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Neuroendocrine and immune system in genetically polydipsic mice and development of animal model in response to environmental stress

Research Project

Project/Area Number 07507004
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionUniversity of Occupational and Environmental Health

Principal Investigator

YAMASHITA Hiroshi  University of Occupational and Environmental health, Department of Physiology, Professor, 医学部, 教授 (00030841)

Co-Investigator(Kenkyū-buntansha) INENAGA Kiyotoshi  Kyushu Dental College, Department of Physiology, Professor, 歯学部, 教授 (90131903)
YAMASHITA Uki  University of Occupational and Environmental Health, Department of Immunology, P, 医学部, 教授 (00028680)
KAWATA Mitsuhiro  Kyoto Prefectural University of Medicine, Department of Anatomy, Professor, 医学部, 教授 (60112512)
KANNAN Hiroshi  Miyazaki Medical College, Department of Physiology, Professor, 医学部, 教授 (00049058)
HORI Tetsuro  Kyushu University, Faculty of Medicine, Department of Physiology, Professor, 医学部, 教授 (00022814)
椛島 成利  産業医科大学, 医学部, 助手 (80279322)
上田 陽一  産業医科大学, 医学部, 講師 (10232745)
澁谷 泉  産業医科大学, 医学部, 助教授 (50162649)
大磯 ユタカ  名古屋大学, 医学部, 講師 (40203707)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥18,800,000 (Direct Cost: ¥18,800,000)
Fiscal Year 1997: ¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1996: ¥10,400,000 (Direct Cost: ¥10,400,000)
Keywordsgenetically polydipsic mice / salivary gland / laryngeal nerve / nociceptice response / thymus / glucocorticoid receptor / vasopressin / learning behavior / バゾプレシン / V2受容体遺伝子 / DNA合成能 / NK細胞活性 / オキシトシン / 抗利尿効果 / 上喉頭神経 / 遺伝性多飲(STR / N)マウス / c-fos mRNA / グルココルチコイド / バゾプレッシン遺伝子 / 脳スライス標本 / パッチクランプ法 / 細胞内Ca^<2+>濃度の画像解析
Research Abstract

The purpose of this study was to investigate the characteristics of genetically polydipsic mice from the higher function to genetics and the mechanisms of the neuroendocrine and immune responses to environmental stress in order to establish the animal model in response to the environmental stress. The polydipsic mice showed multiple abnormality as follows. 1. They may have abnormality of the muscarinic receptors in the saalivary glands and blood vessels. 2. The activity of the superior laryngeal nerve was lowar than control mice and large responses to high concentration of saline. 3. The thereshold of the nociceptive stress was lower tahn control mice and may be involved in the abnormality of mu-opiod receptor. 4. Although the number of thymic cells was increased, the differentiation of T cell was abnormal. 5. The glucocorticoid receptors expressed highly in the hypothalamic paraventricular nucleus, subfornical organ, amygdala and hippocampus. 6. The production of nitric oxide (NO) and NO synthase were increased in the paraventricular nucleus and decreased in the posterior pituitary. 7. The expression of vasopressin gene in the hypothalamus was increased after they became polydipsia. The genes of vasopressin and V2 receptor had no essential mutation. 8. Learning behavior showed abnormal in comparison with control mice. These results suggest that genetically polydipsic mice have multiple abnormality and useful animal model to investigate the responses to environmental stress.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (209 results)

All Other

All Publications (209 results)

  • [Publications] Shimizu, K., et al.: "Selective expression of HSP70-1 gene in the adrenal cortex but not in the medo of thermally stressed rats" Biochem.Biophys.Res.Commun.233. 550-554 (1997)

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  • [Publications] Inenaga, K., et al.: "Osmotic modullation in glutamatergic excitatory synaptic inputs toneurons in the supraoptic nudeus of rat hypothalamus in vitro" J.Neuroendocrinol.9. 63-68 (1997)

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  • [Publications] Shibuya, I., et al.: "Both GABA_A and GABA_B receptors participate in suppression of [Ca^<2+>]pulsing in toad melanotrophs" Eur.J.Pharmacol.321. 241-246 (1997)

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  • [Publications] Yamamoto, S., et al.: "Parathyroid hormone-related peptide-(1-34)[PTHrP-(1-34)induces vasopressin release from the rat supraoptic nucleus in vitro throuyh a novel neceptor distinct from a type I or type II PTH/P THrPreceptor" Endocrinology. 138. 2066-2072 (1997)

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  • [Publications] Hara, Y., et al.: "Increase of urocortin-like immunoreactivity in the hypothalamo-meurohypophysial system after salt loading and hypophysectoury" Neurosci.Lett.227. 127-130 (1997)

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  • [Publications] Yamamoto, S., et al.: "C-type natriuretic peptide suppresses arginine-vasopressin sccretion from dissociated magnocellular neurons in newborn rat supraoptic nucleus" Neurosci.Lett. 229. 97-100 (1997)

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  • [Publications] Tokunaga, M., et al.: "PTH-related peptide-like immunoreactivity in the median eminence,paraventricub and supraoptic nuclei in colhicine-treated rats" Brain Res.774. 216-220 (1997)

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  • [Publications] Uezono, Y., et al.: "Enhancement by baclofen of Gs-coupled receptor mediated cAMP production in Xenopus oocytes expressing rat brain cortex poly(A)^+ RNA:A cole of G-protein βγ subun." Biochem.Biophys.Res.Commun.241. 476-480 (1997)

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  • [Publications] Yamamoto, S., et al.: "Centrally administered parathyroid hormone(PTH)-related protein(1-34)but not PTH(1-34)stimulates arginine-vasopressin secretion and its messenger ribonudeic acid expression in supraoptic nucleus of the conscious rats" Endocrinology. 139. 383-388 (1998)

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  • [Publications] Shibuya, I., et al.: "PACAP increases the cytosolic Ca^<2+> concentration and stimulates somatodendritic vasopressin release in rat supraoptic neurons" J.Neuroendocrinol.10. 31-42 (1998)

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  • [Publications] Ueta, Y., et al.: "Neuronal nitric oxide synthase gene expression in human pituitury tumerg a possible association with somafotrogn adenomas and growth hormone-reteasug hormone gene expression" Clin.Endocrinol. (in press).

