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Relation between porphyrin-metabolic disorders and some internal factors in lead-exposed subjects

Research Project

Project/Area Number 07457096
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionSaga Medical School

Principal Investigator

TOMOKUNI Katsumaro  Saga Med Sch, Dept Comm Health Sci, Professor, 医学部, 教授 (40032891)

Co-Investigator(Kenkyū-buntansha) ICHIBA Masayoshi  Saga Med Sch, Dept Comm Health Sci, Res.Assoc., 医学部, 助手 (60184628)
HIRAI Yukio  Saga Med Sch, Dept Comm Health Sci, Res.Assoc., 医学部, 助手 (90156638)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥7,300,000 (Direct Cost: ¥7,300,000)
Fiscal Year 1996: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1995: ¥4,900,000 (Direct Cost: ¥4,900,000)
Keywordslead workers / porphyrin-metabolic disorder / delta-aminolevulinic acid / sensibility / sex difference / blood lead / ポリフィリン代謝異常 / コプロポルフィリン / 血液鉛
Research Abstract

To elucidate the relationship between lead-induced porphyrin metabolic disorders and some internal factors, we first investigated whether the response of biological parameters such as plasma delta-aminolevulinic acid (ALA), urinary ALA,and urinary coproporphyrin (CP) differs between male and female workers occupationally exposed to lead.
The biological samples (urine and blood) were obtained from about 300 lead workers (160 males and 138 females). The concentrations (mean<plus-minus>SD) of blood lead (males : 55<plus-minus>13 mug/dl ; females : 55<plus-minus>14mug/dl) indicated that the intensity of occupational exposure to lead was almost equal in the two groups. On the other hand, the elevation of plasma ALA concentration and the increased urine ALA and CP excretions among these lead workers were much higher in females than in males. This data confirms the finding of a sex difference in the biological effect of human exp
Secondly, we determined some biological parameters such as copper, zinc, vitamin E,beta-carotene, and superoxide dismutase (SOD) activity in the blood samples. However, we could not find significant relations between these parameters and the degree of porphyrin metabolic disorders in lead-exposed workers.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 原田幸一: "ポルフィリンとポルフィリン前駆体の動態,代謝,排泄様式" 日本臨床. 53. 1349-1356 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Oishi: "Comparison between males and females with respect to the porphyrin metabolic disorders found in...." Int.Arch.Occup.Environ.Health. 68. 298-304 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Oishi: "Chronic lead exposure may inhibit endothelium-dependent hyperpolarizing factor in rats" J.Cardiovascular Pharmacology. 28. 558-563 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koichi Harada: "Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria" NIHON RINSYO. 53. 1349-1356 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hirotaka Oishi: "Comparison between males and females with respect to the porphyrin metabolic disorders found in workers occupationally exposed to lead" Int Arch Occup Environ Health. 68. 298-304 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hirotaka Oishi: "Chronic lead exposure may inhibit endothelium-dependent hyperpolarizing factor in rats" J Cardiovascular Pharmacol. 28. 558-563 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 原田幸一: "ポリフィリンとポリフィリン前駆体の動態,代謝,排泄様式" 日本臨床. 53. 1349-1356 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Oishi: "Comparison between males and females with respect to the porphyrin metabolic disorders found in workers." Int. Arch.Occup.Environ.Health. 68. 298-304 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Oishi: "Chronic lead exposure may inhibit endothelium-depen-dent hyperpolarizing factor in rats" J.Cardiovascular Pharmacol.28. 558-563 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Oishi: "Fluorimetric HPLC determination of S-aminolevulinic acid (ALA) in the plasma and urine of lead workers : ....." Journal of Analytical Toxicoloqy. 20(in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Oishi: "Comparison between male and female in the porphyrin metabolic disorders found in workers occupationally..." International Archives of Occupational and Environmental Health. (Accepted). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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