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Intracellular responses by stimulation of receptors in neurons and related cells

Research Project

Project/Area Number 07458205
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKumamoto University

Principal Investigator

MIYAMOTO Eishichi  Kumamoto University School of Medicine, Pharmacology, Professor, 医学部, 教授 (50109659)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hideyuki  Kumamoto University School of Medicine, Pharmacology, Assistant Professor, 医学部, 講師 (60191433)
FUKUNAGA Kohji  Kumamoto University School of Medicine, Pharmacology, Associate Professor, 医学部, 助教授 (90136721)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 1996: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1995: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsReceptor / Intracellular response / Second messenger / Calcium ion / Enzyme activation / Cultured cell / Neuron / Glia / 初代培養細胞 / 細胞系 / 脳切片 / CaMキナーゼ / C / EBPファミリー / 転写因子 / 蛋白質燐酸化反応
Research Abstract

Neurons and related cells in the brain receive diverse stimuli for receptors in the plasma membranes, which include nerve impulses, neurotransmitters, neuropeptides, autacoids, hormones, cytokines, and growth factors. Responses of the cells include various types such as the production of second messengers and activation of tyrosine kinases. The intracellular calcium ion (Ca^<2+>) is established to be one of second messengers and its concentration in the cells is strictly regulated. The purposes of the present study are to elucidate the intracellular responses elicited by the increase in Ca^<2+> on the basis of stimulation of receptors in the plasma membranes. We used primarily cultured neurons of the hippocampus, astrocytes from cerebrum and cultured granule cells from cerebellum, established cell lines such as PC12 cells. NG108-15 cells, C6 glioma cells, fibroblast 3Yl cells and brain slices. In an attempt to elucidate the functions of the central nervous system through Ca^<2+> signaling pathways, we examined the dynamic state of activation of Ca^<2+>/calmodulin-dependent protein kinase II (CaM kinase II) in the cell systems. We found that CaM kinase II is activated through elevation of intracellular Ca^<2+> in response to the extracellular stimuli and is involved in the cellular functions of the central nervous system, such as neuronal differentiation of PC12 cells, gene expression in astrocytes and long-term potentiation in the CAl area of the hippocampus. Ca^<2+> is also involved in the activation of mitogenactivated protein kinase in neurons and astrocytes. Furthermore, with concomitant activation of the enzyme, phosphorylation of endogenous substrates was studied.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (80 results)

All Other

All Publications (80 results)

