| Project/Area Number |
07457112
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | TOKAI UNIVERSITY |
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Principal Investigator |
OKAZAKI Isao TOKAI UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (00051649)
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| Co-Investigator(Kenkyū-buntansha) |
FURUYA Hiroyuki TOKAI UNIVERSITY,SCHOOL OF MEDICINE,INSTRUCTOR, 医学部, 助手 (10276793)
WATANABE Ippei TOKAI UNIVERSITY,SCHOOL OF MEDICINE,INSTRUCTOR, 医学部, 助手 (50147162)
AIKAWA Hiroyuki TOKAI UNIVERSITY,SCHOOL OF MEDICINE,INSTRUCTOR, 医学部, 助手 (40102850)
OSAKA Fumio TOKAI UNIVERSITY,SCHOOL OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (70096204)
WATANABE Tetsu TOKAI UNIVERSITY,SCHOOL OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (10129744)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | cancer screening / 3-hydroxyproline / cancer invasion and metastasis / organ-nonspecific cancer marker / working place / 尿3-hydroxyproline / 検診の有用性 / 職域がん検診 / スクリーニング検査法 / 特異度 / 鋭敏度 |
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| Research Abstract |
Cancer screening for healthy persons at the working places should be performed under the following conditions. (1) Planning and doing should be discussed between industrial physicians and emplyer and emplyees, especially the limitation of cancer screening as well as the handling of private information. (2) The investigators proposed urinary excretion level of 3-hydroxyproline as the first step for cancer screening. This marker has a very unique one indicating tissue breakdown occured in cancer invasion and metastasis, because this amino acid is specific for basement membrane. In this project research the specificity and sensitivity of this marker were 98% and 100%, respectively. (3) According to the positive data of this marker, the second cancer screening should be done by the conventional examination of each organ. However, the target organs should be selected by thr risk factors based on life styles. (4) Finally we prepared the system for cancer screening at working place.
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