| Project/Area Number |
07457506
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
矯正・小児・社会系歯学
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| Research Institution | Osaka University |
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Principal Investigator |
HANIOKA Takashi Osaka University, Faculty of Dentistry, Assistant Professor, 歯学部, 講師 (00144501)
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| Co-Investigator(Kenkyū-buntansha) |
KATAOKA Kosuke Osaka University, Faculty of Dentistry, Research Associate, 歯学部, 助手 (50283792)
TANAKA Muneo Osaka University, Faculty of Dentistry, Research Associate, 歯学部, 助手 (90263300)
SHIZUKUISHI Satoshi Osaka University, Faculty of Dentistry, Professor, 歯学部, 教授 (00028789)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1996: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Cigarette smoking / Blood flow / Oxygen tension / Nicotine / Gingival tissue / Periodontal pocket / Laser Doppler flowmeter |
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| Research Abstract |
Earlier studies on the effects of nicotine using a heat diffusion technique and a recent study on the effect of smoking using a laser Doppler flowmeter (LDF) demonstrated a decrease in gingival blood flow (GBF). Another studies on crevicular fluid flow and sulcus GBF indicated increased GBF after smoking. So far, results from the studies on acute effect of smoking on GBF are inconclusive. In this study, we measured GBF following smoking using LDF with different optic-fiber separations of 0.3 mm (LDF-0.3) and 0.7 (LDF-0.7). Prior to the study, we confirmed that the LDF-0.3 and difference between LDF-0.7 and LDF-0.3 (LDF-d) represented GBFs in superficial fraction and deeper fraction, respectively. Nine male smokers consuming 15-30 daily volunteered and were asked not to smoke at least 6 h before the experiment. The probe was fixed upon marginal gingiva of the second premolar in maxilla with a resin stent. After resting for 5 min, subjects sham smoked an unlighted cigarette for 5 min, then smoked the cigarette, and finally rested for 40 min. Systolic blood pressure and heart rate increased significantly after smoking (p<0.05). Changes in LDF-0.3 and LDF-d after smoking were not statistically significant. However, 6 subjects showed a decrease in LDF-0.3 immediately after smoking while smoking in 6 subjects caused a relative increase in LDF-d over sham smoking. Both the changes in the LDF readings after smoking were found in 4 subjects. These results in indicate that GBF tends to decrease in superfcial layr and increase in deeper layr after smoking.
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