  • [Publications] F.Arakane: "Stimulation of cyclic adenosine 3',5'-monophosphate-dependent protein kinase with brain gangliosides" Neurochem.Int.26. 187-193 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Fukunaga: "Increased phosphorylation of Ca^<2+>/calmodulin-dependent protein kinase II and its endogenous substrates in the induction of long-term potentiation" J.Biol.Chem.270. 6119-6124 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Jaquet: "A site phosphorylated in bovine cardiac troponin T by cardiac CaM kinase II" Biochim.Biophys.Acta. 1248. 193-195 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ono: "Dephosphorylation of abnormal sites of tau factor by protein phosphatases and its implication for Alzheimer's Disease" Neurochem.Int.26. 205-215 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Morioka: "Glutamate-induced loss of Ca^<2+>/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons" J.Neurochem.64. 2132-2139 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Fujimoto: "Augmented expression of atrial myosin light chain 1 in ventricular aneurysms of human : Enzyme immunoassay for atrial myosin light chain 1" Biochem.Biophys.Res.Commun.207. 75-79 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] X.Sun: "Preparation of tau from the peripheral nerve : Presence of insoluble low molecular weight tau with high phosphorylation" Biochem.Biophys.Res.Commun.210. 338-344 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamamoto: "Phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) by proline-derected protein kinases and its dephosphorylation" J.Neurochem.65. 802-809 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Kuratsu: "Stimulatory effect of suramin on the proliferation of human glioma cells" Anticancer Research. 15. 1263-1268 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Kurino: "Activation of mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors" J.Neurochem.65. 1282-1289 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Matsumoto: "Ca^<2+>/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells" Endocrinology. 136. 3784-3793 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Hokimoto: "Increased angiotensin converting enzyme activity in left ventricular aneurysm of patients after myocardial infarction" Cardiovascular Research. 29. 664-669 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamamoto: "Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin" J.Biochem.118. 1224-1231 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.He: "Modification of neurofilament proteins by possible metabolites of allyl chloride in vitro" Drug and Chemical Toxicology. 18. 315-331 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Saito: "In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons" FEBS Lett.376. 238-242 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "シナプス機能は蛋白質燐酸化反応によってどのように調節されているのか" 生体の科学(特集「神経科学の謎」). 46. 32-36 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "LTPとCa^<2+>/カルモデュリン依存性プロテインキナーゼII" BRAIN MEDICAL (特集「分子神経生物学-最近の進歩」). 7. 51-56 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "シナプス伝達効率の調節と蛋白質燐酸化,脱燐酸化反応.「分子から高次脳機能へ 脳の階層性をふまえて」" 蛋白質核酸酵素・4月号増刊(編集・二木宏明,田中啓治,宮本英七,佐武明,中辻憲夫). 40. 682-690 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Tashima: "Overexpression of Ca^<2+>/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 Cells" J.Neurochem.66. 57-64 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura: "Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments" Dementia. 7. 177-181 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Tsutsui: "Ca^<2+>/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase" J.Neurochem.66. 2517-2522 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Yanagihara: "Phosphorylation of chromogranin A and catecholamine secretion stimulated by elevation of intracellular Ca^<2+> in cultured bovine adrenal medullary cells" J.Biol.Chem.271. 17463-17468 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Yano: "Regulation of CCAAT/enhancer binding protein (C/EBP) family members by stimulation of glutamate receptors in cultured rat cortical astrosytes" J.Biol.Chem.271. 23520-23527 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Ebihara: "Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells" Endocrinology. 137. 5255-5263 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Kurino: "Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes" J.Neurochem.67. 2246-2255 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Hokimoto: "Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction" Circulation. 94. 1513-1518 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto: "A role of Ca^<2+>/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area" Neurosci.Res.24. 117-122 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Fukunaga: "CaM kinase II in long-term potentiation" Neurochem.Int.28. 343-358 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "神経細胞由来の培養細胞を用いての脳賦活薬に関する細胞薬理学的研究" 臨床薬理の進歩'96. 56-64 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] D.Muller: "Mechanisms of Expression of long-term potentiation : Time-dependent reversal and role of protein kinases. In : Long-term Potentiation,Vol.2 (eds.M.Baudry and J.L.Davis)" The MIT Press (Cambridge), 16 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "蛋白キナーゼ.Atlas of Brain Mechanisms of Mind & Behavior.精神活動の流れを遡る-機能・構造・物質-(早石修・伊藤正男編)" メディカル・ジャーナル社(東京), 3 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "ニューロフィラメントタンパク質L,M,H(neurofilament proteins).廣川タンパク質化学9(脳・神経タンパク質,接着タンパク質I-2)(野村靖幸・編集)" 廣川書店(東京), 7 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 宮本英七: "シナプス伝達効率の調節と蛋白質燐酸化,脱燐酸化反応,分子から高次脳機能へ脳の階層性をふまえて.