| Project/Area Number |
07456128
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Masayuki Hokkaido Univ., Graduate Sch.of Vet.Med., Professor, 大学院・獣医学研究科, 教授 (80036441)
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| Co-Investigator(Kenkyū-buntansha) |
森松 正美 北海道大学, 大学院・獣医学研究科, 助手 (70241370)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1996: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1995: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | stress / Lymphocytes / Sympathetic nervous system / Cytokines |
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| Research Abstract |
Various types of stressor suppress immune activities. Previously, we have confirmed a significant role of the sympathetic nervous system (SNS) in the stress-induced immunosuppression. In this study, we examined the effects of brain stimulation on the sympathetically mediated immunosuppression in rats. When the ventromedial hypothalamus (VMH), a putative hypothlamic center linked to the SNS,was stimulated electrically, the proliferative activity of splenic lymphocytes was reduced. The suppressive effect of VMH was not affected by adrenalectomy, but abolished by ganglionic blockade and surgical sympathetic denervation. These results suggest a critical role of the VMH in the stress-induced immunosuppression. Similar suppressive effects were also observed when interleukin-1 (IL-1), a representative cytokine produced in immune cells and brain cells, was given intracerebroventricularly. Brain IL-1 was also found to accelerate noradrenaline turnover in various peripheral organs, implying increased activity of the SNS.There are reports that the stress-induced immunosuppression was attenuated by intracranial injection of anti-IL-1 antibody. Collectively, it was concluded that brain IL-1 and the VMH play important roles in the stress-induced immunosuppression.
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