| Project/Area Number |
07457560
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | MEIJO UNIVERSITY |
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Principal Investigator |
KAMEYAMA Tsutomu MEIJO UNIVERSITY,PHARMACY,PROFESSOR, 薬学部, 教授 (10076698)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAMATSU Masayuki MEIJO UNIVERSITY,PHARMACY,ASSISTANT PROF., 薬学部, 助手 (10189863)
UKAI Makoto MEIJO UNIVERSITY,PHARMACY,ASSOCIATE PROF., 薬学部, 助教授 (80131209)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1996: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1995: ¥5,200,000 (Direct Cost: ¥5,200,000)
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| Keywords | DYNORPHIN / KAPPA-OPIOID RECEPTOR / CHOLINERGIC NEURONAL SYSTEM / IN VIVO MICRODIALYSIS / MEMORY AND LEARNING / PASSIVE AVOIDANCE TASK / CARBACHOL / HIPPOCAMUPUS / ガラニン / 一酸化炭素 / 自発的交替行動 |
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| Research Abstract |
The aim of the present study was to elucidate a physiological role for kappa-opioid receptor in the memory and learning process, using behavioral and neurochemical procedures. 1) Dynorphin A (1-13) injected into the lateral cerebroventnicle of mice prevented carbachol-induced impairment of memory. 2) U-50,488H,a selective kappa-agonist, improved scopolamine-or mecamylamine-induced impaiment of memory. 3) Perfusion of carbachol or mecamylamine by microdialysis in the rat's hippocampus decreased the extracellular acetylcholine concentrations there, and dynorphin A (1-13) inhibited ths change. nBNI,a selective kappa-antagonist, prevented the effect of dynorphin A (1-13). These results suggest an improving effect of kappa-opioid receptor agonists on impairment of memory and learning accompanied with a decrease in acetylcholine release in the hippocampus.
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