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  • [Publications] Tanaka, K., et al.: "PACAP causes Ca^<2+> release from ryanodine/caffeine stores througha novel pathway independent of both IP_3 and cAMP in bovine adrenal medullary cells" J.Neurochem.(in press).

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  • [Publications] Hara, Y., et al.: "Increase of urocootin-like immunoreactivity in the rat supraoptic nucleus after dehydration but not food deprivation" Neurosci,Lett.229. 65-68 (1997)

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  • [Publications] Anai, H., et al.: "Upregulation of the expression of vasopression gene in the paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat" Brain Res.772. 161-166 (1997)

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  • [Publications] Tanaka, K., et al.: "Pituitary adenylate cyclase-activating polypeptide potentiation of Ca^<2+> entry via protein kinase C and A pathways in melanotrophs of the pituitany pars intermed" Endocrinology. 138. 4086-4086 (1997)

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  • [Publications] Nomura, M., et al.: "Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ" Endocrinology. 138. 4096-4100 (1997)

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  • [Publications] Kabashima, N., et al.: "Inhibition of spontaneous EPSCs and IPSCs by presynaptic GABA_B receptors on rat supraoptic magnocellular neurons" J.Physiol.(Lond.). 504. 113-126 (1997)

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  • [Publications] Yamamoto, Y., et al.: "Upregulation of neuronal NOS in RNA in the PVN and SON of inherited diabetes insipidus rats" NeuroReport. 8. 3907-3911 (1997)

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  • [Publications] Ueta, Y., et al.: "Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventricular and supraoptic nuclei of rats" Brain Res.(in press).

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  • [Publications] Hattori, Y., et al.: "Ionotrophic and metabotropic glutamate receptor agonist-induced[Ca^<2+>]:increase in isolated rat supraoptic neurones" J.Neuroendocrinol.(in press).

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  • [Publications] Asada, N., et al.: "Identification of α and β cells in intact isolated islet of Laugerhans by their characteristic[Ca^<2+>]c dynamocs and immunocytochenical staining" Diabetes. (in press).

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  • [Publications] Uezono, Y., et al.: "Adrenomedulling increases intracellular Ca^<2+> and inositol 1,4,5-triphosphate in human oligodendroglial cell line KG-IC" Brain Res.(in press).

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  • [Publications] Uezono, Y., et al.: "Activation of inwardly rectifying K^+ by GABA-B receptors,expressed in Xenopus oocytes" NeuroReport. (in press).

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  • [Publications] Harayama, N., et al.: "Inhibition of N-and P/Q-type calcium channels by postsynaptic GABA_B receptor activation in rat supraoptic neurones" J.Physiol.(Lond). (in press).

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  • [Publications] Serino, R., et al.: "Upregulation of hypothalamic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats" Diabetologia. (in press).

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  • [Publications] Kannan, H.et al.: "Activation of sympathetic outflow by recombinant human interleukin-1β in conscious rats." Am.J.Physiol.270. R479-R485 (1996)

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  • [Publications] Tanaka, H.et al.: "Biphasic changes in behavioral,endocrine,and sympathetic systems in adjuvant arthritis in Lewis rats." Brain Res.Bull.39. 33-37 (1996)

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  • [Publications] Kannan, H.et al.: "Changes in renal sympathetic nerve activities in the regulation of body fluid balance with special reference to central neuropeptides in conscious rats." Jpn.J.Physiol.46. 111-122 (1996)

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  • [Publications] Hanamori, T.et al.: "Fiber types of the lingual branch of the trigeminal nerve, chorda tympani,lingual-tonsillar and pharyngeal branches of the glossopharyngeal nerve,and superior laryngeal nerve and their retation to the cardiovascular responses in rats." Neurosci.Lett.219. 49-52 (1996)

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  • [Publications] Ishizuka, Y.et al.: "Effects of area postrema lesion and abdominal vagotomy on interleukin-1β-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat." Neurosci.Lett.223(1). 57-60 (1996)

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  • [Publications] Kannan, H.et al.: "Effects of systemic interleukin-1β administration on daily drinking and renal excretory function in conscious rats." Physiol.Behav.61(5). 707-715 (1996)

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  • [Publications] 斉田 光彦et al.: "アドレノメデュリンと自律神経活動" 現代医療. 28. 2841-2844 (1996)

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  • [Publications] 花森 隆充et al.: "ラット島皮質ニューロンの咽頭・喉頭領域の味刺激に対する応答" 日本味と匂学会誌. 3. 480-483 (1996)

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  • [Publications] Yamashita, H.et al.: "Chemical control of vasopressin and oxytocin neurons in the supraoptic nucleus" Neurohypophysis:Recent progress of vasopressin and oxytocin research.197-204 (1995)

