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GENE REGULATION UNDER THE HIGH INTRACRANIAL PRESSURE

Research Project

Project/Area Number 07457320
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNAGOYA CITY UNIVERSITY

Principal Investigator

YAMADA Kazuo  NAGOYA CITY UNIVERSITY,MEDICAL SCHOOL,PROFESSOR, 医学部, 教授 (90150341)

Co-Investigator(Kenkyū-buntansha) MASAGO Atsuo  NAGOYA CITY UNIVERSITY,MEDICAL SCHOOL,INSTRUCTOR, 医学部, 助手 (70209419)
MASE Mitsuhito  NAGOYA CITY UNIVERSITY,MEDICAL SCHOOL,INSTRUCTOR, 医学部, 助手 (60238920)
MATSUMOTO Takashi  NAGOYA CITY UNIVERSITY,MEDICAL SCHOOL,INSTRUCTOR, 医学部, 助手 (50199676)
KANAI Hideki  NAGOYA CITY UNIVERSITY,MEDICAL SCHOOL,ASSISTANT PROFESSOR, 医学部, 講師 (90185893)
KAMIYA Ken  NAGOYA CITY UNIVERSITY,MEDICAL SCHOOL,ASSOCIATE PROFESSOR, 医学部, 助教授 (70137115)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥6,700,000 (Direct Cost: ¥6,700,000)
Keywordsintracranial pressure / molecular biology / hydrocephalus / glutamate transporter / glial cell / stress response / subarachnoid hemorrhage / 浸透圧調節トランスポーター
Research Abstract

The present study was designed to investigate molecular biology of intracranial pressure (ICP) regulation. The investigators proposed research projects such as stress gene response, modification of glial function and osmoregulatory gene expression under the high ICP.The following results were obtained. (1) GLUTAMATE TRANSPORTER (GLAST) GENE EXPRESSION AND EXPERIMENTAL HYDROCEPHALUS : GLAST plays an important role in regulation of osmotic pressure and extracellular glutamate concentration. In the acute stage of experimental hydrocephalus, periventricular reactive astrocytes markedly expressed GLAST mRNA.High ICP and ventricular dilatation in the acute hydrocephalus cause periventricular edema and neuronal damage. GLAST gene might be induced in order to regulate local osmotic pressure or remove excess glutamate released from injured axons (Masago et al.1996). (2) ICP CHANGES AND STRESS GENE RESPONSE USING ICP CONTROLLABLE MODEL : We devised ICP controllable model in small animals (rats). … More The ICP levels were arbitarily regulated by the drip infusion system connected with cisterna magna. Under the high ICP level, the upregulation of hsp 70 mRNA and immediate early genes (IEGs) was demonstrated in the cerebral cortex, hippocampal formation and hypothalamic nucleus. Increased ICP could be physiological stress to many higher brain functions. Some of them might be acting to control ICP changes (Matsumoto et al.1995). (3) SUBARACHNOID HEMORRHAGE (SAH) MODEL AND NEURONAL STRESS : We developed orginal SAH model in rats by endovascular perforation with nylon thread. This model represents closely aneurysmal SAH.After SAH,hsp 70 mRNA and IEGs were induced in the cerebral cortex, thalamus and limbic system. Delayd neuronal loss in the hippocampal CA1 was observed. Not only ICP elevation but direct stimulation of subarachnoid blood might cause neuronal stress. (4) ONGOING PROJECT : Stress gene or apoptotic gene regulation after traumatic brain swelling using contusional model is under investigation. Less

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (83 results)

All Other

All Publications (83 results)

