuji, and E.Niki: "Synthesis of esters of coenzyme PQQ and IPQ,and stimulation of nerve growth factor production." BioFactors. 5. 139-146 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Urakami, C.Yoshida, T.Akaike, H.Maeda, H.Nishigori, and E.Niki: "Synthesis of monoesters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo." J.Nutr.Sci.Vitaminol.43. 19-23 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Yamamoto,etc.: "Antioxidant activity of 3-methl-1-phenyl-2-pyrazolin-5-one(MCI-186)" Redox Report. 2,. 333-338 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Yamamoto,Y.Nagata: "Oxidation of human plasma initiated with water-and lipid-soluble radical initiators." J.Jpn.Oil Chem.Soc.45. 445-452 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Sakai,Y.Yamamoto,etc.: "Phospholipase A_2 activity in non-glycated and glycated low density lipoproteins." Biochim.Biophys.Acta. 1301. 85-89 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Yamamoto,Y.Nagata,etc.: "Rat plasma free fatty acids composition under oxidative stress induced by carbon tetrachloride:decrease of polyunsaturated fatty acids and increase of palmitoleic acids." Redox Report. 2. 121-125 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Noguchi,H.Sakai,etc.: "Inhibition of oxidation low density lipoprotein by troglitazone." Atherosclerosis. 123. 227-234 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Y.Nagata,Y.Yamamoto,etc.: "Reaction of phosphatidylcholine hydroperoxide inhuman plasma:The role of peroxidase and lecithin:Cholesterol acyltransferase." Arch.Biochem.Biophys.329. 24-30 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山本順寛: "フリーラジカルと臨床" 日本医学館,東京, 102 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] E.Niki,M.Oikawa,M.Takahashi: "Free Radicals in Brain Physiology and Disorders" Academic Press,San Diego,CA., 474 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Gotoh,N.Noguchi,et al.: "Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds." Free Rad.Res.24. 123-134 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] E.Niki,N.Noguchi, et al.: "Interaction among vitamin C,Vitamin E,and β-carotene." Am.J.Clin.Nutr.,. 62(Suppl). 1322S-1326S (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Tsuchihashi,E.Niki,et al.: "Action of β-carotene as an antioxidant against lipid peroxidation." Arsh. Biochem.Biophys.323. 137-147 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Hayashi,E.Niki,et al.: "Action of nitric oxide as an antioxidant against oxidation of soybean phosphatidylcholine liposomal membranes." FEBS Lett.370. 37-40 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] N.Noguchi,E.Niki: "Dynamics of free radical formation from the reaction of peroxides with haemproteins as studied by stopped-flow chemiluminescence." Free Rad.Res.23. 329-338 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Yasuda,E.Niki,et al.: "Hepatic damage induced by perfusion of radical generating azo compound and its inhibition by vitamin E." Chem.Biol.Inter.97. 11-23 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Ohya-Nishiguchi L.Packer: "Bioradicals Detected by ESR Spectroscopy" Birkhauser Verlag Basel,Switzerland, 337 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.S.Ong,E.Niki L.Packer: "Nutrition,Lipids,Health,and Disease" AOCS Press,Champaign,IL, 374 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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