| Project/Area Number |
07457612
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | TOKYO MEDICAL AND DENTAL UNIVERSITY |
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Principal Investigator |
ONO Toaki TOKYO MEDICAL AND DENTAL UNIVERSITY,THE SECOND DEPARTMENT OF ORAL AND MXILLOFACIAL SURGERY,FACULTY OF DENTISTRY,ASSOCIATE PROFESSOR, 歯学部, 助教授 (80014207)
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| Co-Investigator(Kenkyū-buntansha) |
ISHI Masatosi TOKYO MEDICAL AND DENTAL UNIVERSITY,THE SECOND DEPARTMENT OF ORAL AND MXILLOFACI, 歯学部, 講師 (70212826)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
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| Keywords | ARTIFICIAL MUCOUS MEMBRANE / COLLAGEN / WOUND DRESSINGS / WOUND CONTRACTION / EPITHELIZATION / 上皮細胞の三冷え細胞 / コラーゲンゲル収縮率 / 上皮細胞の3次元培養 / コラーゲンゲルの収縮率 |
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| Research Abstract |
1 : The present study was performed to macroscopically and histologically investigate wound healing responses in defects of the beagles palatal mucoperiosteum after implantations of TERUDERMIS and no implantations.
2 : The TERUDERMIS group exhibited better arrest of hemorrhage than the control group.
3 : The change of wound dimension (rate of wound contraction) of TERUDERMIS group was smaller than control group at any weeks.
4 : The TERUDERMIS group exhibited remarkably good growth of the epithelial regeneration of epithelial ridge.
5 : In connective tissue of the TERUDERMIS group, there were rich wide collagen fibers and so called 'pseudo-dermis were looked at 4 weeks. In control group, there were crudly thin collagen fibers and narbig connective tissue were looked.
6 : The process of absorption of the TERUDERMIS was also observed using immunostainning with antibovine serum monoclonal antibodies. The antibovine serum monoclonal antibodies was persistence at 2 weeks, but at 4 weeks that was not persistence. TERUDERMIS reconstructed completely the self connective tissue.
7 : The above results suggest the TERUDERMIS is available as an 'artificial mucous membrane' in defects of the mucoperiosteum.
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