  • [Publications] 榊孝之、山田和雄: "神経細胞での低酸素耐性獲得気候の解析-ラット初代培養大脳皮質細胞でのin vitro実験-." Brain Hypoxia. 9. 13-17 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 松本勝美、山田和雄: "ラット中大脳動脈閉塞モデルに対するプロペントフィリン(HWA285)の保護効果の検討-線条体虚血に対する有効性について-." Brain Hypoxia. 9. 93-98 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山田和雄: "脳虚血におけるサイトカイン・神経栄養因子の役割." 脳卒中. 17. 517-521 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山田和雄: "虚血性脳血管障害の病態と治療." 現代医学. 42. 433-445 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 真砂敦夫: "水頭症性脳浮腫における上衣下細胞群のグルタメートトランスポーター(GLAST)遺伝子の発現." 第18回脳浮腫研究会報告集. 65-74 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 間瀬光人: "くも膜下出血後正常圧水頭症における髄液循環動態のMRIによる評価." Progress in Research on ICP. 65-71 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kohmura E,Yamada K: "Expression of c-fos mRNA after cortical ablation in rat brain is modulated by basic fibroblast growth factor(bFGF)and the NMPA receptor is involved in c-fos expression." Mol Brain Res. 28. 117-121 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yuguchi T,Yamada K: "Changes in growth inhibitory factor mRNA expression colpared with those in c-jun mRNA expression following facial nerve transaction." Mol Brain Res. 28. 181-185 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamashita N et al.: "Experience with a Programmable valve shunt system in pediatric hydrocephalus." Current Tr Hyd (Tokyo). 5. 38-42 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsumoto T et al.: "Changes of intracranial pressure (ICP) and gene expression using newly developed ICP controllable model in rats." Advances in Neurotrauma Research. 7. 23-28 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masago A et al.: "GLAST mRNA expression in the periventricular area of experimental hydrocephalus." NeuroReport. 7. 2565-2570 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Masago A et al.: "Changes of neuropsin mRNA expression in the hippocampus following rat focal brain ischemia." Restor Neurol and Neurosci. 10. 168-169 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fuse T et al.: "Heat shock-mediated cell cycle arrest is accompanied by induction of p21 CKI." Biochem Biophy Res Com. 225. 759-763 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Iwata A et al.: "Expression of basic fibroblast growth factor mRNA after transient focal ischemia : Comparison with expression of c-fos, c-fun and hsp70 mRNA." J Neurotrauma. 14. 197-206 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamada K et al.: Ischemic neuronal injury and gene expression of facilitative and inhibitory growth factor. In : Ito U,Kirino T,Kuroiwa T,Klatzo I (eds). Maturation phenomenon in cerebral ischemia II,Springer-Verlag, Berlin Heidelberg, 27-32 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 榊孝之、山田和雄: "神経細胞での低酸素耐性獲得機構の解析-ラット初代培養大脳皮質細胞でのin vitro実験-." Brain Hypoxia. 9. 13-17 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本勝美、山田和雄: "ラット中大脳動脈閉塞モデルに対するプロペントフィリン(HWA285)の保護効果の検討-線条体虚血に対する有効性について-." Brain Hypoxia. 9. 93-98 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "脳虚血におけるサイトカイン・神経栄養因子の役割." 脳卒中. 17. 517-521 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "虚血性脳血管障害の病態と治療." 現代医学. 42. 433-445 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 真砂敦夫: "水頭症性脳浮腫における上衣下細胞群のグルタメートトランスポーター(GLAST)遺伝子の発現." 第18回脳浮腫研究会報告集. 65-74 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 間瀬光人: "くも膜下出血後正常圧水頭症における髄液循環動態のMRIによる評価." Progress in Research on ICP. 65-71 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kohmura E, Yamada K: "Expression of c-fos mRNA after cortical ablation in rat brain is modulated by basic fibroblast growth factor (bFGF) and the NMDA receptor is involved in c-fos expression." Mol Brain Res. 28. 117-121 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yuguchi T, Yamada K: "Changes in growth inhibitory factor mRNA expression compared with those in c-jun mRNA expression following facial nerve transection." Mol Brain Res. 28. 181-185 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kubo T, Yamada K: "Assessment of auditory and vestibular functions after vestibular neurectomy for Meniere′s Disease." Acta Otoraryngol (Stockh). 115. 149-153 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yuguchi T, Yamada K: "Expression of growth inhibitory factor mRNA following cortical injury in rat." J Neurotrauma. 12. 299-306 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Anezaki T, Yamada K: "Expression of growth inhibitory factor (GIF) in normal and injured rat brains." Neurochem Int. 27. 89-94 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sakaki T, Yamada K: "Brief exposure to hypoxia induces bFGF mRNA and protein, and protects rat cortical neurons from prolonged hypoxic stress." J Cereb Blood Flow Metabol. 15Suppl. 68- (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuki H, Yamada K: "Time course of bFGF mRNA and protein induction following hypoxic neuronal injury and inhibition of bFGF protein synthesis in the peri-infarcted cortex." J Cereb Blood Flow Metabol. 15Suppl. 342- (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kohmura E, Yamada K: "Altered expression of growth in hibitory factor (GIF) messenger RNA after middle cerebral artery occlusion in rat." J Cereb Blood Flow Metabol. 15Suppl. 343- (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamashita T, Yamada K: "Changes in glutamate-aspartate transporter (GALST) mRNA expression following facial nerve transection." J Cereb Blood Flow Metabol. 15Suppl. 575- (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sakaki T, Yamada K: "Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress." Neurosci Res. 23. 289-296 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumoto T, Yamada K: "Changes of intracranial pressure (ICP) and gene expression using newly developed ICP controllable model in rats." Advances in Neurotrauma Research. 7. 23-28 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ito M, Yamada K: "Expression of PDGF in relation to cell division in artherosclerotic intima of human carotid arteries." Neurol Res. 17. 345-348 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本勝美,山田和雄:"脳虚血におけるアデノシンの役割と脳虚血治療への応用." 循環器科. 41. 16-22 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本 隆: "頭蓋内圧亢進のimmediate early gene (c-fos mRNA)発現に与える影響." サイメッド・パブリケーションズ.髄膜をめぐる諸問題.74-82 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 間瀬光人: "正常圧水頭症の髄液循環動態のMRIによる検討." サイメッド・パブリケーションズ.髄膜をめぐる諸問題.16-22 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Iwata A: "Expression of basic fibroblast growth factor mRNA after transient focal ischeuis ; Comparison with expression of c-fos c-jun and hcp 70 mRNA" J Neurotrauma. (in press).

