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PATHOGENESIS OF IDIOPATHIC SCOLIOSIS

Research Project

Project/Area Number 07457342
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNIHON UNIVERSITY

Principal Investigator

MACHIDA Masafumi  Dept.of Orthop., Nihon Univ., Assist.Prof, 医学部, 講師 (30150717)

Co-Investigator(Kenkyū-buntansha) IMAMURA Yasuhide  Dept.of Orthop., Nihon Univ., Assist.Prof, 医学部, 講師 (30246871)
OKUMURA Eijiro  Dept.of Orthop., Nihon Univ., Assist.Prof, 医学部, 講師
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1997: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywordsidiopathic scoliosis / pathogenesis / melatonin
Research Abstract

This study was undertaken to examine to possibilities that a defect of melatonin may exist in human idiopathic scoliosis. We measured melatonin levels during 24-hour period in 45 adolescents 10 to 17 years old, 30 patients with idiopathic scoliosis and 15 age matched normal controls. All idiopathic scoliosis ranged 25 to 75 degrees were operated and classified as stable or progressive prior to surgery. If a curve had progressed less than 10 degrees of progression in the preceding year, it was classified as stabel. If a curve had progressed more than 10 degrees in the preceding year, it was considered to be progressive. Blood samples were centrifuged and the plasma was kept frozen until analyzed. The levels of melatonin was measured with use of a radioimmunoassay. In all subjects the melatonin levels showed diurnal variations with low in the day and high at night. We found a highly significant decrease in the melatonin levels in patients with progressive scoliosis through the night when compared to the stable or control subjects. Melatonin levels were 1/3 or 35% less in the progressive scoliosis when compared to the stable scoliosis patients ; the levels in the stable group and the control were similar. Melatonin levels also appeared to be possible predictor of spine curve progression, i.e., the lower melatonin levels associated with the greater prognosis of curvature. However, there was no correlation between degree of curvature of the spine and the melatonin level. Our study suggests that normal melatonin synthesis or metabolism may be important for the symmetric development of the proprioceptive system and paraspinal muscles. Also the level of melatonin appears to be a useful prediction of progression of spine curvature in idiopathic scoliosis.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Machida M. et al.: "Role of melatonin deficiency in the development of scoliosis in pinealectomized chickens" J. Bone Joint Surg. 77(B). 134-138 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Machida M. et al: "Melatonin : A possible role in pathogenesis of adolescent idiopathic scoliosis" Spine. 21. 1147-1152 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Machida M. et al: "Role of serotonin for scoliotic deformity in pinelectomized chicken" Spine. 22. 1297-1301 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 町田 正文 他: "特発性側弯症の病因:暗室で飼育したニワトリの血清メラトニン量と側弯変形" 脊椎脊髄. 11. 135-138 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Machida M.et al.: "Role of melatonin deficiency in the development of scoliosis in pinealectomized chickens" J.Bone Joint Surg.77(B). 134-138 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Machida M.et al.: "Melatonin : A possible role in pathogenesis of adolescent idiopathic scoliosis" Spine. 21. 1147-1152 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Machida M.et al.: "Role of serotonin for scoliotic deformity in pinealectomized chicken" Spine. 22. 1297-1301 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masafumi MACHIDA: "Role of serotonin for scoliotic deformity in pinealectomized chicken" Spine. 22・15. 1297-1301 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masafumi MACHIDA: "Melatonin : A possible role in pathogenesis of addescent idiopathic scoliosis" Spine. 21・10. 1147-1152 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2018-07-06  

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