| Project/Area Number |
07457616
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
AMINO Nobuyuki Osaka University Medical School Department of Laboratory Medicine Professor, 医学部, 教授 (60028694)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIWAI Taku Osaka University Medical School Department of Laboratory Medicine Assistant Prof, 医学部, 助手 (00252685)
TAKANO Toru Osaka University Medical School Department of Laboratory Medicine Assistant Prof, 医学部, 助手 (00263236)
TATSUMI Keita Osaka University Medical School Department of Laboratory Medicine Assistant Prof, 医学部, 助手 (00222109)
TADA Hisato Osaka University Medical School Department of Laboratory Medicine Lecturer, 医学部, 講師 (80263242)
HIDAKA Yoh Osaka University Medical School Department of Laboratory Medicine Associate Prof, 医学部, 助教授 (30243231)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Autoimmune disease / Graves'disease / Hashimoto's thyroiditis / Rheumatoid arthritis / Prediction of disease onset / Prevention of disease onset / Pregnancy and delivery / Hypothyroidism / 出産後発症 / 発病予防 / 慢性関節リュウマチ |
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| Research Abstract |
In order to predict postpartum onset of various autoimmune diseases, we measured autoantibodies in early pregnancy and followed antibody positive women after delivery and tried to prevent postpartum onset or aggravation of autoimmune diseases. Obtained conclusions are :
1) Measurement of serum antibodies in normal subjects could detect subclinical form of autoimmune diseases, at least thyroid disease and possibly rheumatoid arthritis.
2) Seven kinds of autoantibodies were measured and anti-thyroid microsomal antibody was found in 10.6% of women, suggesting that the high incidence of subclinical autoimmune diseases.
3) High tites (>20,000) of anti-thyroid microsomal antibody in early pregnancy was associated with postpartum onset of hypothyroidism, and destructive thyrotoxicosis was found before onset of hypothyroidism. Most hypothyroidism was transient but persistent one was found in one of 500 postpartum women.
4) Postpartum onset of Graves'disease could be predicted by measurement of microsomal antibody and then of thyroid stimulating antibody, and was found in one of 200 postpartum women.
5) For the prediction of postpartum onset of rheumatoid arthritis, measurement of rheumatoid factors were partly useful, but we need more specific antibodies to rheumatoid arthritis.
6) Small dose of steroid therapy started immediately after delivery for short duration was effective to prevent postpartum aggravation of autoimmune thyroid disease.
7) Postpartum onset of autoimmune disease was induced by immune rebound phenomenon after delivery.
Conclusion : Measurement of autoantibodies was useful to predict the onset of various autoimmune diseases after delivery and continuation of this study will enable to prevent postpartum onset of autoimmune disease.
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