| Project/Area Number |
07457048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORI Shigeo The University of Tokyo, Institute of Medical Science, professor, 医科学研究所, 教授 (30010424)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1996: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1995: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | Malignant lymphoma / Anaplastic large cell lymphoma / chimerie gene / Translocation of chromosome / Hodgkin's disease / ホジキン病 / CD30 / キメラ蛋白 / 染色体 / 転座 |
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| Research Abstract |
Ki-1 lymphoma is a subtyper of human malignant lymphoma comprizing its 2-7%. Whlee the pathogenetic mechanism of Ki-1 lymphoma remained unknown, we noted a novel chimeRic protein p80, composed partly ALK gene on chromosome 2 and partly of nucleophosmin gene on chromosome 5, is highly expressed on 40% of Ki-1 lymphomas. IN the present study, we formed that p80 affects normal signal transduction passway on positive (swutch-on) way at a certain points causing high proliferation of host cells. Also formd the ALK gene to be highly expressed in murine brain, suggesting its normal role on nerve function.
Peculiarly, with the co-operation of oversea groups, we found that p80 is expressed highly in Ki-1 lymphomas but not in Hodgkin's desease that share similar histopathology. It is our conclusion that Ki-1 lymphoma expressing p80 is a unique disease entity in phenotype as well as pathogenesis
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