| Project/Area Number |
07457256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | NAGASAKI UNIVERSITY |
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Principal Investigator |
FUJIOKA Hikaru Nagasaki University, School of Medicine, Lecturer, 医学部, 講師 (00264226)
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| Co-Investigator(Kenkyū-buntansha) |
KANEMATSU Takashi Nagasaki University, School of Medicine, Professor, 医学部, 教授 (40128004)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1997: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1995: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | liver / transplantation / tolerance / immunogenicity / 肝移植 / トレランス / CD4 / CD8 |
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| Research Abstract |
In orthotopic liver transplantation from Lewis (LEW) into Wistar Furth (WF) rats, acute rejection response occurred transiently, followed by the spontaneous acceptance of the graft. In the previous study, we have found that primed cytotoxic T lymphocyte precursors (CTLp) were eliminated in long-term surviving recipient WF rats, and furthe rmore showed that LEW liver grafts from those animals had no allostimulatory activity. In this study, we investigated kinetic change in immunostimulatory activity of the graft and of the migrating donor cells from the graft into the recipient spleen. Allostimulatory activity of the liver graft was observed on days 1 and 2 and disappeared by day 3 after the trabsplantation. The spleen cells from recipient WF rats obtained 12 hours after liver transplantation showed potent allostimulatory capacity of LEW,but no such response was observed in vivo with the spleen cells obtained on day 3.
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