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In situ solidifying liquids for medical application.

Research Project

Project/Area Number 07457251
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

IWATA Hiroo  Research Center for Biomedical Engineering Kyoto University, Associate Professor, 生体医療工学研究センター, 助教授 (30160120)

Co-Investigator(Kenkyū-buntansha) TAKI Waro  Graduate school of Medicine Kyoto University, Associate Professor, 医学研究科, 助教授 (70144368)
INOUE Kazutomo  Graduate school of Medicine Kyoto University, Associate Professor, 医学研究科, 助教授 (90168435)
IKADA Yoshito  Research Center for Biomedical Engineering Kyoto University, Professor, 生体医療工学研究センター, 教授 (00025909)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1997: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsAdhesion-pevention / aneurysm / Solidifying liquid / Tissue adhesive / cyanoacrylate / Poly (L-glutamic acid) / Gelatin / Thiol / 血管塞栓機 / 癒着防止機 / 細胞固定化機 / 細胞 / 血管内手術 / 組織工学 / 活性化エステル / ジスルフィド結合 / 水溶性高分子
Research Abstract

Liquid materials which can instantly form gels without damaging natural tissue will find many medical applications, such as treatment of arteriovenous malformation (AVM), stopping of bleeding and preparation of bioartificial organs. We prepared various liquid materials and examined their effctiveness using animal models.
Arteriovenous malformation : Embolic liquid was prepared by dissolving poly (2-hydroxyethyl methacrylate-co-methyl methacrylate) in Iopamiron with an addition of a small amount of ethyl alcohol. Isostearyl-2-cyanoacrylate was also synthesized for emboliation. These new embolic liquid is not cytotoxic and is easily injected into the AVM through a thin, long catheter to effectively occlude the AVM.
Hemostatic agent : The N-hydroxysuccinimide (NHS) activated poly (L-glutamic acid)(PLGA) was synthesized. This NHS activated PLGA could instantly form a gel with gelatin in an aqueous solution. This finding strongly suggest that this combination of gelatin and NHS-PLGA is verypromising as a hemostatic agent and adhesion-prevention agent, and may possibly replace fibrin glues prepared from human blood components.
Cell entrapment : The hydrogel was produced from a polyacrylamide derivative carrying thiol groups synthesized by redical copolymerization of acrylamide and N,N'-bis acrylcytamine, followed by reduction of the disulfide bonds in the copolymer. This water-soluble copolymer was used to entrap hamster islets by re-formation of disulfide bonds on the copolymer to produce a hydrogel. Insulin release from the islets in the hydrogel continued for more than 1 month when examined in vitro.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] H.Iwata et.al.: "Nontoxic embolic liquids for treatment of arteriovenous malformations." Journal of Biomedical Materials Research,Applied Biomaterials.28. 79-86 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Iwata et.al.: "Encapsulation of mammalian cells into synthetic polymer membranes using least toxic solvents." Joarnal of Biomater Scince, Polymer Edn.8. 575-586 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Iwata et.al.: "A novel surgical glue composed of gelatin and N-hydroxysuccinmide-activated poly (L-glutamic acid)" Biomaterials. in press. (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Iwata et.al.: "Entrapment of islets into soluble disufide hydrogels." Journal of Biomedical Materials Research. 40. 115-123 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Yamashita et.al.: "Acationic polymer,Eudragit-E as a new liquid embolic material for arteriovenous malformations." Neuroradiology. 38. S151-S156 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kiyoshi Kazekawa, Hiroo Iwata, Tetsuro Shimozuru, Kenji Sampei, Nobuyuki Sakaki, Noriyuki Morikawa, Shojiro Matsuda, Yoshito Ikada: "Nontoxic embolic liquids for treatment of arteriovenous malformations." Journal of Biomedical Materials Research, Applied Biomaterials. 28. 79-86 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Noriyuki Morikawa, Hiroo Iwata, Shojiro Matsuda, Jun-ichi Miyazaki and Yoshito Ikada: "Encapsulation of mammalian cells into synthetic poymer membranse using least toxic solvents." Journal of Biomater Scince, Polmer Edn.8. 575-586 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hiroo Iwata, Shojiro Matsuda, Kenji Mitsuhash, Eiji Itoh and Yoshito Ikada: "A novel surgical glue composed of gelatin and N-hydroxysuccinmide-activated poly (L-glutamic acid)" Biomaterials. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nobuharu Hisano, Noriyuki Morikawa, Hiroo Iwata, Yoshito Ikada: "Entrapment of islets into soluble disufide hydrogels." Journal of Biomedical Materials Research. 40. 115-123 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Yamashita, W.Taki, H.iwata, H.Kikuchi: "Acationic polymer, Eudragit-E as a new liquid embolic material for arteriovenous malformations." Neuroradiology. 38. S151-S156 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] H.Iwata et.al.: "Nontoxic embolic liquids for treatment of arteriovenous malformations." Journal of Biomedical Materials Research,Applied Biomaterials.28. 79-86 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Iwata et.al.: "Encapsulation of mammalian cells into synthetic polymer membranes using least toxic solvents." Joarnal of Biomater Scince,Polymer Edn.8. 575-586 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Iwata et.al.: "A novel surgical glue composed of gelatin and N-hydroxysuccinmide-activated poly (L-glutamic acid)" Biomaterials. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Iwata et.al.: "Entrapment of islets into soluble disufide hydrogels." Journal of Biomedical Materials Research. 40. 115-123 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Yamashita et.al.: "Acationic polymer,Eudragit-E as a new liquid embolic material for arteriovenous malformations." Neuroradiology. 38. S151-S156 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 岩田博夫: "Non-Toxic Embolic Liquids for Treatment of Arterioverous Malformation" J Applied Biomaterials. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩田博夫: "Encapsulation of Mammalian Cells into Synthetic Polymer Membranes using Least Toxic Solvents" Journal of BIOMATERIALS SCIENCE. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩田博夫: "生体組織工学" 産業図書, 241 (1995)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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