| Project/Area Number |
07457601
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
ENOMOTO Koji KEIO UNIVERSITY School of Medicine ASSOCIATE PROFESSOR, 医学部・外科, 助教授 (70051365)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yasuo KEIO UNIVERSITY School of Medicine ASSOCIATE, 医学部・外科, 助手 (20265846)
FURUKAWA Junji KEIO UNIVERSITY School of Medicine ASSOCIATE, 医学部・外科, 助手 (90265843)
TSUMANUMA Takashi FUJIKURA, 開発部, 課長(研究職)
米山 公康 慶應義塾大学, 医学部・外科, 助手 (30255484)
IKEDA Tadashi KEIO UNIVERSITY School of Medicine ASSISTANT PROFESSOR, 医学部・外科, 講師 (70124930)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1996: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | ENDOSCOPY / NIPPLE DISCHARGE / BREAST CANCER / SUPERFINESCOPE / Endoscopy / Nipple Discharge / Breast Cancer / Superfinscope / Superfinescope |
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| Research Abstract |
A histopathological examination demonstrated that twelve percent of patients with bloody nipple discharge had breast cancer. Accordingly, it is necessary to observe peridiocally an intraductal lesion in such patients for early detction of the breast cancer and a development of new instrument is desired for it's purpose.
AN SUPER FINESCOPE OF THE INTRADUCTAL LESION
We deviced an extrathine silica based image fiber in 1987 and we usedit clinically for detection of the intraductal lesion since 1991. Further, we deviced a semi-rigid type superfinescope with two channel which is used to inject the air in 1994. In addition to it, an improvement of the light source instrument and an enlargement of caliber of superfinescope with 3000 pixels made level up as high as ninety percent in success rate of the intrsductal lesions and at the same time we became to be able to observe it periodically and to compare it with an image on the other image diagnostic instrument.
AN IMPROVEMENT OF BIOPSY DEVICE WITH SUPERFINESCOPE
We made a new instrument (1.2mm in caliber) for biopsy and we tried to do biopsy an surgical specimen of the breast cancer. Although we could get tissue certainly, it was too thin to make a satisfactory section. It remains a necessity to improve an instrument.
INTRADUCTAL LASER TREATMENT
We are now assessing an efficacy and safety of the intraductal LASER treatment using Nd-YAG LASER and EXIMA dye LASER.We found that an optimal power was 18 watt in an uncontact continuous radiation on the surgical specimen of the breast cancer. However we used 10 watt clinically on the consideration of the safety. An alteration of the intraductal papillary lesion at the time of two weeks after LASER was observed and compared to histopathological findings. We are now trying to apply photodynamic therapy to treatment of the intraductal lesion.
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