(二木宏明,田中啓治,宮本英七,佐武明,中辻憲夫・編集)" 共立出版社(東京), 9 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] F.Arakane, K.Fukunaga, M.Satake, K.Miyazaki, H.Okamura and E.Miyamoto: "Stimulation of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase with brain gangliosides." Neurochem.Int.26. 187-193 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Fukunaga, D.Muller and E.Miyamoto: "Increased phosphorylation of Ca^<2+>/calmodulin-dependent protein kinase II and its endogenous substrates in the induction of long-term potentiation." J.Biol.Chem.270. 6119-6124 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Jaquet, K.Fukunaga, E.Miyamoto and H.E.Meyer: "A site phosphorylated in bovine cardiac troponin T by cardiac CaM kinase II." Biochim.Biophys.Acta. 1248. 193-195 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Ono, H.Yamamoto, K.Tashima, H.Nakashima, E.Okumura, K.Yamada, S.Hisanaga, T.Kishimoto, T.Miyakawa and E.Miyamoto: "Dephosphorylation of abnormal sites of tau factor by protein phosphatases and its implication for Alzheimer's Disease." Neurochem.Int.26. 205-215 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Morioka, K.Fukunaga, S.Nagahiro, M.Kurino, Y.Ushio and E.Miyamoto: "Glutamate-induced loss of Ca^<2+>/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons." J.Neurochem.64. 2132-2139 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Fujimoto, H.Yasue, S.Hashida, K.Nakao, E.Ishikawa and E.Miyamoto: "Augmented expression of atrial myosin light chain 1 in ventricular aneurysms of human : Enzyme immunoassay for atrial myosin light chain 1." Biochem.Biophys.Res.Commun.207. 75-79 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] X.Sun, T.Tashiro, S.Hirai, H.Yamamoto, E.Miyamoto and Y.Komiya: "Preparation of tau from the peripheral nerve : Presence of insoluble low molecular weight tau with high phosphorylation." Biochem.Biophys.Res.Commun.210. 338-344 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamamoto, F.Arakane, T.Ono, K.Tashima, E.Okumura, K.Yamada, S.Hisanaga, K.Fukunaga, T.Kishimoto and E.Miyamoto: "Phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) by proline-directed protein kinases and its dephosphorylation." J.Neurochem.65. 802-809 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] J.Kuratsu, M.Kurino, K.Fukunaga, E.Miyamoto and Y.Ushio: "Stimulatory effect of suramin on the proliferation of human glioma cells." Anticancer Research. 15. 1263-1268 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Kurino, K.Fukunaga, Y.Ushio and E.Miyamoto: "Activation of mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamated receptors." J.Neurochem.65. 1282-1289 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Matsumoto, K.Fukunaga, J.Miyazaki, M.Shichiri and E.Miyamoto: "Ca^<2+>/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells." Endocrinology. 136. 3784-3793 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Hokimoto, H.Yasue, K.Fujimoto, R.Sakata and E.Miyamoto: "Increased angiotensin converting enzyme activity in left ventricular aneurysm of patients after myocardial infarction." Cardiovascular Research. 29. 664-669 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Yamamoto, M.Hasegawa, T.Ono, K.Tashima, Y.Ihara and E.Miyamoto: "Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin." J.Biochem.118. 1224-1231 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.He, M.Nagano, H.Yamamoto, E.Miyamoto and M.Futatsuka: "Modification of neurofilament proteins by possible metabolites of allyl chloride in vitro." Drug and Chemical Toxicology. 18. 315-331 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Saito, K.Ishiguro, T.Uchida, E.Miyamoto, T.Kishimoto and S.Hisanaga: "In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons." FEBS Lett.376. 238-242 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto: "How are synaptic functions regulated by protein phosphorylation? (in Japanese) (Special Issue "The mystery of Neuroscience")" Seitai no Kagaku. 46. 32-36 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto: "LTP and Ca^<2+>/calmodulin-dependent protein kinase II (in Japanese) (Special Issue "Molecular Neurobiology-Recent progresses")" Brain Medical. 7. 51-56 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto: "Regulation of synaptic transmission efficacy and protein phosphorylation and dephosphorylation (in Japanese) (April Sepcial Issue "From Molecule to Higher Functions of Brain on the Basis of Brain Hierarchy" [eds.H.Niki, K.Tanaka, E.Miyamoto, M.Satake and N.Nakatsuzi])" Tanpakushitsu Kakusan Kohso. 40. 682-690 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Tashima, H.Yamamoto, C.Setoyama, T.Ono and E.Miyamoto: "Overexpression of Ca^<2+>/calmodulin-dipendent protein kinase II inhibits neurite outgrowth of PC12 Cells." J.Neurochem.66. 57-64 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Kimura, T.Ono, J.Takamatsu, H.Yamamoto, K.Ikegami, A.Kondo, M.Hasegawa, Y.Ihara, E.Miyamoto and T.Miyakawa: "Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments." Dementia. 7. 177-181 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Tsutsui, N.Yanagihara, K.Fukunaga, K.Minami, Y.Nakashima, A.Kuroiwa, E.Miyamoto and F.Izumi: "Ca^<2+>/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase." J.Neurochem.66. 2517-2522 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] N.Yanagihara, Y.Oishi, H.Yamamoto, M.Tsutsui, J.Kondoh, T.Sugiura, E.Miyamoto and F.Izumi: "Phosphorylation of chromogranin A and catecholamine secretion stimulated by elevation of intracellular Ca^<+2> in cultured bovine adrenal medullary cells." J.Biol.Chem.271. 