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Development of Embolic materials and Catheter in Neurosurgical interventional radiologr

Research Project

Project/Area Number 07457313
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

TAKI Waro  Kyoto University, Neurosurgery, Associate Professor, 医学研究科, 助教授 (70144368)

Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsaneurysin / embolization / interventional radiology / arteriovenous malformation / 脳血管障害 / カテーテル / 接着剤 / 脳動脈瘤 / ステント
Research Abstract

The intravascular stent was examined for possible use for the cerebral aneurysmal treatment.
Methods) Two types of stent were made.1.polyurethane covered Strecker type stent, 2.Self cxpandable film stent.for the films.polethylene tereftarate (PET) film and poylypropylene (PP) film were made. Those stent were placed at the neck of the aneurysmal model and the clearance of the intrasaccular fluid was measured. The clearance curve was expressed by the equation of y=e. The clearance curve was different each other and the film stent showed the most slow clearance of the aneurysm.
The new liquid embolic material which is not adhesive was developed and evaluated. The new material was isostearylcyanoacrylate (ISCA). The new material and the n-butylcyanoacrylate (NBCA) was compared.
1) setting time of the materials was examined by dropping the liquid on to the water. The setting time was measured by videocamera. NBCA which is widely used as the liquid embolization material showed the setting time of 0.1 sec. In contrast ISCA showed the setting time of 10 second. By mixing NBCA and ISCA,the mixture showed thesame setting time of NBCA.By mixing the both material, appropriate setting time was obtained.
2) meaurement of adhesive force : NBCA showed the adhesive force of 135kgf, but ISCA showed minimum adhesive force too weak to measure.adhesive force was measured by gluing the catheter and the rabbit vessels.
3)viscocity : NBCA showed 3.162 cP and ISCA showed 7.420 cP.The latter is more viscus compared with NBCA.But by injecting this material through the maicrocatheter, the resistance was very low and it showed no disadvantage in the practical use.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] A.Sadato: "Immediatoly Detachable Coil for Aneurysm Treatment" AJNR. 16. 1459-1462 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Tanaka: "Changes in cerebral blood flow induced by balloon test occlusion of the internal carotid artery under hypotension" European Journal of Naclear Medicine. 22,11. 1268-1273 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] N.Nishi: "Embolization of Cerebral Aneurysms with a Liquid Embolus,EVAL Mixture : Report of Three Cases" Acta Neurochir (Wien). 138. 294-300 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Kondo: "Subacute macroscopic and histological change of an embolized arteriovenous malformation (AVM) with Eudragit-E" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 31-37 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Matsumoto: "Arteriovenous fistula closure with polymer coated stent in canine model" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 51-53 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Murao: "Clinical experiences of the immediately detachable coil" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 185-187 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.Nakahara: "Endovascular treatment of cavernous dural AVFs (spontaneous CCFs) : result of 50 patients" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 251-259 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Yamashita: "A cationic polymer,Eudragit-E, as a new liquid embolic material for arteriovenous malformations" Neuroradiology. 38.5. 151-156 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 中原 一郎: "頭蓋内硬膜動静脈瘻の治療" 脈管学. 8.1. 1-13 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 入江 恵子: "離脱型コイルを用いた内頸動脈眼動脈分岐部動脈瘤の血管内治療" 脳神経外科ジャーナル. 6.6. 363-368 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Irie: "Intra-aneurysmal Occlusion of Cerebral Aneurysms Using Detachable Coils Correlation of Aneurysm Neck Size and Treatment Results" Interventional Neuroradiology. 3.2. 114-117 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Irie: "Endovascular Treatment of a Partially Thrombosed Giant Basilar Tip Aneurysm Using Interlocking Detachable Coils-Case Report-" Neurologica modico-chirurgica. 37.9. 681-684 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Sadato: "Effect of electrical thrombosis on coil embolization of experimental aneurysms" J.Neurovascular Disease. 2.6. 235-245 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Sadato, W.Taki, Y.Ikada, I.Nakahara, K.Matsumoto, M.Tanaka, and H.Kikuchi: "Immediatoly Detachable Coil for Aneurysm Treatment" AJNR. 16. 1459-1462 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] F.Tanaka, S.Nishizawa, Y.Yonekura, N.Sadato, K.Ishizu, H.Okazawa, N.Tamaki, I.Nakahara, W.Taki, J.Konishi: "Changes in cerebral blood flow induced by balloon test occlusion of the internal carotid artery under hypotension" European Journal of Nuclear Medicine. 22,11. 1268-1273 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Nishi, W.Taki, I.Nakahara, A.Sadatoh, H.Kikuchi, H.Hondo, K.Matsumoto, H.Iwata, Y.Shimada: "Embolization of Cerebral Aneurysms with a Liquid Embolus, EVAL Mixture : Report of Three Cases" Acta Neurochir (Wien). 138. 