| Project/Area Number |
07457038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of East Asia (1997)
Kyoto University (1995-1996) |
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Principal Investigator |
NARA Yasuo University of East Asia, Professor, 工学部, 教授 (80116417)
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| Co-Investigator(Kenkyū-buntansha) |
SAWAMURA Makoto Graduate School of Human and Environmental Studies, Kyoto University, Senior Res, 大学院・人間環境学研究科, 助手 (00187303)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1997: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1996: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | linkage aralysis / microsatellite / salt-sensitive hypertension / stroke-prone SHR / 連鎖分析 / マイクロサテライト / ウイスター京都ラット |
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| Research Abstract |
We in vestigated candidated loci for salt-sensitive high blood pressure in F2 progeny from crossing Wistar Kyoto and stroke-prone spontaneously hypertensive rats. Average systolic blood pressure in male F2 progeny was 10mmHg higher than that of female F2 progeny at 5 months without salt loading. The blood pressure in male F2 progeny was raised significantly 2 months after salt loading, but there was no further significant change in blood pressure even though salt loading was continued for 5 months. In the female F2 progeny, however, a significant change in systolic blood pressure was observed 1 month after salt loading and there was a further significant rise in blood pressure over 6 months. The candidate locus for salt-sensitive hypertension after salt loading for 7 months in male F2 progeny was mapped on chromosome 10 but not the female F2 progeny. In female F2 progeny, systolic blood pressure on 12th day and seventh month after salt loading was strongly linked with hthe D3Mgh12 and D3Mgh6 loci on chromosome 3, respectively. Na-K-2cl cotransporter that plays an important role in ion transport in the kidney was assigned at 2 cM from the D3Mgh 12 locus and significantly linked with systolic blood pressure on 12th day after salt loading.
These results suggest that different gene (s) might be involved in salt-sensitive hypertension between gender.
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