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  • [Publications] Ueta, Y.et al.: "Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat" Neuroscience Letters. 202. 37-40 (1996)

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  • [Publications] Tanaka, K.et al.: "PACAP causes rapid Ca^<2+> release from intracellular stores and long-lasting Ca^<2+> influx mediated by Na^+ influx-dependent membrane depolarization in bovine adrenal chromaffin cells." Endocrinology. 137(3). 956-966 (1996)

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  • [Publications] Inenaga, K.et al.: "GABAergic inhinbitory inputs to subfornical organ neurons in rat slice preparations" Brain Research. 105. 85-90 (1996)

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  • [Publications] Kawata, M.: "Roles of steroid hormones and their receptors in structural organization in the nervous system" Neurosicence Research. 24. 1-46 (1995)

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  • [Publications] Inenaga, K.et al.: "Osmotic modulation in glutamatergic excitatory synaptic inputs to neurons in the supraoptic nucleus of rat hypothalamus in vitro." J.Neuroendocrinol.63 (1997)

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  • [Publications] Myozaki, M. et al.: "Induction of autoimmune hepatitis and autoantibodies to liver antigens by neonatal thymectomy in mice" Clin.Exp.Imm unol.104. 133-143 (1996)

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  • [Publications] Fujii, S.et al.: "B cell mitogenic activity of house dust mite,Dermatophagoides farinae,antigens." Immunol.Letter. 49. 37-42 (1996)

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  • [Publications] Kishi, H.et al.: "Proliferation of retinal pigment epithelial cells by neuropeptides in vitro." Curr.Eye Res.15. 708-713 (1996)

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  • [Publications] Ueda, S.et al.: "Organization of regenerating serotonergic fibers in the hippocampal formation." Brain Res.Bull.39. 89-99 (1996)

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  • [Publications] Pasterkamp R.J.et al.: "The perinatal ontogeny of estrogen receptor-immunorectivity in the depeloping male and female rat hypothalamus." Dev.Brain Res.91. 300-303 (1996)

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  • [Publications] Hu, Z.et al.: "Exposure of postnatal rats to glucocorticoids suppresses the development of choline acetyltransferase-immunoreactive neurons:role of adrenal steroids in the development of forebrain cholinergic neurons." J.Chem.Neuroanat.10. 1-10 (1996)

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  • [Publications] Morimoto, M.et al.: "Phenotypic alterations of neuropeptide Y,vasoreactive interstinal peptide and cholone acetyltransferase in rat cultured cromaffin cells as effected by nerve growth factor and glucocorticoid." Arch.Histol.Cytol.59. 205-218 (1996)

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  • [Publications] Ueda, S.et al.: "Altertion of serotonergic innervation in the suprachiasmatic nucleus of the rat following removal of input fibers from retina and lateral geniculatenucleus." Neurosci.Lett.211. 97-100 (1996)

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  • [Publications] Yang, M.et al.: "The effects of nerve growth factor on newborn rat dosal root ganglion neurons in vitro" J.Brain Res.37. 313-317 (1996)

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  • [Publications] Bisser, D.T.M.et al.: "The alteration of glucocorticoid receptor-immunoreactivity in the rat forebrain following short-term and long-term adrenalectomy." Brain Res.729. 216-222 (1996)

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  • [Publications] Ueda, S.et al.: "Neuro-glial neurotrophic inteeraction in the S-100β retarded mutant mouse(Polydactyly Nagoya)." Brain Res.738. 15-23 (1996)

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  • [Publications] Morimoto, M.et al.: "Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain:an immunohistochemical and in situ hybridization study." Neurosci.Res.26. 235-269 (1996)

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  • [Publications] 堀 哲郎et al.: "発熱の病体生理" Today's Therapy. 20. 115-118 (1996)

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  • [Publications] 片淵 俊彦: "交感神経による脾臓ナチュラルキラー細胞活性制御の視床下部機序" 自律神経. 33. 267-272 (1996)

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  • [Publications] 岡 孝和: "痛みと情動" Clinical neuroscience. 14. 1025-1027 (1996)

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  • [Publications] Uchimura, D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide(PACAP)on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus(PVN)in vitro." J.Neuroendocrinol.8. 137-143 (1996)

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  • [Publications] Li, A-J.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

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  • [Publications] Shimizu, N.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

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  • [Publications] Mo, Z.L.: "The effects of IL-1β on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res.Bull.41. 249-255 (1996)

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  • [Publications] Oka, T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

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  • [Publications] Oka, T.: "Inhibition of peripheral interleukin-1-β-induced hyperalgesia by the intracerebroventricular administration of diclofenac and α-melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

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  • [Publications] Shibuya, I., et al.: "The Adrenal Chromaffin Cell" Hokkaido Llniv.Press, (1997)

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  • [Publications] Yamashita, H.: "The efhics of life" UNESCO, 238 (1997)

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  • [Publications] 山下 博 他: "循環器科" 科学評論社, (1997)

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  • [Publications] 渋谷 泉 他: "内分泌・糖尿病科" 科学評論社,

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  • [Publications] 上田 陽一, 他: "医学のあゆみ" 医歯薬出版, 102 (1998)

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  • [Publications] 河田 光博et al.: "現代の神経内分泌学" 下垂体後葉ホルモンの産生、分布、分泌機構, 179-186 (1196)

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  • [Publications] 堀 哲郎: "現代の神経内分泌学" メディカル・サイエンス・インターナショナル, 506 (1996)

