| Project/Area Number |
07457169
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shiga University of Medical Sciences |
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Principal Investigator |
IWAI Naoharu Shiga University of Medical Science, 1st Dept of Intern Med, Assist.Profess., 医学部, 助手 (30242978)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1996: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1995: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | renin angiotensin system / hypertrophy / hypertension / molecular genetics / レニン / 遺伝学 / 肥大 |
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| Research Abstract |
1. Tissue renin-angiotensin system and cardiac hypertrophy. We evaluated expression of every component of renin angiotensin system in rat hypertrophied heart induced by aorto-caval shunt. We observed the importance of angiotensin-converting enzyme expressed in the ventricles in the development of hypertrophy in this model. We found that renin was expressed in rat macrophage/monocyte cells infiltraing necrotic myocardium induced by isoproterenol administration. This findning suggests that macrophage may be a source of tissue renin in various pathological conditions.
2. Identification of new genes relevant to the development of cardiac hypertrophy by differential screening. We found that type II tissue transglutaminase was up-regulated in hypertrophied heart. This enzyme has been known to activate latent TGF-beta, which has potent effects on cardiac development.
3. Genetic approach to the identification of new genes relevant to the development of cardiac hypertrophy. We have found that loci in the rat chromosome 1,2 and 8 has significant effects on heart/body weight ratio in F2 population derived from SHR and WKY.The effects of the loci in chromosome 2 and 8 seem to be through the effecs on blood pressure, and the effects of the chromosome 1 locus seem to be through the effects on renal function.
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