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PREDICTION OF CAUSATIVE AGENTS AGAINST OCCUPATIONAL HYPERSENSITIVITY PNEUMONITIS AND DETERMINATION OF THE THRESHOLD LIMIT VALUE

Research Project

Project/Area Number 07457097
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

UEDA Atsushi  KUMAMOTO UNIVERSITY MEDICAL SCHOOL,DEPT.OF HYGIENE,PROFESSOR, 医学部, 教授 (10040198)

Co-Investigator(Kenkyū-buntansha) OMORI Shoko  KUMAMOTO UNIVERSITY MEDICAL SCHOOL,DEPT.OF HYGIENE,ASSISTANT PROFESSOR, 医学部, 助手 (60040193)
HARADA Koichi  KUMAMOTO UNIVERSITY MEDICAL SCHOOL,DEPT.OF HYGIENE,LECTURER, 医学部, 講師 (00094029)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordsoccupational hypersensitivity pneumonitis / occupational allergy / fungi / agricultural medicine / industrial health / experiment of allergenesity / eggplant / alstromeria / 許容濃度 / 反応予測
Research Abstract

1)We conducted to establish an animal experimental model for predictive assessment of an allergenecity of hypersensitivity pneumonitis (HP) against materials born in occupational environment, especially fungi. Finally we adopted for development of HP in the lung tissue of c57Black/6 mice by repeated nasal administration of fungus antigen suspended in distillled water. The test fungus was Fusarium sp. sampled from the plastic greenhous planting eggplants and isolated by purified cultivation.
The treated animals developed typical HP lesions in their lung tissue after total of 5 times exposure for 5 weeks.
The result suggested that the trial model was useful and adequate to detect fungi sp. in the working places showing allergenesity to HP and also demonstrated firstly the allergenesity of HP of Fusarium sp.
2)We made and proposed the flow chart for predictive ditection of allergenesity of HP and it's prevention among materials born in occupational environment, especially in agriculture, including the animal experimental model developed in the present research project.
3)We clarified an immediate type allergenesity of an extract from eggplant component and a delayd type allergenesity of an extract of alstromeria both cultivated in plastic greenhouse and found allergic cases in workers of those cultivations.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 上田 厚: "職業性過敏性肺炎の起因抗原および危険因子の予知に関するモデルの設定" 産業医学. 40(臨時). 713-713 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 原田 幸一: "フサリウム暴露によるマウスの過敏性肺炎に関する研究" 日本衛生学雑誌. 53(1). 227-227 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.UEDA: "Respiratory hazards Among Agricultural Workers" Abstracts,the 9th Conference on Occupational Respiratory Disease.151-151 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 原田 幸一: "アルストロメリア接触皮膚炎の実験的研究" 日本衛生学雑誌. 52(1). 419-419 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 原田 幸一: "アルストロメリア接触皮膚炎のモルモットによる実験的研究" 日本農村医学会雑誌. 46(3). 629-629 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ueda: "Respiratory hazards among agricultural workers." Proceedings of 9th Conference in occupational diseases. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Harada: "Experimental study of contact dermatitis due to Alstromeria in guinea pigs." Contact Dermatitis. (in contributing). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Harada: "A study on hypersensitivity pneumonitis by Fusariumexposure in mice." Jpn.J.Hyg.53. 227 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ueda: "A model for prediction system of a hazard of hypersensitivity pneumonitis." J.Occup.Health. 40(suppl.). 713 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Harada: "Contact dermatitis from alstomeria" Jpn.J.Hyg.52. 419 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Ueda: "Allergy among eggplant cultivators in the plastic greenhouse." Occup.Environ.Allergy. 4. 33 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 上田 厚: "職業性過敏性肺炎の起因抗原および危険因子の予知に関するモデルの設定" 産業医学. 40(臨時)(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 原田 幸一: "フサリウム暴露によるマウスの過敏性肺炎に関する研究" 日本衛生学雑誌. 53(1). 227-227 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.UEDA: "Respiratory Hazards Among Agricultural Workers" Ab stracts, the 9th Conference on Occupational Respiratory Disease.151-151 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 原田 幸一: "アルストロメリア接触皮膚炎の実験的研究" 日本衛生学雑誌. 52(1). 419-419 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 原田 幸一: "アルストロメリア接触皮膚炎のモルモットによる実験的研究" 日本農村医学会雑誌. 46(3). 629-629 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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