| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1996: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1995: ¥5,300,000 (Direct Cost: ¥5,300,000)
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| Research Abstract |
In human deciduous teeth, internal resorption of the coronal dentin takes place prior to shedding, and this resorption shows clear time-related histological changes. Furthermore, this phenomenon is closely associated with inflammatory reaction in the pulp. To determine possible factors involved in tooth resorption, in this study, immunohistochemical distribution of inflammatory cytokines such as IL-1, IL-6 and TNF in the various stage during the internal resorption of deciduous teeth. During the time the roots were actively being resorbed, no cytokines-positive cells could be found in the pulp. However, when the root resorption neared completion, cytokines-positive mononuclear cells started to gradually infiltrate into the pulp. After that, odontoclasts appeared in the pulp, and the resorption proceeded from the predentin to the dentin, and the number of cytokines-positive cells in the pulp gradually increased. At the end of the internal resorption, odontoclasts became detached from the resorbed dentin surface, and the dentinal resorption lacunae were filled by deposifion of cementum-like tissue. Throughout the process of this internal resorption and repair, cytokines-positive cells were always found in closely proximity to odontoclasts. The present study demonstrates in vivo that inflammatory cytokines may directly and/or indirectly participate in tooth resorption and repair.
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