294-300 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] S.Kondo, A.KOBAYASHI,H.Nagata, I.Nakahara, W.Taki, and K.Yamashita: "Subacute macroscopic and histological change of an embolized arteriovenous malformation (AVM) with Eudragit-E" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 31-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Koji Matsumoto, Waro Taki, Hiroo Iwata, Shojiro Matsuda, Haruhiko Kikuchi, and Yoshihiro Ikada: "Arteriovenous fistula closure with polymer coated stent in canine model" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 51-53 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kenichi Murao, Akiyo Sadato, Waro Taki, Yoshito Ikada, Ichiro Nakahara and Haruhiko Kikuchi: "Clinical experiences of the immediately detachable coil" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 185-187 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ichiro Nakahara, Waro Taki, Kenichi Murao, Naoki Ohkata, Koji Matsumoto, Fumiaki Isaka and H.Kikuchi: "Endovascular treatment of cavernous dural AVFs (spontaneous CCFs) : result of 50 patients" Advance in Interventional Neuroradiology and Intravascular Neurosurgery. 251-256 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Yamashita, W.Taki, H.Iwata, H.Kikuchi: "A cationic polymer, Eudragit-E,as a new liquid embolic material for arteriovenous malformations" Neuroradiology. 38. S151-156 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] I.Nakahara, W.Taki, N.Sakai, K.Irie, F.Isaka, H.Kikuchi: "Treatment of Intracranial Dural Arterioveous Fistulas" Jpn.J Phlebol.8(1). 1-3 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Irie, W.Taki, I.Nakahara, N.Sakai, F.Isaka, H.Kikuchi: "Endovascular Treatment for Internal Carotid-ophthalmic Aneurysms using Detachable Colis" Jpn.J Neurosurg. 6. 363-368 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Irie, W.Taki, I.Nakahara, N.Sakai, F.Isaka, H.Kikuchi, S.Nagao: "Intra-aneurysmal Occlusion of Cerebral Aneurysms Using Detachable Coils Correlation of Aneurysm Neck Size and Treatment Results" Interventional Neuroradiology. 3-2. 114-117 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Irie, W.Taki, I.Nakahara, N.Sakai, F.Isaka, and H.Kikuchi: "Endovascular Treatment of a Partially Thrombosed Giant Basilar Tip Aneurysm Using Interlocking Detachable Coils-Case Report" Neurologia medico-chirurgica. 37,9. 681-684 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] A.Sadato, W.Taki, Y.Ikada, H.Kikuchi: "Effect of electrical thrombosis on coil embolization of experimental aneurysms" J.Neurovascular Disease. vol.2.6. 235-245 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 滝 和郎: "脳動脈瘤の血管内治療-現況と将来" INNERVISON. 12,6. 23-26 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 坂井 信幸: "破裂脳動脈瘤の急性期治療-脳血管攣縮を含めて" INNERVISION. 12,6. 27-32 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 入江 恵子: "後頭窩動脈瘤の血管内治療" INNERVISION. 12,6. 33-38 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 中原 一郎: "巨大脳動脈瘤の血管内治療" INNERVISION. 12,6. 39-45 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 入江 恵子: "離脱型コイルを用いた内頸動脈眼動脈分岐部動脈瘤の 血管内治療" 脳神経外科ジャーナル. 6. 363-368 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiko Irie: "Intra-aneurysmal Occlusion of Cerebral Aneurysms Using Detachable Coils Correlation of Aneurysm Neck Size and Treatment Results" Interventional Neuraradiology. 3,2. 114-117 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Keiko Irie: "Endovascular Treatment of a Partially Thrombosed Giant Basilar Tip Aneurysm Using Interlocking Detachable Coils-Case Report-" Neurologica medico-chirurgica. 37,9. 681-684 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Akiyo Sadato: "Effect of electrical thrombosis on coil embolization of experimental aneurysms" J.Neurovascular Disease. 2,6. 235-245 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koji Matsumoto: "Arteriovenous fistula closure with polymer caated stent in canine model" Advances in Interventional Neurosurgery and Intravascular Neurosurgery. 51-53 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kenichi Murao: "Clinical experiences of the immediatly electrically detachable coil." Advances in Interventional Neurosurgery and Intravascular Neurosurgery. 185-187 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 中原一郎: "低血圧負荷およびCBF studyを併用した内頸動脈領域のBalloon Occlusion Test-半定量的評価による検討-、" 血管内手術における最近の進歩. 208-215 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 田中正人: "脳血管奇形の自然歴と破裂の予防" 循環科学. 15,5. 38-41 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 北条雅人: "PET activation studyによる言語機能のfunstional mappingが有用であった脳動脈奇形の1例" NEUROLOGICAL SURGERY. 23,6. 537-541 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akiyo Sadato: "Immediatoly Detachable Coil for Aneurysm Treatment" AJNR. 16. 1459-1462 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 村尾健一: "脊髄疾患の塞栓術" 中枢神経系におけるIVR. 10,2. 168-170 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 田中正人: "脳卒中の一次・二次予防 脳血管奇形の自然歴と破裂の予防" 循環科学.

    • Related Report
      1995 Annual Research Report
  • [Publications] I. Nakahara: "Dolichoectasia of the Middle Cerebarl Artery-Case Report-" Neurol Med Chir(Tokyo). 35. 822-824 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] F. Tanaka: "Changes in cerebral blood flow induced by balloon test occlusion of the internal carotid artery under hypotension" European Journak of Nuclear Medicine. 22,11. 1268-1273 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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