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Ultra-small doses of nitric oxide inhalation and oxygenation augmentation in severe respiratory failure

Research Project

Project/Area Number 07457360
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKumamoto University

Principal Investigator

OKAMOTO Kazufumi  Kumamoto University Hospital, Associate Professor, 医学部・附属病院, 助教授 (60093994)

Co-Investigator(Kenkyū-buntansha) KIKUTA Koichi  Kumamoto University Hospital, Assistant, 医学部・附属病院, 助手 (80264307)
KUKITA Ichiro  Kumamoto University Hospital, Lecturer, 医学部・附属病院, 講師 (60253746)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1996: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1995: ¥3,900,000 (Direct Cost: ¥3,900,000)
KeywordsNitric oxide / Respiratory failure / Pulmonary hypertension
Research Abstract

In adults and children with acute respiratory distress syndrome, we found the followings : (1) ultra-small doses of inhaled nitric oxide (125-500 ppb) improved oxygenation, (2) an increase in oxygenation by inhaled nitric oxide correlated with the baseline PaO_2, (3) inhaled nitric oxide promoted carbon dioxide elimination, (4) optimal concentrations of inhaled nitric oxide were at or less than 2-4 ppm, and (5) the very small doses of inhaled nitric oxide produced a negligible amount of nitric dioxide and could be used for a few months without side effects. These findings established the safe measures of inhaled nitric oxide and showed the significance of the ultra-small doses of inhaled nitric oxide as a life-saving method for severe respiratory failure. In addition, we noticed that, to improve oxygenation by inhaled nitric oxide, nitric oxide must reach the alveoli and found that combined uses of inhaled nitric oxide and positive end-expiratory pressure along with inverse ratio ventilation improved oxygenation.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 岡元和文,他: "ARDSに対するNO吸入療法" 血管と内皮. 6・増刊. 40-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岡元和文,他: "呼吸不全に対するNO吸入療法" 集中治療. 8・6. 607-614 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shibata Y,Okamoto K,et al.: "The safety of nitric oxide inhalation using a conventional high frequency oscillatory ventilator" Acta Paediatrica Japonica. 39・(in press). (1977)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sato T,Okamoto K,et al.: "Nitrogen dioxide production in a mitric oxide inhalation system using Servo ventilator 900C." Acta Paediatrica Japonica. 39・(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岡元和文: "“NOのすべて"平田結喜緒編" 医歯薬出版, 263-267 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岡元和文: "“NOの基礎と臨床"室田誠逸編" メディカルビュー, 207-308 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okamoto K,et al: "In haled nitric oxide for ARDS.(In Japanses)" Ketsukan To Naihi. 6 (Suppl). 40-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Okamoto K,et al: "In haled nitric oxide for respiratory failure. (In Japanses)" Syuchyuchiryou. 8 (61). 607-614 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sibata Y,Okamoto K,et al: "The safety of nitric oxide inhalation using a conventional high frequency oscillatory ventilator. (In English)" Acta Paediatrica Japonica. 39 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sato T,Okamoto K,et al: "Nitric dioxide production in a nitric oxide inhalation system using Servo ventilator 900C.(In English)" Acta Paediatrica Japonica. 39 (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岡元和文,他: "ARDSに対するNO吸入療法" 血管と内皮. 6・増刊. 40-46 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岡元和文,他: "呼吸不全に対するNO吸入療法" 集中治療. 8・6. 607-614 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shibata Y,Okamoto K,et al.: "The safety of nitric oxide in halation using a conventional high frequency oscillatory ventilator" Acta Paediatrica Japonica. 39(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sato T,Okamoto K, et al: "Nitrogon dioxide production in a nitric oxide inhalation system using Serro ventilator 900C" Acta Paediatrica Japonica. 39(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岡元和文: "“NOのすべて"平田結喜緒編" 医歯薬出版, P263-267 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岡元和文: "“NOの基礎と臨床"室田誠逸編" メディカルビュー, P207-308 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shibata Y,Okamoto K,et al: "Nitrogen dioxide concentrations in a nitric oxide inhalation system using a conventional infant respilator" Acta Paediatrica Japonica. 38 in press. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡元 和文,久木田一朗,他: "呼吸不全に対するNO吸入療法" 集中治療. 8. in press (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kukita I,Okamoto,et al.: "Evaluation of Mapleson system for administration of inhaled NO." J Anesth. 10. 44-48 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡元和文: "ARDSに対するNO吸入療法とECLA" 医学のあゆみ. 172. 369-372 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡元和文: "NOと病態-最新情報-" 中外医学社, 263 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岡元和文: "NO研究の基礎と臨床" 医学図書出版, 62 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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