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Elucidation of Adaptive Multimode Lubrication, Deterioration and Restoration in Natural Synovial Joints

Research Project

Project/Area Number 07458237
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MURAKAMI Teruo  Kyushu University, Faculty of Engineering, Department of Intelligent Machinery and Systems, Professor, 工学部, 教授 (90091347)

Co-Investigator(Kenkyū-buntansha) MOHTAI Masaaki  Kyushu University, Faculty of Medicine, Department of Orthopaedic Surgery, Resea, 医学部, 助手 (80202357)
MIURA Hiromasa  Kyushu University, Faculty of Medicine, Department of Orthopaedic Surgery, Lectu, 医学部, 講師 (10239189)
HIGAKI Hidehiko  Kyushu University, Faculty of Engineering, Department of Intelligent Machinery a, 工学部, 助手 (00238263)
OHTSUKI Nobuo  Kyushu Univer sity, Faculty of Engineering, Graphic Science, Associate Professor, 工学部, 助教授 (60127991)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsNatural Synovial Joints / Adaptive Multimode Lubrication / Synovia Constituents / Boundary Lubrication / Chondrocyte / Response of Cell to Mechanical Stimulation / Langmuir-Blodgett Method / Cytokine / Lungmuir-Blodgett法
Research Abstract

The object of this research is to elucidate the adaptive multimode lubrication mechanism in natural synovial joints and to clarify its relation to degradation and restoration.
The systematic investigation was performed to elucidate the adaptive multimode lubrication in natural synovial joints. Experimental evaluation of fluid film formation in knee joint model in simulator and numerical analysis showed the important role of elastohydrodynamic lubrication during walking. Impact tests of synovia and articular cartilage exhibited the existence of protecting film of proteins, particularly gamma-globulin after testing and impact-induced electrical phenomena of cartilage. In friction tests of pig shoulder joints by pendulum method, the influence of hyaluronate concentration on frictional behavior under high and low load conditions was clarified in related to effect of added proteins. The boundary lubrication by adsorbed film composed of phospholipids and proteins was clearly shown by an increase in friction after removal of adsorbed film. Addition of liposome of phospholipid and protein was effective in lowering of friction. Reciprocating tests of sliding pair of articular cartilage and Langmuir-Biodgett film formed on glass plate indicated the superiority of mixed film of phospholipid and protein to phospholipid film.
The continuous shearing to monolayr of cultured chondrocyte in cone/plate viscometer showed the remarkable increase in interleukin 6 (IL-6). This suggests that the shearing stimulation due to inferior lubrication plays an important role in deterioration and restoration in osteoarthritis.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 中西義孝: "ヒアルロン酸水溶液の潤滑性能に及ぼす電場の効果" 日本機械学会論文集(C編). 598・62. 2359-2366 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Murakami: "The Adaptive Multimode Lubrication in Biotribological Systems" Proc.of International Tribology Conference,Yokohama. 1981-1986 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Higaki: "The Boundary Lubricating Ability of Proteins in Natural Synovial Joints" Proc.International Tribology Conference,Yokohama. 1987-1992 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 日垣秀彦: "Langmuir-Blodgett法により作成した軟骨表面境界潤滑膜モデルの潤滑性能" 日本機械学会論文集(C編). 62・604. 4684-4689 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 日垣秀彦: "関節潤滑におけるジパルミトイルフォスファチジルコリンリポソームとγグロブリン投与による境界潤滑膜形成の効果" 日本機械学会論文集(C編). 63・606. 543-549 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 村上輝夫: "関節液系溶液の粘性挙動とその関節潤滑における役割" 日本機械学会論文集(C編). 63・607. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Y.Nakanishi: "Effects of Electric Field on Lubricating Ability of Sodium Hyaluronate Solution" Trans. Jpn. Soc. Mech. Engrs.62-598 C. 2359-2366 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Murakami: "The Adaptive Multimode Lubrication in Biotribological Systems" Proc. of International Tribology Conference, Yokohama. 1981-1986 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Higaki: "The Boundary Lubricating Ability of Proteins in Natural Synovial Joints" Proc. of International Tribology Conference, Yokohama. 1987-1992 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Higaki: "Lubricating Ability of Langmuir-Blodgett Films as Boundary Lubricating Films on Articular Surfaces" Trans. Jpn. Soc. Mech. Engrs.62-604 C. 4684-4689 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] H.Higaki: "Lubricating Effect of Boundary Films Forned by Addition of Liposomes of Dipalmitoyl Phosphatidylcholine and gamma-Globulin in Synovial Joints" Trans. Jpan. Soc. Mech. Engrs.63-606 C. 543-549 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] T.Murakami: "Viscous Property of Synovial Fluids and Related Solutions and Its Role in Joint Lubrication" Trans. Jpn. Soc. Mech. Engrs.63-607 C. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 中西義孝: "ヒアルロン酸水溶液の潤滑性能に及ぼす電場の効果" 日本機械学会論文集(C編). 598・62. 2359-2366 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] T.Murakami: "The Adaptive Multimode Lubrication in Biotribological Systems" Proc.of International Tribology Conference,Yokohama. 1981-1986 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] H.Higaki: "The Boundary Lubricating Ability of Proteins in Natural Synovial Joints" Proc.International Tribology Conference,Yokohama. 1987-1992 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 日垣秀彦: "Langmuir-Blodgett法により作成した軟骨表面境界潤滑膜モデルの潤滑性能" 日本機械学会論文集(C編). 62・604. 4684-4689 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 日垣秀彦: "関節潤滑におけるジパルミトイルフォスファチジルコリンリポソームとγグリブリン投与による境界潤滑膜形成の効果" 日本機械学会論文集(C編). 63・606. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 村上輝夫: "関節液系溶液の粘性挙動とその関節潤滑における役割" 日本機械学会論文集(C編). 63・607. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 日垣秀彦: "関節潤滑における関節液と軟骨表層の構成成分の役割 (第2報)蛋白成分の境界潤滑性" トライボロジスト. 40-7. 598-604 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 日垣秀彦: "生体関節における蛋白成分とリン脂質の境界潤滑作用" 日本機械学会論文集. 61-588. 3396-3401 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 日垣秀彦: "関節潤滑における蛋白成分の役割(第1報) -境界潤滑性の実験的評価-" 日本臨床バイオメカニクス学会論文集. 16. 403-407 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 中西義孝: "関節潤滑における蛋白成分の役割(第1報) -電場における摩擦制御-" 日本臨床バイオメカニクス学会論文集. 16. 369-374 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T. Murakami: "The adaptive multimode lublication in biotribological systems" Proc. Int. Tribology Conf. Yokohama. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] H. Higaki: "The boundary lubricating ability of proteins in natural synovial joints" Proc. Int. Tribology Conf. Yokohama. (in press). (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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