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Study and gene ralization of "Oscillator and gate operators model" in vasomotor center

Research Project

Project/Area Number 07457012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

NINOMIYA Ishiro  Hiroshima Univ.Sch.of Med.Proffessor, 医学部, 教授 (80033976)

Co-Investigator(Kenkyū-buntansha) FURUKAWA Kazuto  Hiroshima Univ.Sch.of Med.Research Associate, 医学部, 助手 (70263704)
SHIMIZU Junichi  Hiroshima Univ.Sch.of Med.Associat Proffessor, 医学部, 助教授 (10126584)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥3,300,000 (Direct Cost: ¥3,300,000)
KeywordsSymputhetic nerve activity / rat, cat, swine / cardiovasomotor center / oscillator / gate operators / fundcemental rlythm / オッシレーター / ラットとミニブタ / 基本リズム
Research Abstract

To examine our "oscillater and gate operator model" aortic pressure, aotic nerve activity, cardiac sympathetic nerve activity (CSNA) and ECG were measured Simultaneously during rest and exercise in conscious freely-moving cuts and separately in anesthetized rats (BW : 0.2-0.4kg), cats (2-4kg) and swines (20-50kg). Periodicity, peak neight and width of synchronized CSNA and renal sympathetic nerve activity (RNA) were analyzed by the cluster program and the delay time of synchronized CSNA and RNA from the R wave of ECG was measured The interval histograms show two modes consisting 8-12Hz (Tc) and cardiacrelated (Tb) rlythms. The modes of Tc rlythm were almost the same in all of the rats, cats and swines whereas the modes of Tb rlythm changed depending on the cardiac intervals. The Tc rlythm (8-12Hz) did not influeced by baroceptor input, heart rate and chemoreeptor inputs. The results indicate that the Tc rlyth is the common fundameutal rlythm of central origin and is independent of the size of neural network and body weight. The probability of synchrouized RNA was maximum at delouy time of 50ms and 180ms in the rats and swines, respectirely, and then deveused rapidly near Zero due to pulsatile beroceptor input. These results suggest that the gate operators oppened at the maxim probability while it closed at the minimum probubility.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Ninomiya,I.: ""Oscillator and gate operator model" for faroceptor reflex system in conscious cats" Japanease J.Physiology. 46. S45 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsukawa,K: "The 24-hour distribution of sympathetic nerve activity to the heart and the Kidney in conscious freely-moving cats." FASEB Journal. 10. A334 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsukawa,K: "Changes in cardiac sympathetic efferent nerue activity,heart rate,and artevial blood pressure associated with voluntary behavior in conscious freely-moving cats" Japanease J.Physiology. 46. S38 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu,J.: "Modulation of Somato sensory-renal sympathetic nerve activity reflex in the ishemic foot." Japanease J.Physiology. 46. S165 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa,K.: "Effects of contralateral renal ishemia on renal sympathetic nerve activity in rats." Japanease J.Physioloyg. 46. S163 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa,K.: "Renal sympathetic nerve activity and the weight of the remaining kidney in unilatral nephrectomized rats." J.of the Autonomic Nervous System. 63. 91-100 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ninomiya, I.: ""Oscillator and gate operator model" for faroceptor reflex system in conscious cats" Japanease J.Physiology. 46. S45 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsukawa, K.: "The 24-hour distribution of sympathetic nerve activity to the heart and the kidney in conscious-freely moving cats." FASEB Journal. 10. A334 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsukawa, K.: "changes in cardiac sympathetic effereut nerve activity, heart rate, and arterial blood pressure associated with voluntary behavior in consciousfreely moving cats." Japanease J.Physiology. 46. S38 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, J.: "Modulation of somato sensory-renal symputhetic nerve activity reflex in the ishemic foot" Japanease J.Physiology. 46. S165 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa, K.: "Effects of contralateral renal ishemia on renal sympathetic nerve activity in rats" Japanease J.Physiology. 46. S163 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Furukawa, K.: "Renal sympathetic nerve activity and the weight of the remaining Kidney in unilateral nephredomized rats." J.of the Autonomic Nervous System. 63. 91-100 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ninomiya, I: "″Oscillator and gate operators model″ for baioceptor reflex system in conscisus cats." Japanease J. Physiology. 46. S45 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsukawa, K,: "The 24-hour distrifution sympathetic yerve activty to the heart and the kidn" FASEB Journal. 10. A334 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsukawa, K.: "Changes in cardiac sympathetic effevent nerveaetivity, heantrall, and arterial blood pressure associated with voluntary behavior in consctous fneely whoing cat" Japanease J. Physiology. 46. S38 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu, J.: "Modulation of somatosensory-venal sympathetic nerve activity reflex in the ishemic foot." Japanease J. Physiology. 46. S165 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Furukawa, K.: "Effects of contralateral venal ishemia on renal sympathetic nerve activity in rats." Japanease J. Physiology. 46. F163 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Furukawa, K.: "Renal sympathetic nerve activity and the weight of the remaining kiding in unilateral uephrectouizod rats," J. of the Autonomic Nervous Syotem. 63. 91-100 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ninomiya,I: "Common fundamental rleythm of renal sympathetic nerve activity in rats, Cats and swine" Japanease J Physiology. 45. 203 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Matsukawa, K.: "Sympathetic nervous control of candiac excitation rlythm over a 24-hour period in aweke cats" Japanese J Physiology. 45. 64 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yonezawa, Y: "A new detection method of synchronized sywpashetic nerve activity." Engineering & Phisics in Medicine. Pr. 210 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Okamura, S: "A new segmentation wethad of Synchronized Sywpathetic nerve activity" The 17th Ann International Conb of the IEEE/EMB. Pr.98 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hedman, A. E.: "Periodicity, anptitude and width of synchnouijod candiac sympath nerve activity in anesthetizad cats" J. Auton, Nerv, Syot. 55. 81-91 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shirai M.: "Changes in efferent pulmonary sympathetic nerve activity during systemic bypoxia in anesthetizod cats" Am, J. Physiology. 38. R1404-R1409 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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