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Axonal trajectory of inhibitory neurons in the piriform cortex

Research Project

Project/Area Number 07458202
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionTOHO UNIVERSITY

Principal Investigator

KISHI Kiyoshi  Toho Univ., Schl.of Med., 1st Dept.of Anat.Prof, 医学部, 教授 (00014118)

Co-Investigator(Kenkyū-buntansha) ODA Satoko  Toho Univ., Schl.of Med., 1st Dept of Anat.Assistant, 医学部, 助手 (90224237)
KAKUTA Sachiko  Toho Univ., Schl.of Med., 1St Dept.of Anat.Assist.Prof, 医学部, 講師 (80057752)
OJIMA Hisayuki  Toho Univ.Schl.of Med.1st Dept.of Anat.Assist.Prof, 医学部, 講師 (00104539)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1997: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1996: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1995: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordspiriform cortex / multipolar cell / axon collaterals / immunohistochemistry / GABA / pyramidal cell / guinea pig / 錐体細胞 / 神経細胞 / モルモット / 化学伝達物質
Research Abstract

Multipolar and pyramidal and neurons of layr III in the piriform cortex of guinra pig were studied by immunohistochmical and intracellular staining methods. Multipolar neurons show GABA-, calbindine-, and parvalbumin-like immunoreactivity. Intracellular staining study has revealed that size of soma of multipolar neuron is 19x17mum, and that some of dendrites reach to layrIa of the piriform cortex where they receive afferent input from the olfactory bulb.Total length of axon of single multipolar neuron is 90mm, and total number of nerve terminals (boutons) is 7000. Axon collaterals of single multipolar neurons make 5000 boutons (65% of total number of boutons) in layr III of piriform cortex, 1300 boutons (19%) in the zmygdaloid nucleus, 700 boutons (10%) in the insular cortex, 350 boutons (5%) in the dorsal endopiriform nucleus, and 80 boutons (1%) in the ventral pallidum.The collaterals might send feedback inhibition to pyramidal neurons in the piriform cortex as well as neurons in other area.
Pyramidal neurons show glutamate-like immunoreactivity and N-methyl-D-aspartate receptor 1 on their apical dendrites. Total length of axon of single pyramidal neuron is 140mm, and total number of nerve terminals (boutons) is 14000. Axon collaterals of single cell make 7000 boutons inlayr I to III of the piriform cortex, and send feedback excitation to pyramidal and multipolar neurons. The collaterals also reach to amygdaloid nucleus, entorhinal cortex, and insular cortex.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Ishikawa, Y., and Kishi, K.: "Frontier electronic study on odor molecules : Normal fatty acids and cyclamenaldehydes" International J.Quantum Chehmistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takei, H., Goto, Y., Ishikawa, Y., Kakuta, S., Chen, S.Y., Takayanagi, M., Kishi, K.: "Origin and migration of interneurous of the olfactory bulb in the musk shrew,Suncus murinus" Brain Behavior and Evolution. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kakuta, S., Oda, S., Takayanagi, M., Kishi, K.: "Parvalbumin immunoreactive neurons in the main olfactory bulb of the house musk shrew,Suncus murinus." Brain Behavior and Evolution. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ojima, H., Murakami, K., Kishi, K.: "Dual termination modes of corticothalamic fibers originating from pyramids of layer 5 and 6 in cat visual cortical area 17." Neuroscience Letters. 208. 57-60 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oda.S., Kuroda, M., Chen.S.Y., Shinkai, M., Kishi, K.: "Ultrasructure and distribution of axon termianls from the reticular thalamic nucleus to the anteroventral thalamic nucleus of the rat" J.Brain Res.37. 459-466 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ojima, H., Kuroda, M., Ohyama, J., Kishi k.: "Two classes of cortical neurons labelled with Vicia villosa lectin in the guinea-pig." Neuroreport. 6. 617-620 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishikawa, Y., and Kishi, K: "Frontier electronic study on odor molecules : Normal fatty acids and cyclamenaldehydes" International J.Quantum Chemistry. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takei, H., Goto., Y., Ishikawa, Y.Kakuta, S., Chen, S.Y., Takayanaki, M., Kishi, K.: "Origin and migration of interneurons of the olfactory bulb in the musk shrew, Suncus murinus" Brain Behavior and Evolution. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kakuta, S., Oda, S., Takayanagi, M,Kishi, K: "Parvalbumin immunoreactive neurons in the main olfactory bulb of the house musk shrew, Suncus murinus" Brain Behavior and Evolution. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ojima, H., Murakami, K., Kishi, K: "Dual temination modes of corticothalamic fibers originating from pyramids of layr 5 and Gin cat visual cortical area 17." Neuroscience Letters. 208. 57-60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Oda, S., Kuroda, M., Chen, S.Y., Shinkai, M., Kishi, K: "Ultrastrcture and distribution of axon terminals from the reticularthalamic nucleus to the anteroventral thalamic nucleus of the rat" J.Brain Res.37. 459-466 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ojima, H., Kuroda, M., Ohyama.J., Kishi.K: "Two classes of cortical neurons labelled with Vicia villosa lectin in the guinea-pig." Neuroreport. 6. 617-620 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ishikawa,Y., and Kishi,K.: "Frontier electronic study on odor molecules : Normal fatty acids and cyclamenaldehydes" International J.Quantum Chemistry. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Takei,H., Goto,Y., Ishikawa,Y., Kakuta,S., Chen,S.Y., Takayanagi,M., Kishi,K.: "Origin and migration of interneurons of the olfactory bulb in the musk shrew,Suncus murinus" Brain Behavior and Evolution. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Kakuta,S., Oda,S., Takayanagi,M., Kishi,K.: "Parvalbumin immunoreactive neurons in the main olfactory bulb of the house musk shrew, Suncus murinus." Brain Behaviour and Evolution. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Ojima,H., Murakami,K., Kishi,K.: "Dual termination modes of corticothalamic fibers originating from pyramids of layer 5 and Gin cat visual cortical area 17." Neuroscience Letters. 208. 57-60 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Oda,S., Kuroda,M., Chen,S.Y., Shinkai,M., Kishi,K.: "Ultrastructure and distribution of axon terminals from the reticular thalamic nucleus to the anteroventral thalamic nucleus of the rat" J.Brain Res.37・4. 459-466 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ojima,H., Kuroda,M., Ohyama,J., Kishi k.: "Two classes of cortical neurons labelled with Vicia villosa lectin inthe guinea-pig." Neuroreport. 6・47. 617-620 (1995)

    • Related Report
      1997 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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