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  • [Publications] 堀 哲郎: "最新内科学大系、Part 1.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)

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      「研究成果報告書概要(和文)」より
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      1997 Final Research Report Summary
  • [Publications] Hori, T.: "Discussion on Future Directions in Psychoneuroimmunology and Cancer." Nishimura Co.,Ltd.and Smith-Gordon Co.,Ltd., 166 (1996)

    • Description
      「研究成果報告書概要(和文)」より
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      1997 Final Research Report Summary
  • [Publications] Hori, T.: "Physiological Basis of Occupational Health:Stressful Environments." SPB Academic Publishing by, 278 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, H.et al.: "Biphasic changes in behavioral, endocrine and sympathetic systems in adjuvant arthritis in Lewis rats" Brain Res. Bull. 39 (1). 33-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, K.et al.: "Pituitary adenylate cyclase-activating polypeptide causes rapid Ca2_+ release from intracellular stores and long-lasting Ca2_+ influx mediated by Na2_+ influx-dependent membrane depolarization in bovin adrenal chromaffin cells." Endocrinology. 137 (3). 956-966 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Knnan, H.et al.: "Activation of sympathetic outflow by recombinant human interleukin-1b in conscious rats." Am. J.Physiol. 270. R479-R485 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Niwa, K.et al.: "Tempreture dependence of processes proximal and distal to the glucoseinduced [Ca2_+] i rise in stimulus-secretion coupling in rat pancreatic islets." Biol. Signals. 5. 30-43 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Tamura, M.et al.: "Enhanced glomerular profilin gene and protein expression in experimental mesangial proliferative glomerulonephritis." Biochem. Biophys. Res. Commun. 222. 683-687 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Nagatomo, T.et al.: "Proadrenomedullin N-terminal 20 peptide (PAMP) reduces inward currents and Ca2_+ rises indeuced by nicotine in bovine adrenal medullary cells." Life Sci.59 (20). 1723-1730 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Nomura, M.et al.: "PACAP type I receptor gene expression in the paraventricular and supraoptic nuclei of rats." NeuroReport. 8. 67-70 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Busik, J.et al.: "Effects of GABA on spontaneous [Ca2_+] c dynamics and electrical properties of rat adrenal chromaffin cells." Brain Res.739. 97-113 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Yoshihashi, K.et al.: "Contribution of Na_2/Ca2_+ exchange in maitaining [Ca2_+] c at a stable state in rat pancreatic islets." Jpn. J.Physiol.46. 473-480 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Osajima, A.et al.: "Adrenomedullin-sensitive receptors are prefentially expressed in cultured rat mesangial cells." Europian J.Pharmacol.315. 319-325 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Shimizu, K.et al.: "Selective expression of HSP70-1 gene in the adrenal cortex but not in the medulla of thermally stressed rats. Biochem." Biophys. Res. Commun.233 (2). 550-554 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Inenaga, K.et al.: "Osmotic modulation in glutamatergic excitatory synaptic inputs to neurons in the supraotic nucleus of rat hypothalamus in vitro." J.Neuroendocrinol.9. 63-68 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shibuya, I.et al.: "Both GABA_<1A> and GABA_<1B> receptors participate in suppression of [Ca2_+] i pulsing in road melanotrophs" Eur. J.Pharmacol.321. 241-246 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto, S.et al.: "Parathyroid hormone^related prptide-(1-34) [PTHrP-(a-34)] induced vasopressin release from the rat supraotic nucleus in vitro through a novel receptor distinct from a type I or type II PTH/PThrP receptor." Endocrinology. 138 (5). 2066-2072 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hara, Y.et al.: "Increase of urocortin-like immunoreactivity in the hypothalamoneurohypophysial system after salt loading and hypophysectomy." Neurosci. Lett. 227. 127-130 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Yamamoto, S.et al.: "C-type netriuretic peptide suppresses arginine-vasopressin secretion from dissociated magnocellular neurons in newborn rat supraoptic nucleus." Neurosci. Lett.229. 97-100 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hara, Y.et al.: "Increase of urocortin-like immunoreactivity in the rat supraoptic nucleus after dehydration but not food deprivation." Neurosci. Lett.229. 65-68 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Anai, H.et al.: "Upregulation of the expression of vasopressin gene in the paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat." Brain Res.772. 161-166 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, K.et al.: "Pituitary adenylate cyclase-activating polypeptide potentiation of Ca2_+ entry via protein kinase C and A pathways in melanotrophs of the pituitary pars intermedia of rats." Endocrinology. 138 (10). 4086-4095 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Nomura, M.et al.: "Water deprivation increases the expression of pituitary adenylate cyclase-activating polypeptide gene in the rat subfornical organ." Endocrinology. 138 (10). 4096-4100 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Kabashima, N.et al.: "Inhibition of spontaneous EPSCs and IPSCs by presynaptic GABAB receptors on rat supraotic magnocellular neurons" J.Physiol. (Lond.). 504 (1). 113-126 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Yamamoto, Y.et al.: "Upregulation of neuronal NOS mRNA in the PVN and SON of inherited diabetes insipidus rats." NeuroReport. 8 (18). 3907-3911 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Tokunaga, M.et al.: "PTH-related peptide-like immunoreactivity in the median eminence, paraventricular and supraoptic nucle in colhicine-treated rats." Brain Res.774. 216-220 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Uezano, Y.et al.: "Enhancement by baclofen of the Gs-coupled receptor-mediated cAMP production in Xenopus oocytes expressing rat brain cortex poly (A) + RNA : A role of G-protein bg subunits." Biochem. Biophys. Res. Commun.241. 476-480 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Osajima, A.et al.: "Adrenomedullin-sensitive receptors are preferetially expressed in cultured rat mesangial cells." Eur. J.Pharmacol.319-325 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yamamoto, S.et al.: "Centrally administrered parathyroid hormone (PTH)-related protein (1-34) but not PTH (1-34) stimulates arginine-vasopressin secretion and its messenger ribonucleic acid expression in supraopic nucloeus of teh conscious rats" Endocrinology. 139 (1). 383-388 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shibuya, I.et al.: "PACAP increases the cytosoric Ca2_+ concentration and stimulates somatodendritic vasopressin release in rat supraopic neurons." J.Neuroendocrinol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ueta, Y.et al.: "Neuronal nitric oxide synthase gene expression in human pituitary tumours : a possible association with somatotroph adenomas and growth hormone-releasing hormone gene expression." Clin. Endocrinol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Tanaka, K.et al.: "PACAP causes Ca2_+ release from rynaodine/caffeine stores through a novel pathway independent of both IP3 and cAMP in boving edrenal medullary cells." J.Neurochem.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ueta, Y.et al.: "Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventricular and supraoptic nuclei of rats." Brain Res.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Hattori, Y.et al.: "Ionotropic and metabotropic glutamate receptor agonist- induced [Ca2_+] i increase in isolated rat supraoptic neurones." J.Neuroendocrinol.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Asada, N.et al.: "Identification of a and b-cells in intact isolated islet of Langehans by their characteriscs [Ca2_+] c dynamics and immunocytochemical staning." diabetes. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Uezono, Y.et al.: "Adrenomedullin increases intracellular Ca2_+ and inositol 1,4,5-triphosphate in human oligodendroglial cell line KG-1C." Brain Res.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Uezono, Y.et al.: "Activation of inwardly recifying K_+ by GABA-B receptors expressed in Xenopus oocytes." NeuroReport. (in press).

