| Project/Area Number |
07457188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Tokyo |
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Principal Investigator |
USHIJIMA H. University of Tokyo, Graduate School of Medicine, Prof., 大学院・医学系研究科, 教授 (10091068)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO O. University of Tokyo, Institute of public Health, Chief, 衛生微生物学部, 室長 (40270631)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1997: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | diarrheal virus / rotavirus / small round structured virus / adenovirus / astrovirus / Norwalk virus / molecular epidemiology / アデノウイルス / ノ-ウォークイウルス |
|---|
| Research Abstract |
Death caused by diarrheal viruses were rare in Japan, While, were about 1000,000 wold wide. Many infants have the viruses. 1) Rapid diagnosis by latex agglustination was developed in rotavirus, adenovirus and astrovirus. 2) Diagnosis and serotyping of diarrheal viruses by RT-PCR were developed in diarrheal viruses, especially in astrovirus and SRSV.3) Molecular epidemiological study was conducted for the study of variation in inter- and intra- serotypes. 4) Antirotavirus-candidate substances were seeked for treatment of diarrheal viruses. In these two or three years, SRSVs were detected predominantly in early winter time and rotaviruses were predominantly in later winter time. Afebrile convalsion was recognized in SRSVs serotype 1 of rotavirus, serotype 41 of adenovirus and serotype 1 of astrovirus and, genogroup 2 of SRSVs were predominant in Japna. Within a serotype, different strains were recognized in different places and individuals.
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