| Project/Area Number |
07457316
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Shimane Medical University |
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Principal Investigator |
YAMASAKI Toshiki Department of Neurosurgery, Shimane Medical University Associate Professor, 医学部, 助教授 (50201835)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Seiichi Department of Neurosurgery, Shimane Medical University Instructor, 助手 (80180454)
KAMEI Tsutomu Shimane Institute of Health Science, Division of Medical Research, Chief Researc, 研究部長
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1996: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | brain neoplasm / immunity / proto-oncogene / major histocompatibility complex antigen / natural killer cell / glioma / natural immunity / treatment / カルシウム / マクロファージ |
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| Research Abstract |
1. BASIC RESEARCH :
(1) Experimental analysis of relationship between proto-oncogene and histocompatibility complex antigen gene expressions during brain tumor progression.
(2) Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression.
(3) Role of nitric oxide and tumor necrosis factor-alpha produced by activated macrophages in cytotoxic activity on malignant glioma cells.
(4) Effects of nitric oxide and tumor necrosis factor-alpha on electrophysiological action in cultured neuronal cell line.
2. CLINICAL RESEARCH :
(1) Clinical significance of intraoperative monitoring method with endoscopy and Doppler ultrasound techniques for stereotactic surgery and microsurgery.
(2) Pharmacokinetic study on concentration of anti-cancer agents in intracranical tumor cavity after intravenous or intraarterial injection in patients with malignant brain tumors.
(3) Clinical significance of SPECT in differentiating diagnosis and evaluating predicting prognosis of a variety of brain neoplasms.
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