| Project/Area Number |
07457532
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Josai University |
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Principal Investigator |
MARIMOTO Yasunori.Ph.D. University, Faculty of Pharmaceutical Sciences, Dean and Professor, 薬学部, 教授 (90001057)
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| Co-Investigator(Kenkyū-buntansha) |
NUMAJIRI Sachihiko.M.S. Josai University, Faculty of Pharmaceutical Sciences, Teaching Associate, 薬学部, 助手 (40245147)
木村 昌行 埼玉医科大学, 総合医療センター, 講師
SUGIBAYASHI Kenji.Ph.D. Josai University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (00105834)
KIMURA Masayuki.Ph.D. Saitama Medical Center, Saitama Medical School, Department of Pharmacy Services,
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1997: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | jet injector / iontophoresis / skin permeation / enhancing effect |
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| Research Abstract |
Although skin acts as a barrier to the penetration of ions or peptide-like drugs, high conductance pathways do appear to exist across membranes. Flow along these paths can be greatly enhanced by imposing a potential across the skin (iontophoresis). Furthermore, if the actual paths of ionic transport through the skin are enlarged by something, iontophoretic transport can be more greatly enhanced. The objective in this study is to evaluate the effectiveness of a new drug delivery system simultaneously using jet injection and iontophoresis. A jet injector was chosen to reduce transport barrier of skin.
At first, we checked the effect of jet injection on the drug permeation through the skin. After pretreatment of hairless rat skin by a jet injector containing physiological saline to make a pore in the skin, aqueous solution containing gentamycin sulfate and others was applied on the pore. Mathematical analysis showed that this larger pore greatly increased the skin delivery rate.^<1)>
At second, we checked the combined effects of jet injection and iontophoresis using sodium dichlofenac (DC-Na) and angiotensin II as model drugs. In the constant-current iontophoresis, the total amount of DC-Na permeated through the skin with jet injector was nearly equal to that without jet injector. No synergetic effect was observed in the constant-current iontophoresis with jet injector. When the jet injector was used, however, the resistance and potential difference across the skin were dramatically decreased as compared to that without jet injector. In the case of angiotensin II,the same phenomena was observed when using iontophoresis with jet injector. It is suggested from the results that the simultaneous use of iontophoresis with jet injector has no further penetration-enhancing effect under a constant-current, but an electric power-saving effect to transport a fixed amount of drug.
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