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A study on the pathophysiology of diffuse Lewy body disease

Research Project

Project/Area Number 07457212
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionYokohama City University

Principal Investigator

KOSAKA Kenji  Yokohama City University Department of Psychiatry, Professor, 医学部, 教授 (60023800)

Co-Investigator(Kenkyū-buntansha) GOTOU Kenichi  Yokohama City University Department of Psychiatry, Assistant, 医学部, 助手 (00254201)
小田原 俊成  横浜市立大学, 医学部, 助手 (00244426)
ONISHI Hideki  Yokohama City University Department of Psychiatry, Lecturer, 医学部, 講師 (30275028)
ISEKI Eizo  Yokohama City University Department of Psychiatry, Assistant professor, 医学部, 助教授 (30203061)
山田 芳輝  横浜市立大学, 医学部, 講師 (70220415)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1997: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1995: ¥2,200,000 (Direct Cost: ¥2,200,000)
KeywordsDiffuse Lewy body disease / Dementia with Lewy bodies / Lewy bodies / Ubiquitin-positive neurites / Apolipoprotein E / Amygdala / ユビキチン陽性変性神経突起 / ユビキチン陽性顆粒 / 海面状態 / ユビキチン陽性構造物 / タウン陽性ミクログリア / 老人斑
Research Abstract