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "成長因子と神経可塑性up-to-date." ブレインサイエンス. 7. 141-147 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "虚血と神経栄養因子." 脳と循環. 1. 260-265 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 松本 隆: "ラット頭蓋内圧亢進モデルにおけるc-fos, c-jun mRNA発現の変化." Progress in Research on ICP. 21-26 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 間瀬光人: "正常圧水頭症のMRIによる髄液循環動態の定量的評価." Progress in Research on ICP. 45-49 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 真砂敦夫: "ラット中大脳動脈閉塞モデルにおける海馬特異的セリンプロテアーゼ(neuropsin) mRNAの発現変化について." 神経化学. 35. 308-309 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 真砂敦夫: "ラット局所脳虚血モデルにおける海馬特異的神経プロテアーゼ(neuropsin) mRNAの発現の変化について." 神経組織の成長・再生・移植. 8. 9-10 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masago A: "GLAST mRNA expression in the periventricular area of experimental hydrocephalus." NeuroReport. 7. 2560-2570 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Masago A: "Changes of neuropsin mRNA expression in the hippocampus following rat focal brain ischemia." Restorative Neurology and Neuroscience. 10. 168-169 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsumoto K, Yamada K: "Amelioration of ischemic brain damage by the preischemic administration of propentofylline (HWA285) in a rat focal ischemia." Brain Res. 723. 228-230 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fuse T, Yamada K: "Heat shock-mediated cell cycle arrest is accompanied by induction of p21 CKI." Biochem Biophy Res Com. 225. 759-763 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "神経栄養因子の遺伝子発現と受容機構." 脳神経外科ジャーナル. 5. 118-127 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "脳虚血と神経栄養因子" 現代医療. 28. 1127-1232 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "佐藤 潔、福井仁士、山浦 晶(編集)脳神経外科レビュー3、" 三輪書店, 19 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山田和雄: "最新脳神経外科." 坪川孝志ら編.朝倉書店., 13 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kohmura E,Yamada K: "Expression of c-fos mRNA after cortical ablation in rat brain is modulated by basic fibroblast growth factor(bFGF)and the NMDA receptor is involved in c-fos expression." Mol Brain Res. 28. 117-121 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yuguchi T,Yamada K: "Changes in growth inhibitory factor mRNA expression compared with those in c-jun mRNA expression following facial nerve transection." Mol Brain Res. 28. 181-185 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kubo T,Yamada K: "Assessment of auditory and vestibular functions after vestibular neurectomy for Meniere′s Disease." Acta Otoraryngol(Stockh). 115. 149-153 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yuguchi T,Yamada K: "Expression of growth inhibitory factor mRNA following cortical injury in rat." J Neurotrauma. 12. 299-306 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Anezaki T,Yamada K: "Expression of growth inhibitory factor(GIF)in normal and injured rat brains." Neurochem Int. 27. 89-94 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sakaki T,Yamada K: "Brief exposure to hypoxia induces bFGF mRNA and protein,and protects rat cortical neurons from prolonged hypoxic stress." J Cereb Blood Flow Metabol 15[Suppl 1]. 68- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Otsuki H,Yamada K: "Time course of bFGF mRNA and protein induction following hypoxic neuronal injury and inhibition of bFGF protein synthesis in the peri-infarcted cortex." J Cereb Blood Flow Metabol 15[Suppl 1]. 342- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kohmura E,Yamada K: "Altered expression of growth inhibitory factor(GIF)messenger RNA after middle cerebral artery occlusion in rat." J Cereb Blood Flow Metabol 15[Suppl 1]. 343- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamashita T,Yamada K: "Changes in glutamate-aspartate transporter(GLAST)mRNA expression following facial nerve transection." J Cereb Blood Flow Metabol 15[Suppl 1]. 575- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sakaki T,Yamada K: "Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress." Neurosci Res. 23. 289-296 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mase M: "Endovascular stent placement for multiple aneurysm of the extracranial internal carotid artery:Technical case report." Neurosurgery. 37. 832-835 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamashita N,Kamiya K: "Experience with a programmable valve shunt system in pediatric hydrocephalus." Current Tr Hyd(Tokyo). 5. 38-42 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 布施 孝久、山田 和雄: "幼児期にSTA-MCA吻合術を行ったモヤモヤ病2症例の長期予後." 小児の脳神経. 20. 47-53 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 榊 孝之、山田 和雄: "神経細胞での低酸素耐性獲得機構の解析-ラット初代培養大脳皮質細胞でのin vitro実験-." Brain Hypoxia. 9. 13-17 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 早川 徹、山田 和雄: "神経内視鏡の臨床応用." Brain Update. 2. 8-9 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 木下 章、山田 和雄: "進行性脳底動脈塞栓症に対してtPA動注療法が有効であった1例." 救急医学. 19. 985-987 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松本 勝美、山田 和雄: "手術所見よりみた未破裂脳動脈瘤の破裂危険性および手術リスクの検討." The Mt.Fuji Workshop on CVD講演集. 13. 161-164 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 松本 勝美、山田 和雄: "ラット中大脳動脈閉塞モデルに対するプロペントフィリン(HWA285)の保護効果の検討-線条体虚血に対する有効性について-." Brain Hypoxia. 9. 93-98 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄、山田 謹子: "高次脳機能検査と脳循環代謝の評価法." Brain Nursing. 11. 855-861 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山下 伸子、神谷 健: "脳卒中を起こす脳血管の奇形." 循環科学. 10. 1014-1016 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大槻 秀夫、山田 和雄: "機能負荷SPECTとMRI重ね合わせによる大脳感覚運動野、視覚野の同定." CI研究. 17. 177-183 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 真砂 敦夫: "水頭症性脳浮腫における上衣下細胞群のグルタメートトランスポーター(GLAST)遺伝子の発現." 第18回脳浮腫研究会報告集. 65-74 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 間瀬 光人: "ステントを用いた多発性頭蓋外内頚動脈瘤の治療." 第10回日本脳神経血管内手術研究会講演集. 77-83 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 間瀬 光人: "くも膜下出血後正常圧水頭症における髄液循環動態のMRIによる評価." Progress in Research on ICP. 65-71 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 布施 孝久、山田 和雄: "可変式シャントシステム(SOPHY):バルブ前胸部設置における問題点." 脳外. 24. 41-45 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄: "国際学会見聞録、第17回国際脳循環代謝学会(Brain95 ケルン)" 脳と循環. 1. 94-97 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄: "神経栄養因子とその臨床的意義-特にFGFの虚血損傷修復に果たす役割について." PTM. 7. (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄: "山口 武典、早川 徹、高橋 睦正(編)中枢神経疾患の画像診断" 最新医学社, 7 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄: "佐藤 潔、福井 仁士、山浦 晶(編集)脳神経外科レビュー3" 三輪書店, 19 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄: "今日の治療指針1996年版" 医学書院, 1 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 山田 和雄: "山浦 晶(編)脳動脈瘤の外科" 医学書院, 6 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamada K: "in Hakuba A(ed)Surgery of the Intracranial Venous System" 7 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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