| Project/Area Number |
07457359
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
SUMIKAWA Koji Nagasaki University School of Medicine Professor, 医学部, 教授 (60028660)
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| Co-Investigator(Kenkyū-buntansha) |
HASUO Hiroshi Nagasaki University School of Medicine, Hospital, Assistant, 医学部・附属病院, 助手 (40271126)
FUJIE Toru Nagasaki University School of Medicine, Hospital, Assistant, 医学部・附属病院, 助手 (90190008)
高松 俊子 長崎大学, 医学部・附属病院, 助手 (90264241)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1997: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥5,800,000 (Direct Cost: ¥5,800,000)
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| Keywords | Chronically Instrumented Dog / Anesthetics / Potassium Channels / Hemodynamics / Coronary Hemodynamics / Sevoflurane / Isoflurane / カリウムチャネル開口薬 |
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| Research Abstract |
The present study was carried out to determine the hemodynamic interactions of KATP channel openers and anesthetics in chronically instrumented dogs.
Dogs were chronically instrumented to measure mean arterial pressure (MAP), heart rate (HR), left circumflex coronary blood flow (CBF), cardiac output (CO), and regional contractile function (%SS). Hemodynamics were measured continuously in the conscious state or during anesthesia.
The KATP channel openers, cromakalim, nicorandil and JTV-506, were shown to have selectively potent effect on coronary vasodilation. The effects of coronary vasodilation caused by isoflurane and sevoflurane were completely abolished by a KATP channel closer, glibenclamide, suggesting that the activity of KATP channels might contribute the mechanism underlying volatile anesthetics on vasodilation. Isoflurane enhances the vasodilating action of cromakalim on both systemic and coronary vasculature and attenuates the cromakalim-induced increases in CO and myocardial contractility. The results also suggest that when the pharmacology of KATP channel openers are studied in animals, the effect of anesthetics should be excluded. The experiment of arrhythmias indicated that Ito but not KATP channels might be involved in the mechanism in producing halothane-epinephrine arrhythmias.
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