| Project/Area Number |
07457594
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
BAMBA Tadao Shiga University of Medical Science, Department of Internal Medicine, Professor, 医学部, 教授 (40079819)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIKAWA Tomoyuki Shiga University of Medical Science, Department of Internal Medicine, Instructor, 医学部, 助手 (80273407)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
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| Keywords | ODC / colon cancer / mutation / antizyme |
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| Research Abstract |
Most of colon cancer tissue poses high ODC activity and putrescine content. We chose some of cancer tissues with extensively high ODC activity, extracted RNA and mede ODC cDNA by RT-PCR.Unfortunately, all of ODC cDNA which were sequenced did not has mutation. We speculate that much higher ODC activity of colon cancer was associated with the stability of ODC protein. We will investigate the relation antizyme mutation and ODC activity.
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