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Harayama, N.et al.: "Inhibition of N- and P/Q-type calcium channels by postsynaptic GABAB receptor actication in rat supraoptic neurones." J.Physiol. (Lond.). (in press).

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Serino, R.et al.: "Upregulation of hypothalamic nitric oxide aynthase gene expression in steptozotocin-induced diabetic rats." Diabetologia. (in press).

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Ueta, Y.et al.: "Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of rat." Neurosci. Lett.202. 37-40 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Inenaga, K.et al.: "GABABergic inhibitory inputs to subfornical organ neurons in rat slice preparations." Brain Res.705. 85-90 (1995)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Kawata, M.et al.: "Roles of steroid hormones and their receptors in structural organization in the nervous system." Neurosci. Res.24. 1-46 (1995)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Kannan, H.et al.: "Activation of sympathetic outflow by reconbinant human interleukin-1beta in conscious rats." Am. J.Physiol.270. R479-R485 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tanaka, H.et al.: "Biphasic changes in behavioral, endocrine, and sympathetic systems in adjuvant arthritis in Lewis rats." Brain Res. Bull.39. 33-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kannan, H.et al.: "Changes in renal sympathetic nerve activities in the regulation of body fluid balance with special reference to central neuropeptides in conscious rats." Jpn. J.Physiol.46. 111-122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Hanamori, T.et al.: "Fiber types of the lingual branch of the trigeminal nerve, chorda tympani, lingual-tonsillar and pharyngeal branches of the glossopharyngeal nerve, and superior laryngeal nerve and their relation to the cardiovascular responses ion rats." Neurosci. Lett.219. 49-52 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Ishizuka, Y.et al.: "Effects of area postrema lesion and abdominal vagotomy on interleukin-1beta-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat." Neurosci. Lett.223. 57-60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Kannan, H.et al.: "Effects of systemic intgerleukin-1beta administration on daily drinking and renal excretory function in conscious rats." Physiol. Behav.61. 707-715 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Inenaga, K.et al.: "Osmotic modulation in glutamatergic excitatory synaptic inputs to nerons in the supraoptic nucleus of rat hypothalamus in vitro." J.Neuroendocrinol.9. 63-68 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Myozaki, M.et al.: "Induction of autoimmune hepatitis and autoantibodies to liver antigens by neonatal thymectomy in mice." Clin. Exp. Immunol.104. 133-143 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Fujii, S.et al.: "B cell mitogenic activity of house dust mite, Dermatophagoides farinae, antigens." Immunol.Lett.49. 37-42 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Kishi, H.et al.: "Proliferation of retinal pigment epithelial cells by neuropeptides in vitro." Curr. Eye Res.15. 708-713 (1996)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Ueda, S.et al.: "Organization of regenerating serotonergic fibers in the hippocampal formation." Brain Res. Bull.39. 89-99 (1996)

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      「研究成果報告書概要(欧文)」より
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  • [Publications] Pasterkamp, R.J.et al.: "The perinatal ontogeny of estrogen receptor-immunoreactivity in the developing male and female rat hypothalamus." Dev. Brain Res.91. 300-303 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Hu, Z.et al.: "Exposure of postnatal rats to gluboborticoids suppresses the development of cholin acetyltransferase-immunoreactive neurons : role of adrenal steroids in the development of forebrain cholinergic neruons." J.Chem. Neuroanat.10. 1-10 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Morimoto, M.et al.: "Phenotypic alterations of neuropeptide Y,vasoactive intestinal prptide and choline acetyltrandferase in rat cultured chromaffin cells as effecyed by nerve growth factor and glucocorticoid." Arch. Histol.Cytol.59. 205-218 (1996)

