| Project/Area Number |
07457210
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
MIYAKAWA Taihei Kumamoto University, School of Medicine, Professor, 医学部, 教授 (90040542)
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| Co-Investigator(Kenkyū-buntansha) |
YASUGAWA Setsuko Kumamoto University, School of Medicine, Assistant, 医学部, 助手 (80244119)
YAMASHITA Kensho Kumamoto University, School of Medicine, Assistant, 医学部・附属病院, 助手 (10230418)
KATSURAGI Shoichi Kumamoto University, School of Medicine, Lecturer, 医学部・附属病院, 講師 (00161092)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | Alzheimer's disease / amyloid / senile plaque / neurofibrillary tangle / granulo-vacuolar degeneration / 微小循環 / 神経細胞脱落 / 微小血管 / リポクローム / 星状膠細胞 / 電子顕微鏡 / ミクログリア / アポリポ蛋白 / タウ蛋白 |
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| Research Abstract |
We observed the amyloid deposits in the peripheral nerves of the patient with familial amyloid polyneuropathy (FAP) by electron microscopy and obtained the three dimensional structure of them. Amyloid fibrils deposited in FAP is constructed of tubular structure which is made with piled up circles containing 5 or 6 subunits. This structure is different from it of amyloid fibrils deposited in the senile plaques in the brains of Alzheimer's disease. It might be suggested that difference of ultrastructure of amyloid fibrils in these two diseases determines the organs in which amyloid deposits.
Abnormal tau protein which has been reported to exists only in the neurofibrillary tangles (NFTs) was demonstrated in the granulo-vacuolar degeneration in hippocampal neurons. This finding is the evidence of the intracellular digestion of NFTs. It is very important to clarify the digestive pathway of in the neuronal cells.
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