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Role of BMP in fracture repair

Research Project

Project/Area Number 07457432
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionShowa University

Principal Investigator

YAMAGUCHI Akira  School of Dentistry, Showa University, Associate Professor, 歯学部, 助教授 (00142430)

Co-Investigator(Kenkyū-buntansha) YOSHIKI Shusaku  School of Dentistry, Showa University, Professor, 歯学部, 教授 (30085740)
横瀬 敏志  昭和大学, 歯学部, 助手 (90245803)
池田 通  昭和大学, 歯学部, 講師 (00211029)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1996: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsregeneration / fracture repair / BMP / Hedgehog / osteoblusts / 骨折 / 骨形成
Research Abstract

1) We investigated the histological changes occurred during fracture repair of ribs in 6-week old mice. On day 3 after fracture, chondrocytes appeared at fracture sites. ALP-positive osteoblasts first appeared at the fracture sites on day 4 after fracture.
2) The expression of mRNAs of BMP-2, BMP-4 and Sonic hedgehog (Shh) were up-regulated on days 1 and 2 after fracture.
3) Shh induced osteoblastic differentiation in C3H10T1/2 and MC3T3-E1 cells.
4) The transplantation of the fibroblasts expressing Shh into muscular sites in nude mice induced ectopic bone formation.
These results demonstrated that BMPs and Shh play important roles during fracture repair.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Yamaguchi A,et al.: "Ettects of BMP-2-4 and-6 on osteoblastic differentiation of bone marrow derived stromal cell lines,ST2 and MC3T3-G2/PA6." Biochem.Biophys.Res.Commun.220. 366-371 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikeda T,et al.: "Cloning of rat type lreceptor mRNA for BMP-2 and BMP-4 and comparison of the ocalizalion of its ligand." Dev.Dynamics. 206. 318-329 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kinto.N.et al: "Fibroblast expressing Shh induces osteoblast differesdiddor" FEBS Letters. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Komori.T.,et al: "Target disruption of PEBP2αA gene results in complete lacks of bone formation" Cell. (印刷中). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi A,et al.: "Effects of BMP-2, -4 and -6 on osteoblastic differentiation of bone marrow derivedstromal cell lines, ST2 and MC3T3-G2/PA6." BBRC. 220. 366-371 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ikeda T,et al.: "Cloning of rat type I receptor mRNA for BMP-2 and BMP-4 and comparison of the mRNA localization of its ligand." Dev.Dynam.206. 318-329 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kinto N,et al.: "Fibroblasts expressing Shh induce osteoblast differentiation." FEBS Letters. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Komori T,et al.: "Targeted disruption of CBFA1/PEBP2alphaA gene results in complete lack of bone formation." Cell. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yokose S.et al.: "An estrogen deliciency caued by ocariectomy increases plasma levels of systemic factors that stimulate proloteration and differentiation of osteblasts in rats." Endocrinology. 137. 469-478 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kotake S,et al.: "Interleukin-6 and soluble interleukin 6 receptors found in synovial fluids are responsible for inducing joint disrruption in patients with rheumatoid arthritis." J.Bone Miner.Res.11. 88-95 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ida K,et al.: "A possible role of vitamin D receptors in regulating vitamin D activation in the kidney." Proc.Natl.Acad.Sci.USA. 92. 6112-6116 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yamaguchi A,et al.: "Effects of BMP-2,-4 and -6 on osteoblastic differentiation of bone marroe derived stromal cell lines,ST2 and MC3T3-G2/PA6." Biochem.Biophys.Res.Commun.220. 366-371 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikeda T,et al.: "Cloning of rat type lreceptor mRNA for BMP-2 and BMP-4 and comparison of the mRNA ocalization of its ligand." Dev.Dynamics. 206. 318-329 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikeda T,et al.: "Changes in biolgical activity of bone cells in ovarectomized rats revealed by situ hybridization." J.Bone.Miner.Res.11. 780-788 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yokose S, et al.: "An estrogen deficiency caused by ovariectomy increases plasma levels of systemic factors that stimulate proliferation and differentiation of osteoblasts in rats." Endocrinology. 137. 469-478 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kotake S, et al.: "Interleukin-6 and soluble interleukin 6 receptirs found in synovial fluids are responsible for inducing joint disruption in patients with rheumatoid arthritis." J. Bone Miner. Res.11. 88-95 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Iida K, et al.: "A possible role of vitamin D receptors in regulating vitamin D activation in the kidney." Proc. Natl. Acad. Sci. USA. 92. 6112-6116 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamaguchi A, et al.: "Effects of BMP-2, -4 and -6 on osteoblastic differentiation of bone marrow derived stromal cell lines, ST2 AND MC3T3-G2/PA6." Biochem. Biophys. Res. Commun. (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeda T, et al.: "Cloning of rat type lreceptor mRNA for BMP-2 and BMP-4 and comparison of the mRNA ocalization of its ligand." Dev. Dynamics (in press).

    • Related Report
      1995 Annual Research Report
  • [Publications] Ikeda T, et al.: "Changes in biological activity of bone cells in ovariectomized rats revealed by in situ hybridization." J. Bone Miner. Res. (in press).

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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