17463-17468 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Yano, K.Fukunaga, M.Takiguchi, Y.Ushio, M.Mori and E.Miyamoto: "Regulation of CCAAT/enhancer binding protein (C/EBP) family members by stimulation of glutamate receptors in cultured rat cortical astrosytes." J.Biol.Chem.271 (38). 23520-23527 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Ebihara, K.Fukunaga, K.Matsumoto, M.Shichiri and E.Miyamoto: "Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6 cells." Endocrinology. 137. 5255-5263 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] M.Kurino, K.Fukunaga, Y.Ushio and E.Miyamoto: "Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes." J.Neurochem.67. 2246-2255 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] S.Hokimoto, H.Yasue, K.Fujimoto, H.Yamamoto, K.Nakao, K.Kaikita, R.Sakata and E.Miyamoto: "Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction." Circulation. 94. 1513-1518 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto and K.Fukunaga: "A role of Ca^<2+>/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CAl area." Neurosci.Res.24. 117-122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Fukunaga, D.Muller and E.Miyamoto: "CaM kinase II in long-term potentiation." Neurochem.Int.28. 343-358 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto, K.Fukunaga, H.Yamamoto, T.Yamakawa, K.Tashima, T.Ono: "Cytopharmacological Study on Brain Stimulatory Drugs Using Neuron-Derived Cultured Cells (in Japanese)" Rinshoyakuri no Shinpo. '96. 56-64 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] D.Muller, K.Fukunaga and E.Miyamoto: Mechanisms of Expression of long-term potentiation : Time-dependent reversal and role of protein kinases, In : Long-term Potentiation, Vol.2, (eds.Michel Baudry and Joel L.Davis). The MIT Press, Cambridge, 65-80 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto: "Protein kinase. Atlas of Brain Mechanisms of Mind & Behavior" In : Going Upstream of Psychic Activity-Function. Structure. Substance (eds.O.Hayaishi and M.Ito) (in Japanese). Medical Journal (Tokyo), 131-133 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto, H.Yamamoto: "Neurofilament proteins L,M,H (Neurofilament Proteins)". In : Hirokawa Protein Chemistry (Brain. Nerve proteins, Adhesion Proteins I-2) (ed.Y.Nomura) (in Japanese). Hirokawa Shoten (Tokyo), 222-228 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] E.Miyamoto: "Regulation of Synaptic Transmission Efficacy and Protein Phospho-rylation and Dephosphorylation". In : From Molecule to Higher Functions of Brain on the Basis of Brain Hierarchy (eds.H.Niki, K.Tanaka, E.Miyamoto, M.Satake and N.Nakatsuzi) (in Japanese). Kyoritsu Shuppan (Tokyo), 106-114 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Tashima: "Overexpression of Ca^<2+>/Calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 Cells" J.Neurochem.66. 57-64 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] N.Yanagihara: "Phosphorylation of chromogranin A and catecholamine secretion stimulated by elevation of intracellular Ca^<2+> in cultured bovine adrenal medullary cells" J.Biol.Chem.271. 17463-17468 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] S.Yano: "Regulation of CCAAT/enhancer binding protein (C/EBP) family members by stimulation of glutamate receptors in cultured rat cortical astrosytes" J.Biol.Chem.271. 23520-23527 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Ebihara: "Cyclosporin A stimulation of glucose-induced insulin secretion in MIN6. cells" Endocrinology. 137. 5255-5263 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] M.Kurino: "Cyclic AMP inhibits activation of mitogen-activated protein kinase and cell proliferation in response to growth factors in cultured rat cortical astrocytes" J.Neurochem.67. 2246-2255 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] E.Miyamoto: "A role of Ca^<2+>/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CAl area" Neurosci. Res.24. 117-122 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 宮本英七: "シナプス伝達効率の調節と蛋白質燐酸化,脱燐酸化反応.分子から高次脳機能へ.脳の階層性をふまえて.(二木宏明,田中啓治,宮本英七,佐武明,中辻憲夫・編集)" 共立出版社, 9 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] K.Fukunaga: "Increased phosphorylation of Ca^<2+>/calmodulin-dependent protein kinase II and its endogenous substrates in the induction of long-term potentiation" J.Biol.Chem.270. 6119-6124 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Morioka: "Glutamate-induced loss of Ca^<2+>/calmodulin-dependent protein kinase II activity in cultured rat hippocampal neurons" J.Neurochem.64. 2132-2139 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Yamamoto: "Phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) by proline-directed protein kinases and its dephosphorylation" J.Neurochem.65. 802-809 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] M.Kurino: "Activation of mitogen-activated protein kinase in cultured rat hippocampal neurons by stimulation of glutamate receptors" J.Neurochem.65. 1282-1289 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Matsumoto: "Ca^<2+>/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells" Endocrinology. 136. 3784-3793 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] H.Yamamoto: "Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin" J.Biochem.118. 1224-1231 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 宮本英七: "蛋白キナーゼ.Atlas of Brain Mechanisms of Mind & Behavior.精神活動の流れを遡る-機能・構造・物質-(早石 修・伊藤正男編)" メディカル・ジャーナル社, 3 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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