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Pressure contributes to mesangial injury associated with sytokines

Research Project

Project/Area Number 07457243
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionSaitama Medical School

Principal Investigator

SUZUKI Hiromichi  Saitama Medical School, Department of Nephrology, Professor, 医学部, 教授 (80129494)

Co-Investigator(Kenkyū-buntansha) NAKAMOTO Hidetomo  Saitama Medical School, Department of Nephrology, Associate, 医学部, 講師 (90180421)
岡宮 裕  慶應義塾大学, 医学部, 助手 (20245476)
中里 優一  慶應義塾大学, 保健管理センター, 講師 (20164155)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsPRESSURE / MESANGIAL CELLS / NEPHROSCLEROSIS / CYTOKINES / ADHESION MOLECULES / APOTOSIS / RENAL ARTERY / 培養細胞 / メサンジウム
Research Abstract

In clinical study, hypertension has a considerable effect on the renal sclerosis in patients with uninephrectomy more than 20 years ago. Using the isolated perfused hydronephrotic kidney models, nitric oxide modulates myogenic vasoconstriction of the afferent arteriole in spontaneously hypertensive rats, and chloride channels play an important role in afferent arterioleae constriction. In human mesangial cells, angiotensin II was expected to produce collagen synthesis under high pressure, however, no increases in collagen synthesis were found. By contrast, interleukin-4 modulates collagen synthesis. In addition, pressure induced apoptosis. Further, adhesion molecular contribute to apoptosis under high pressure. From these findings, it is suggested that pressure collaborates with cytokines but not angiotensin II and adhesion molecular may induce cytokine production.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Koichi Hayashi: "Nitric oxide modulates but does not impari myogenic vasoconstriciton of the afferent arteriole in spontaneously hypertensive rats" Hypertension. 25. 1212-1219 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akira Ohishi: "Status of patients who underwent uninephrectomy in adulthood more than 20 years ago" American Journal of Kidney Disease. 26. 889-897 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yuichi Nakazato: "Interleukin-4 modulates collagen synthesis by human mesangial cells in a type-specific manner" American Journal of Physiology. 270. F447-F457 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koki Arakawa: "Role of adenosine in the renal responses to contrast medium" Kidney International. 49. 1199-1206 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tsuneo Takenaka: "Role of chloride channels in afferent arteriolar constriction" Kidney International. 50. 864-872 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koichi Hayashi: "Nitric oxide modulates but does not impari myogenic vasoconstriciton of the afferent arteri ol in spontaneously hypertensive rats" Hypertension. 25. 1212-1219 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Akira Ohishi: "Status of patients who underwent uninephrectomy in adulthood more than 20 years ago" American Journal of Kidney Desease. 26. 889-897 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yuichi Nakazato: "Interleckin-4 modulates collagen synthesis by human mesangial cells in a type-specific manner" American Journal of Physiology. 270. F447-F457 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Koki Arakawa: "Role of adenosine in the renal responses to contrast medium" Kidney International. 49. 1199-1206 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tuneo Takenaka: "Role of chloride channels in afferent arteriolar constriction" Kidney International. 50. 864-872 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shibata,H.Suzuki,H.et al.: "Gene expression of angiotensin II receptor in blood cells of Cushing's syndrome" Hypertension. 26(part 1). 1003-1010 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Makazato,Y,Suzuki H et al.: "Interleukin-4 modulates collagen synthesis by human mesangial cells in a type-specific manner" American Journal of Physiology. 270. F447-F453 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takenaka,T.Suzuki H et al.: "Role of chloride channels in afferent arteriolar constrction" Kidney International. 50. 864-872 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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