| Project/Area Number |
07457349
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Chiba University |
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Principal Investigator |
NISHINO Takashi Chiba University School of Medicine Professor, 医学部, 教授 (80009703)
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| Co-Investigator(Kenkyū-buntansha) |
ISONO Shiroh Chiba University School of Medicine Assistant, 医学部, 助手 (80212968)
SATO Jiro Chiba University School of Medicine Lecturer, 医学部, 講師 (90187203)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1996: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1995: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Airway defensive reflexes / Propofol / Fentanyl / Sevoflurane / 気道反射 / 気道粘膜 / 麻酔深度 |
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| Research Abstract |
The first purpose of this study is to elucidate patterns of airway defensive reflexes elicited by a constant stimulation of airway mucosa in humans and the second purpose is to see the importance of various factors influencing airway reflexes in modification of airway defensive reflex responses. In this study we established the methidoiogy of elicitation and eveluation of airway defensive reflexes in humans. We also investigated the effects of an intravenous anesthetic agent (propofol) and a narcotic (fentanyl) on airway defensive reflexes. In addition, the effects of smoking habit and the influence of a voltile agent (sevoflurane) on airway defensive reflexes were investigated. The results were summarized as follows :
1.Both laryngeal and tracheal stimulation caused protective responses, such as cough reflex, expiration reflex, and spasmodic panting whereas bronchial stimulation caused little or no such responses.
2.An increase in depth of anesthesia shortened the response duration but did not affect the nature of the elicited responses.
3.It was impossible to suppress the airway defensive reflexes by administration of propofol alone but an addition of a small amount of fentanyl effectively depressed the airway defensive reflexes.
4.Smoking habit augmented the airway reflex responses but this was evident only with mechanical stimulation of the airway mucosa.
5.Sevoflurane which possesses a very mild airway-irritation may elicit airway defensive responses through the stimulation of the nasal mucosa.
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