| Project/Area Number |
07457088
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | KUMAMOTO UNIVERSITY (1996-1997)
Tottori University (1995) |
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Principal Investigator |
SAKAGUCHI Nobuo Kumamoto University, School of Medicine, Professor, 医学部, 教授 (70192086)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1997: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1996: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | pre-B cell / rapamycin / phosphatase / MB-1 / signal transduction / 増殖 / 免疫抑制剤 / PP2A / 抗原レセプター / Igα(MB-1) / α4 / ホスファターゼ / 細胞周期 / 細胞増殖 / pre-B細胞 / 細胞分化 / 胎児 |
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| Research Abstract |
To study the activation and development of immature B lineage cells, we searched the unique signal transduction molecules expressed in the immature B cells or in the process of B cell activation.
We characterized the pre-BCR signal transduction molecules, among which PI-3 kinase activity was shown to be involved in the pre-B cell stages. We also isolated a molecule named immunoglobulin-receptor binding protein (IGBP-1/alpha4) , which is originally identified as a phosphoprotein co-precipitated with the BCR-component MB-1 molecule. The alpha4 gene was isolated and characterized. The recent results also showed that the alpha4 protein is associated with the protein phosphatase 2 A,whose association is critical for the proliferation of B cells. The alpha4/PP2A complex is shown to be a novel target of rapamycin. These results implicated the novel signal transduction pathway involved in the proliferation of lymphoid cells.
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