| Project/Area Number |
07457328
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | UNIVERSITY OF TOKYO |
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Principal Investigator |
IIJIMA Takuo Univ.of Tokyo, the Univ.of Tokyo Hosp., Assistant, 医学部・附属病院, 助手 (60176039)
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| Co-Investigator(Kenkyū-buntansha) |
GOTO Takahiro Univ.of Tokyo, the Univ.of Tokyo Hosp., Assistant, 医学部・附属病院, 助手 (20272544)
UMEYAMA Takasige Univ.of Tokyo, the Univ.of Tokyo Hosp., Assistant, 医学部・附属病院, 助手 (70160330)
ODA Hiromi Univ.of Tokyo, the Univ.of Tokyo Hosp., Lecture, 医学部・附属病院, 講師 (60101698)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥7,100,000 (Direct Cost: ¥7,100,000)
Fiscal Year 1996: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | musculoskeltal sarcoma / surgical margin / Erb B2 / resistance-related protein / ErbB-2 |
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| Research Abstract |
1. Expression of ErbB2 in the tumors of 26 patients with conventional osteosarcoma was evaluated. In 42% of the osteosarcomas, the tumor cells expressed ErbB2. Expression of ErbB2 was strongly correlated with early pulmonary metastasis and poor prognosis.
2. Expression of resistance-related proteins was evaluated in 60 osteosarcoma specimen. Inherent overexprssion of heat shock protein 27 is independently related to poor outcome in osteosarcoma patients. Overexpression of glutation-S-transferase pi, heat shock protein 27, and lung resistance related protein at surgery might be associated with failure of preoperative chemotherapy.
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