STUDY ON THE NON-INVASIVE MEASUREMENT OF OXYGEN CONCENTRATION IN TUMORS BY NEAR-INFRARED LIGHT AND EVALUATION OF ITS OPTICAL CT IMAGING
| Project/Area Number |
07457203
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | TOKAI UNIVERSITY |
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Principal Investigator |
MORI Tomoyuki TOKAI UNIV.SCHOOL OF MEDICINE PROFESSOR, 医学部, 教授 (70055896)
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| Co-Investigator(Kenkyū-buntansha) |
KUTSUZAWA Tomoko SCHOOL OF HEALTH SCIENCE ASSOCIATE PROFESSOR, 健康科学部, 助教授 (10183310)
HAIDA Munetaka SCHOOL OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (20208408)
TAMAI Yoshifumi SCHOOL OF MEDICINE ASSISTAN RESEARCHER, 医学部, 助手 (90207225)
OHIZUMI Yukio SCHOOL OF MEDICINE ASSOCIATE PROFESSOR, 医学部, 助教授 (30024813)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥3,200,000 (Direct Cost: ¥3,200,000)
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| Keywords | NEAR-INFRARED LIGHT / HYPOXIC CELLS / OXYGEN SATURATION / OXY-HEMOGLOBIN / DEOXY-HEMOGLOBIN / CARBOGEN GAS / Oz saturation / Oxy-hemoglobin / Deoxy-hemoglobin / O_2 saturation / Oxy-hemoglohin / Nicotinamide / Carbogen |
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| Research Abstract |
PURPOSE : WE STARTED THE STUDY ON THE HEMOGLOBIN (HB) OXYGEN MAPPING IN TUMORS UNDER VARIOUS CONDITIONS IN BREATHING.THE PURPOSE OF THIS STUDY WAS TO GET A FURTHER DEVELOPMENT USING THREE-WAVELENGTH NEARINFRARED LIGHT TO OBTAIN A RELIABLE OXY-AND DEOXY-HB OR TOTAL HB AND HB O_2 SATURATION MAPPING IN MOUSE TUMOR.M&M : THREE KINDS OF SEMICONDUCTOR PULSE LASER,770NM,808NM AND 854NM,WERE USED AS NEAR-INFRARED LIGHT SOURCES.A PULSE LASER BEAM WAS GUIDE INTO THE TUMOR VIA AN OPTICAL FIBER PUTTING IN THE SURFACE OF THE TUMOR.LIGHT TRANSMITTED THROUGH THE TUMOR WAS DETECTED BY 7 OUT OF 12 OPTICAL FIBERS PLACED ON THE OPPOSITE SIDE FROM THE SOURCE AND GUIDED TO A STREAK CAMERA TO OBTAIN 7 TIME-RESOLVED SPECTRAL DATA SIMULTANEOUSLY.12 TIMES 7 PROJECTION DATA FOR EACH WAVELENGTH WERE USED TO OBTAINED AN IMAGE OF OXY-AND DEOXY-HB DISTRIBUTIONS BY USING A FILTERED BACK-PROJECTION CT IMAGE RECONSTRUCTION METHOD.THE IN VIVO TOTAL HB AND HB O_2 SATURATION IMAGES OF MOUSE TUMOR WERE THEN CALCULATED.RESULTS : IN VIVO HB O_2 SATURATION IMAGES OF MOUSE UNDER THREE BREATHING CONDITIONS COULD BE OBTAINED USING NEAR-INFRARED LIGHT.THE HB O_2 SATURATION OF TUMOR INCREASED BY CARBOGEN INHALATION AND DECREASED BY NO-BREATHING.THE IMAGES EXHIBITED THE EFFECT OF CARBOGEN INHALATION ON TOTAL HB AND ITS O_2 SATURATION DISTRIBUTION FOR TUMORS.THE VARIATION OF HB VOLUME AND HB O_2 SATURATION OF TUMOR AFTER CARBOGEN INHALATION AS A FUNCTION OF TUMOR VOLUME.INCREASING HB VOLUME BY CARBOGEN INHALATION WAS EFFECTIVE TO THE SMALL TUMORS.THE HB O_2 SATURATION OF TUMOR DECREASED BY INCREASING OF THE VOLUME OF TUMOR.ALTHOUGH FURTHER IMPROVEMENT IN THE TECHNIQUE SHOULD RESULT IN BETTER RESOLUTION.WE HAVE DEMONSTRATED THE FEASIBILITY OF USING NEAR-INFRARED LIGHT TO OBTAIN IN VIVO HB O_2 SATURATION IMAGES IN MOUSE TUMOR.
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Report
(4 results)
Research Products
(11 results)
