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New Risk Factors for Liver Metastasis of Colorectal Cancer

Research Project

Project/Area Number 07457267
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

ONO Masaya (1996)  The University of Tokyo, the 1st dept.of surgery, Instructor, 医学部・附属病院, 助手 (00270900)

澤田 俊夫 (1995)  東京大学, 医学部(病), 講師 (50143441)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Tadashi  The University of Tokyo, the 1st dept.of surgery, Instructor, 医学部・附属病院, 医員
SASAKI Shin  The University of Tokyo, the 1st dept.of surgery, Instructor, 医学部・附属病院, 医員
石丸 悟正  東京大学, 医学部(病), 助手 (70272557)
渡辺 聡明  東京大学, 医学部(病), 助手
尾野 雅哉  東京大学, 医学部(病), 助手 (00270900)
洲之内 広紀  東京大学, 医学部(病), 助手 (80221331)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1996: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsMMPs / MMP-1 / focal dedifferentiation / sLe (x) / cancer / metastasis / 肝転移 / リスクファクター
Research Abstract

The matrix metalloproteinase (MMPs) are a family of closely related enzymes that degrade the extracellular matrix proteins and are considered to be important in facilitating tumor invasion and metastasis. Using immunohistochemistry we investigated the expression of MMP-1 in colorectal carcinomas and its relationship with histopathological factors such as hematogenous metastasis, Dukes classification, lymphonode metastasis, depth of invasion, lumphatic invasion, and venous invasion. We found that the expression of MMP-1 in colorectal carcinoma correlates well with hematogenous metastasis and has a prognotic value independent of other histopathological factors.
We have also investigated the morphological features and the expression of sialyl-Lex in primary lesions of patients with colorectal carcinoma with liver metastasis. Both "focal dedifferentiation" and expression of sialyl Le^x antigen in the primary lesion were found to be good markers for assessing the metastatic proclivity of colorectal cancer.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Masaya Ono et al: "Cancer cell Morphology at the invasive Front and Expression of Cell Adhesion-Related Carbohydrate in the Primary Lesion of Patients with Liver Metastasis" Cancer Sep. 15. 1179-1186 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masaya Ono, et al.: "Cancer cell Morphology at the Invasive Front and Expression of Cell Adhesion-Related Carbohydrate in the Primary Lesion of Patients with Liver Metastasis" Cancer (Sep 15). vol.78/no.6. 1179-86 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 尾野 雅哉: "Cancer cell morphology at the invasive front and exprusion of cell adhsion-releted earbohybate in the primary lesion of patibets with cohretnlcorma with liver metetrion" Cancer. 78. 1179-86 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 尾野 雅哉: "早期の癌-病態から診断、治療まで-大腸" 臨床科学. 31(10). 1338-46 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 尾野 雅哉: "下血の緊急止血法" 外科治療. 74(5). 790-92 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 尾野 雅哉: "内視鏡手術、処置、大腸疾患" 外科診療. 38. 171-178 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 尾野 雅哉: "初療のためのフローチャート 直腸癌" 消化器外科. 19(6). 930-32 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 澤田俊夫: "各癌腫ごとの生存期間の変遷-直腸・結腸癌" PPACTICAL ONCOLOGY. 8. 13-15 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 澤田俊夫: "器械による低位前方切除・再建" 手術. 49. 1589-1597 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 澤田俊夫: "出血させない結腸・直腸癌手術(2)" 臨床外科. 50. 1177-1180 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 澤田俊夫: "腹会陰式直腸切断術" 消化器外科. 18. 994-1003 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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