| Project/Area Number |
07457564
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOSHIMURA Manabu Kyoto Prefectural University of Medicine Faculty of Medicine, Professor, 医学部, 教授 (40094453)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1995: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Keywords | free dopamine / renal function / tubular dysfunction / alpha_1-microglobulin / beta_2-microglobulin / 尿中ドーパミン / 尿細管障害 / 臨床検査 / ファンコニ症候群 / 尿検査 / 糸球体障害 / 腎移植 / 腎臓 / クレアチニン / α_1-マイクログロブリン / β_2-マイクログロブリン / ROC解析 |
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| Research Abstract |
The free dopamine excreted in urine is derived from renal tubular dopamine, which is synthesized at the proximal tubules and regulates both natriuresis and diuresis. Urinary free dopamine derived from plasma dopamine is in negligible quantity. We investigated the usefulness of the urinary level of free dopamine as a marker of renal function, especially of tubular activity. We determined the correlations between the urinary level of free dopamine and a number of established markers of renal function. The urinary level of free dopamine was negatively correlated with the serum level of creatinine and the urinary levels of alpha_1-and beta_2-microglobulins. The receiver-operating characteristic (ROC) analysis indicated that urinary level of free dopamine is superior to other established renal parameters in sensitivity and specificity. In renal diseases, urinary level of free dopamine was significantly lower in patients with renal tubular dysfunction than in patients with glomerular dysfunction. Findings suggest that the urinary level of free dopamine is an index of renal function and is useful for evaluating renal impairments, especially renal tubular dysfunction.
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