The results of our 3-year research on diffuse Lewy body disease (DLBD) are as follows :
1.Our investigation of 100 autopsied demented cases revealed that DLBD was the third frequent (15.4%) dementing illness, following Alzheimer-type dementia (43.6%) and vasculor dementia (23.1%).
2.Our immuno-electron microscopic examination disclosed that both spongy state in the entorhinal cortex and ubiquitin-positive neurites in the CA_<2-3> area, which are specific to DLBD,derive from degeneration of presynaptic terminals of large pyramidal neurons in the entorhinal cortex. It suggests that both the changes are closely related through the perforant pathway, and that they play an important role in memory disturbance of DLBD.
3.Ubiquitin-positive neurites were found not only in the hippocampal CA_<2-3> areas, but also in the parahippocampal cortex, amygdala (especially, central nucleus) and nucleus basalis of Meynert.
4.In the amygdala Lewy bodies were most frequently fpound in the medial parts of the accessory basal and basal nuclei.
5.A new cerebral type of Lewy body disease was found, in which numerous Lewy bodies were present in the cerebral cortex, but only rare in the brain stem nuclei.
6.The frequency of apolipoprotein E_4 was as high in the common form as in Alzheimer-typr dementia, but low in the pure form of DLBD.
7.The possibility of selective decrease of acetylcholine M_2 receptor in DLBD was suggested.
The second International Workshop on DLBD will be held in Amsterdam in July 1988. Then, Kosaka will give an invited lecture on DLBD research in Japan.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] Iseki E, et al.: "A pathological study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease." Neuropathology. 15. 112-116 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Odawara T, et al.: "Investigation of tau-2positive microglia-like cells in the sabcortical nuclei of human neurodegenerative disorders." Neurosci Lett. 192. 145-148 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 小阪 憲司: "Diffuse Lewy body disease." 臨床医学. 21. 60-62 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 近藤 直樹 他: "びまん性レビー小体病の臨床病理学的検討." 臨床精神医学. 24. 43-50 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K, et al.: "Cerebral type of Lewy body disease" Neuropathology. 16. 32-35 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawanishi S, et al.: "Neuropathological evaluation and apoliporotein E gene polymorphism analysis in DLBD." J Neurol Sci. 136. 140-142 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K, et al.: "Dementia with Lewy bodies." Current Opinion in Neurology. 9. 271-275 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E, et al.: "Age-related ubiquitin-positive granalar structures in non-demented subjects and neurodegenerative disorders." J Neurol Sci. 142. 25-29 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mckeith I, et al.: "clinical and pothological diagnosis of dementia with Lewy bodies (DLB)." Neurology. 47. 1113-1124 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 小阪 憲司: "びまん性レビー小体病の症例" 治療学. 30. 1057-1059 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E, et al: "Close relationship between spongiform change and ubiquitin-positive granular structures in diffuse Lewy body disease." J Neurol Sci. 146. 53-57 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E, et al.: "Hippocampal pathology in diffuse Lewy body disease using ubiquitin immunohistochemistry." J Neurol Sci. 149. 165-169 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 小阪 憲司: "びまん性レビー小体病" 臨床と研究. 74. 2483-2486 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 小阪 憲司: "びまん性レビー小体病" Clin Neurosci. 15. 1196-1197 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K.: "Diffuse Lewy body disease." Internal Medicine. 37. 6-10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K, et al.: "Diffuse Lewy body disease. In Practical Neurology of the Elderly." Marcel Dekkerp., 697-717 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K, et al.: "Diffuse Lewy body disease within the spectrum of Lewy body disease. In : Demeutia with Lewy Bodies-Clinical,Pathological and Treatment." Cambridge University Press., 238-247 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K, et al.: "Diffuse Lewy body disease and diffuse neurofibrillary tangles with calcification. In : Alzheimer's Disease : Biology,Diagnosis and Therapeutics." John Wiley & Sons Ltd., 179-183 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 小阪 憲司: "Lewy小体病.「臨床精神医学講座10器質・症状性精神障害」" 中山書店, 147-159 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E,Odawara T,Suzuki K,Kosaka K: "A pathlogical study of Lewy bodies and senile changes in the amygdala in diffuse Lewy body disease." Neuropathology. 15. 112-116 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Odawara T,Iseki E,Kosaka K,et al: "Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders." Neurosci Lett. 192. 145-148 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K: "Diffuse Lewy bodies." Clin Med. 21. 60-62 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kondoh N,Kosaka K,et al: "A clinicopathological study of diffuse Lewy body disease." Clin Psychiatry. 24. 43-50 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K,Iseki E,Odawara T,Yamamoto T: "Cerebral type of Lewy body disease." Neuropathology. 16. 32-35 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kawanishi S,Suzuki K,Iseki E,Kosaka K,et al: "Neuropathological evaluation and apolipoprotein E gene polymorphism analysis in DLBD." J Neurol Sci. 136. 140-142 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K,Iseki E: "Dementia with Lewy bodies." Current Opinion in Neurology. 9. 271-275 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E,Odawara T,Kosaka K,et al: "Age-related ubiquitin-positive granular structures in non-demented subjects and neurodegenerative disorders." J Neurol Sci. 142. 25-29 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mckeith I,Galasko D,Kosaka K,et al: "Clinical and pathological diagnosis of dementia with Lewy bodies (DLB)." Neurology. 47. 1113-1124 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K,Mark M,Sage JI: "Diffuse Lewy body disease." Practical Neurology of The Elderly. 697-717 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K,Iseki E: "Diffuse Lewy body disease within the spectrum of Lewy body disease." Dementia with Lewy Bodies. 238-247 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E,Li F,Kosaka K: "Close relationship between spongiform change and ubiquitin-positive granular structures in diffuse Lewy body disease." J Neurol Sci. 146. 53-57 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Iseki E,Li F,Odawara T,Kosaka K: "Hippocampal pathology in diffse Lewy body disease using ubiquitin immunohistochemistry." J Neurol Sci. 149. 165-169 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K: "Diffuse Lewy body disease." Psycho Topics. 106. 1-3 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K: "Diffuse Lewy body disease." Rinsho & Kenkyu. 74. 2483-2486 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K: "Recent topics of Lewy body." Clin Neurosci. 15. 1196-1197 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K,Iseki E: "Diffuse Lewy bodies disease and diffuse neurofibrillary tangle dementia. "Alzheimer's Disease :" Alzheimer's Disease. 179-183 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka K: "Diffuse Lewy body disease." Inter Med. 37. 6-10 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kosaka.K: "Diffuse.Lewy body disease" Internal Medicine. 37. 6-10 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iseki E,et al: "Close relationship between spongiform change and ubiquitin‐positive granular structures in diffuse Lewy body disease" J Neurol Sci. 146. 53-57 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iseki E,et al: "Hippocampal pathology in diffuse Lewy body disease using ubiquitin immunohistochemistry" J Neurol Sci. 149. 165-169 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小阪 憲司: "びまん性レビー小体病" Psycho Topics. 106. 1-3 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小阪 憲司: "びまん性レビー小体病" 臨床と研究. 74. 2483-2486 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小阪 憲司: "Lewy小体の最近の問題点" Clin Neurosci. 15. 1196-1197 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kosaka K,Iseki E: "Alzheimers Disease(Diffuse Lewy body disease)" John Wiley & Sons Ltd, 179-183 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小阪 憲司: "「器質・病状性精神障害」Lewy小体病" 中山書店, 147-159 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kosaka K.et al: "Cerebtal type of Lewy body disease" Neuropathology. 16. 32-35 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawanishi S,et al: "Neuropathological evaluation and apolipoprotein E gene polymorphism analysis in DLBD" J Neurol Sci. 136. 140-142 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kosaka K & Iseki E: "Dementia with Lewy bodies" Current Cpinion in Neurology. 9. 271-275 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iseki E,et al: "Age-related ubiquitin-positive granular structures in non-demented subjects and neuro degenerative disorders" J Neurol Sci. 142. 25-29 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mckeith.et al: "Clinical and pathological diagnosis of dementia with Lewy bodies (DLB)" Neurology. 47. 1113-1124 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 小阪憲司: "びまん性レビー小体病の症例" 治療学. 30. 1057-1059 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kosaka K,et al: "Dractical Neurology of the Elderly" Marcel Dekken, 697-717 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kosaka K,et al: "Dementia with Lewy Bodies-Clinical,Pathological and Treatment" Cambridge University Press, 238-247 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iseki E,et al.: "Apathological study of Lewy bodies and senile changes in the amygdala in DLBD." Neuropathology. 15. 112-116 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Odawara T,et al.: "Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders" Neurosci Lett. 192. 145-148 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 小阪憲司: "Diffuse Lewy body disease" 臨床医学. 21. 60-62 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 近藤直樹.他: "びまん性レビー小体病の臨床病理学的検討" 臨床精神医学. 24. 43-50 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kosaka K.: "Lewy Body Dementia“Pathology"" Cambride University Press, 296 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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