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      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Ueda, S.et al.: "Alteration of serotonergic innrvation in the suprachiasmatic nucleus of the rat following removal of input fibers from retina and lateral geniculate nucleus." Neurosci. Lett.211. 97-100 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Yang, M.et al.: "The effects of nerve growth factor on newborn rat dorsal root ganglion neurons in vitro." J.Brain Res.37. 313-317 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Visser, D.T.M.et al.: "The alteration of glucocorticoid receptor-immunoreactivity in the rat forbtain following short-term and long-term adrenalectomy." Brain Res.729. 216-222 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Ueda, S.et al.: "Neuro-glial neurotrophic interaction in the S-100beta retaeded mutant mouse (Polydactyly Nagoya)" Brain Res.738. 15-23 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Morimoto, M.et al.: "Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain : an immunohistochemical and in situ hybridization study." Neurosci. Res.26. 235-269 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Uchimura, D.et al.: "Faciliatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." J.Neuroendocrinol.8. 137-143 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Li, A.-J.et al.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exp. Neurol.137. 318-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Shimizu, N.et al.: "Immunobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat" Am. J.Physiol.271. R537-R544

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Mo, Z.L.et al.: "The effects of IL-1beta on neuronal activities in the dorsaal motor nucleus of the vagus in rat brain slices." Brain Res. Bull.41. 249-255 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Oka, T.et al.: "Intracerebroventricular injection of tumor necrosis factor alpha induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
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      1997 Final Research Report Summary
  • [Publications] Oka, T.et al.: "Inhibition of peripheral interleukin-1-induced hyperalgesia by the intracerebroventricular administration of diclofenac and alpha-melanocyte-stimulating hormone" Brain Res.736. 237-242 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shimizu,K., et al.: "Selective expression of HSP70-1 gene in the adrenal cortex but not in the medull of themally stressed rats" Biochem.Biophys.Res.Commun.233. 550-554 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Inenaga,K., et al.: "Osmotic modullation in glutamatergic excitatory synaptic tnpucts toneurons in the supraoptic nucleus of rat hypothalamus in vitro" J.Neuroendocrinol.9. 63-68 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shibuya, I., et al.: "Both GABA_A and GABA_B neceptors participate in suppression of [Ca^<2+>],pulsing in toad melanorcophs" Eur.J.Pharmacol.321. 241-246 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto,S., et al.: "Parathyroid hormone-related peptide-(1-34)[PTHrP-(1-34)]induces vasopressin release from the rat supraoptic nucleus in vitro throuyh a novel receptor distinct from a type I a type PTH/PTHrP recepeor" Endocrinology. 138. 2066-2072 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hara,Y., et al.: "Increase of urocortin-like immunoreactivity in the hypothalamuo-neuvolypophysial system afterisalt loading and hypognysedomry" Neurosci.Lett.227. 127-130 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto,S., et al.: "C-type natriuretic peptide suppresses arginine-vasopressin secretion from dissaiated magnacllular neurons in newborn rat supraopic nucleus" Neurosci.Lett.229. 97-100 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tokunaga,M., et al.: "PTH-related peptide-like immunoreactivity in the wedian emineuce,paraventriculay and supraoptic nuclei in colhicine-terated rates." Brain Rse.774. 216-220 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Uezono,Y., et al.: "Enhancement by baclofen of Gs-coupled receptor receptor mediated cAMP production in xenopus oocytes expressory rat brain cortex poly(A)^+ RNA:A role of G-protein Br subun" Biochem.Biophys.Res.Commun.241. 476-480 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto,S., et al.: "Centrally administered paruthyroid hormone(PTH)-related protein (1-34)but not PTH(1-34)shimulates arginine vasopressin and its messenger ribonudeic acid expression in supoaoptic nucleus of the cohscious rats" Endocrinology. 139. 383-388 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shibuya,I., et al.: "PACAP increaes the cytosolic Ca^<2+> concentration and stimulates somatodendritic[vasopressin release in rat supraoptic neurons" J.Neuroendocrinol.10. 31-42 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ueta,Y., et al.: "Neuronal nitric oxied synthase gene expression in human pituitury tumars a possible association with somatotron adenolnas and gronlth hormone-reieasug hormone gene expression" Clin.Endocrnol.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka,K., et al.: "PACAP causes Ca^<2+> release from ryanodine/caffeine stores through a novel pathway independent of both IP_3 and cAMP in bovine adrenal medullary cells" J.Neurochem.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Hara,Y., et al.: "Increase of urowotin-like immucro reactivity in the rat supraoptic nucleus after dehydration but not food deprivation" Neurosci.Lett.229. 65-68 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Anai,H., et al.: "Upregulation of the expression of vasopression gene in the paraventricular and supraoptic nuclei of the lithium-induced diabetes insipidus rat" Brain Res.772. 161-166 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka,K., et al.: "Pituitary adenylate cyclase-activating polypeptide poteutiation of Ca^<2+> entry via protein kinase C and A pathways in melanotrophs of the pituitany pars intermedia of rat" Endocrinology. 138. 4086-4095 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nomura,M., et al.: "Water deprivation incveases the expression of pituitary adenylatecyclaseactivating polypeptide gene in the rat subfornical organ" Endocrinology. 138. 4096-4100 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kabashima,N., et al.: "Inhibition of spontaneovs EPSCsand IPSCs by presynaptic GABA_B receptors on rat snpraoptic magnocellular neurons" J.Physiol.(Lond.). 504. 113-126 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamamoto,Y., et al.: "Upregulation of neuronal NOSmRNA in the PVN and SON of inherited diabetes insipidus rats" NeuroReport. 8. 3907-3911 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ueta,Y., et al.: "Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventrcular and supraopric nuclei of rats" Brain Rse.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Hattori,Y., et al.: "Ionotrophic and metabotropic glutamate recepta agonist-induced [Ca^<2+>];increase in isolated rat supraoptic neurones" J.Neuraeudocrinol.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Asada,N., et al.: "Ideutification of α and β cellsin intact isolated islet of Langerhans by their characteristic [Ca^<2+>]c dynamocs and immunocytochewical staining" Diabetes. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Uezono,Y., et al.: "Adrenomedullin increases intracellular Ca^<2+> and inosifol 1,4,S-triphosphate in human oligodendroglial cell line KG-lC." Brain Res.(in press).

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      1997 Annual Research Report
  • [Publications] Uezono,Y., et al.: "Activation of inwardly rectifying K^+ by GABA-B receptors expresses in Xenopud ooztes" NeuroReport. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Harayama,N., et al.: "Inhibition of N-and P/Q-type calcium channels by postsynaphc GABA_B receptor activation in rat supraoptic renrones" J.Physiol,(Lond.). (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Serino,R., et al.: "Upregulation of hypothalgmic nitric oxide synthase gene expression in streptozotocin-induced diabetic rats" Diabetologia. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] Shibuya,I., et al.: "The Adrenal Chromaffin Cell" Hokkaido Llniv.Press, (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yamashita,H.: "The ethics of life" UNESCO, 238 (1997)

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      1997 Annual Research Report
  • [Publications] 山下 博, 他: "循環器科" 科学評論社, (1997)

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      1997 Annual Research Report
  • [Publications] 澁谷 泉, 他: "内分泌・糖尿病科" 科学評論社,

    • Related Report
      1997 Annual Research Report
  • [Publications] 上田陽一, 他: "医学のあゆみ" 医歯薬出版, 102 (1998)

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      1997 Annual Research Report
  • [Publications] Kannan,H.et al.: "Activation of sympathetic outflow by recombinant human interleukin-1β in conscious rats." Am.J.Physiol.270. R479-R485 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tanaka,H.et al.: "Biphasic changes in behavioral,endocrine,and sympathetic systems in adjuvant arthritis in Lewis rats." Brain Res.Bull.39. 33-37 (1996)

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      1996 Annual Research Report
  • [Publications] Knnan,H.et.al.: "Changes in renal sympathetic nerve activities in the regulation of body fluid balance with special reference to central neuropetides in conscious rats." Jpn.J.Physiol.46. 111-122 (1996)

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      1996 Annual Research Report
  • [Publications] Hanamori,T.et al.: "Fiber types of the lingual branch of the trigeminal nerve,chorda tympani,lingual-tonsillar and pharyngeal branches of the glossopharyngeal nerve,and superior laryngeal nerve and their relation to the cardiovascular responses in rats." Neurosci.Lett.219. 49-52 (1996)

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      1996 Annual Research Report
  • [Publications] Ishizuka,Y.et al.: "Effects of area postrema lesion and abdominal vagotomy on interleukin-1β-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat." Neurosci.Lett.(in press). (1996)

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      1996 Annual Research Report
  • [Publications] Kannan,H.et al.: "Effects of systemic interleukin-1β administration on daily drinking and renal excretory function in conscious rats." Physiol.Behav.(in press). (1996)

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      1996 Annual Research Report
  • [Publications] 斉田光彦et al.: "アドレノメデュリンと自律神経活動" 現代医療. 28. 2841-2844 (1996)

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      1996 Annual Research Report
  • [Publications] 花森隆充et al.: "ラット島皮質ニューロンの咽頭・喉頭領域の味刺激に対する応答" 日本味と匂学会誌. 3. 480-483 (1996)

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      1996 Annual Research Report
  • [Publications] Inenaga,K.et al.: "Osmotic modulation in glutamatergic excitatory synaptic inputs to neurons in the supraoptic nucleus of rat hypothalamus in vitro." J.Neuroendocrinol.63 (1997)

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      1996 Annual Research Report
  • [Publications] Myozaki,M.et al.: "Induction of autoimmune hepatitis and autoantibodies to liver antigens by neonatal thymectomy in mice" Clin.Exp.Imm unol.104. 133-143 (1996)

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      1996 Annual Research Report
  • [Publications] Fujii,S.et al.: "B cell mitogenic activity of house dust mite,Dermatophagoides farinae,antigens." Immunol.Letter. 49. 37-42 (1996)

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      1996 Annual Research Report
  • [Publications] Kishi,H.et al.: "Proliferation of retinal pigment epithelial cells by neuropeptides in vitro." Curr.Eye Res.15. 708-713 (1996)

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      1996 Annual Research Report
  • [Publications] Ueda,S.et al.: "Organization of regenerating serotonergic fibers in the hippocampal formation." Brain Res. Bull.39. 89-99 (1996)

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      1996 Annual Research Report
  • [Publications] Pasterkamp R.J.et al.: "The perinatal ontogeny of estrogen receptor-immunorectivity in the depeloping male and female rat hypothalamus." Dev.Brain Res.91. 300-303 (1996)

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      1996 Annual Research Report
  • [Publications] Hu、A.et al.: "Exposure of postnatal rats to glucocorticoids suppresses the development of choline acetyltransferase-immunoreactive neurons : role of adrenal steroids in the development of forebrain cholinergic neurons." J.Chem.Neuroanat.10. 1-10 (1996)

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      1996 Annual Research Report
  • [Publications] Morimoto,M.et al.: "Phenotypic alterations of neuropeptide Y,vasoreactive interstinal peptide and cholone acetyltransferase in rat cultured cromaffin cells as effected by nerve growth factor and glucocorticoid." Arch.Histol.Cytol.59. 205-218 (1996)

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      1996 Annual Research Report
  • [Publications] Ueda,S et al: "Altertion of serotonergic innervation in the suprachiasmatic nucleus of the rat following removal of input fibers from retina and lateral geniculatenucleus." Neurosci.Lett.211. 97-100 (1996)

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      1996 Annual Research Report
  • [Publications] Yang, M.et al.: "The effects of nerve growth factor on newborn rat dosal root ganglion neurons in vitro." J.Brain Res.37. 313-317 (1996)

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      1996 Annual Research Report
  • [Publications] Visser,D.T.M.et al.: "The alteration of glucocorticoid recepter-immunoreactivity in the rat forebrain following short-term and long-term adrenalectomy." Brain Res.729. 216-222 (1996)

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      1996 Annual Research Report
  • [Publications] Ueda,S.et al: "Neuro-glial neurotrophic inteeraction in the S-100β retarded mutant mouse(Polydactyly Nagoya)." Brain Res.738. 15-23 (1996)

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      1996 Annual Research Report
  • [Publications] Morimoto,M et al.: "Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain : an immunohistochemical and in situ hybridization study." Neurosci.Res. 26. 235-269 (1996)

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      1996 Annual Research Report
  • [Publications] 堀哲郎et al.: "発熱の病体生理" Today's Therapy. 20. 115-118 (1996)

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      1996 Annual Research Report
  • [Publications] Uchimura,D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide(PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus(PVN) in vitro.21GC23:J.Neuroendocrinol" 8. 137-143 (1996)

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      1996 Annual Research Report
  • [Publications] Li,A-J: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

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      1996 Annual Research Report
  • [Publications] Shimizu,N: "Immoblization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

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      1996 Annual Research Report
  • [Publications] Mo,Z.L.: "The effects of IL-1β on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res.Bull. 41. 249-255 (1996)

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      1996 Annual Research Report
  • [Publications] Oka,T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

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      1996 Annual Research Report
  • [Publications] Oka,T.: "Inhibition of peripheral interleukin-1-β-induced hyperalgesia by the intracerebroventricular administrationof diclofenac and α-melanocyte-stimulating horm one." Brain Res.736. 237-242 (1996)

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      1996 Annual Research Report
  • [Publications] Oka,K: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of 1L-1β." Am.J.Physiol.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Oka,T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Li,A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] Katafuchi,T.: "Differential effects of tumor necrosis factor-α and-β on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.(in press). (1997)

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      1996 Annual Research Report
  • [Publications] 片渕俊彦: "交感神経による脾臓ナチュラルキラー細胞活性制御の視床下部機序" 自律神経. 33. 267-272 (1996)

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      1996 Annual Research Report
  • [Publications] 岡孝和: "痛みと情動" Clinical Neuroscience. 14. 1025-1027 (1996)

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      1996 Annual Research Report
  • [Publications] 河田光博et al.: "現代の神経内分泌学" 下垂体後葉ホルモンの産生、分布、分泌機能, 179-186 (1996)

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      1996 Annual Research Report
  • [Publications] Hori,T.: "Discussion on Future Directions in Psychoneuroimmunology and Cancer." Nishimura Co.,Ltd.and Smith-Gordon Co.,Ltd., 166 (1996)

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      1996 Annual Research Report
  • [Publications] Hori,T.: "Physiological Basis of Occupational Health : Stressful Environments." SPB Academic Publishing bv, 278 (1996)

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      1996 Annual Research Report
  • [Publications] 堀哲郎: "現代の神経内分泌学" メディカル・サイエンス・インターナショナル, 506 (1996)

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      1996 Annual Research Report
  • [Publications] 堀哲郎: "最新内科学大系、PartI.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)

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      1996 Annual Research Report
  • [Publications] Yamashita, H. et al.: "Chemical control of vasopressin and oxytocin neurons in the supraoptic nucleus" Neurohypophysis: Recent progress of vasopressin and oxytocin research.197-204 (1995)

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      1995 Annual Research Report
  • [Publications] Ueta, Y. et al.: "Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat" Neuroscience Letters. 202. 37-40 (1996)

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      1995 Annual Research Report
  • [Publications] Tanaka, K. et al.: "PACAP causes rapid Ca^<2+> release from intracellular stores and long-lasting Ca^<2+> influx mediated by Na^+ influx-dependent membrane depolarization in bovine adrenal chromaffin cells" Endocrinology. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Inenaga, K. et al.: "GABAergic inhinbitory inputs to subfornical organ neurons in rat slice preparations" Brain Research. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Hori, T. et al.: "The autonomic nervous system as a communication channel between the brain and the immune system" Neuroimmunomedulation. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] Kawata, M.: "Roles of steroid hormones and their receptors in structural organization in the nervous system" Neurosicence Research. 24. 1-46 (1995)

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      1995 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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