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Development of depth dose meter for heavy ion particle beams with piled plastic scintillators

Research Project

Project/Area Number 07507005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section試験
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

INOUE Toshihiro  Osaka University, Medical School, Professor, 医学部, 助教授 (70028512)

Co-Investigator(Kenkyū-buntansha) IKEGAMI Kazunori  Mitsubishi Electric Company Advanced Electrotechnology Department, Chief Stuff, 産業システム研究所, 主幹
OZEKI Syuji  Osaka University, Genome Information Research Center, Assistant Professor, 遺伝情報実験施設, 助手 (80093384)
YAMAMOTO Takayoshi  Osaka University, Radioisotope Research Center, Professor, ラジオアイソトープ総合研究センター, 教授 (30029243)
HATANAKA Kichiji  Osaka University, Research Center for Nuclear Physics, Associate Professor, 核物理研究センター, 助教授 (50144530)
INOUE Takehiro  Osaka University, Medical School, Associate Professor, 医学部, 助教授 (10159981)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsRadiation dosimetry / Depth dose distribution / Particle radiotherapy / Heavy particle / Seintillation fiber / Plastic scintillator
Research Abstract

We continued to test the new developed depth dose meter. The dosimeter was exposed to x rays (4,10 and 18 MV) and electron beams (6,9,12 and 15 MeV) from Linac at the Osaka University Hospital, proton beams (65 and 200 MeV) from the cyclotron at RCNP of Osaka University and carbon beam (290MeV/n) from the Heavy Ion of Medical Accerator in Chiba of NIRS to test it. The pressed type of fiberblock without heat is more suitable for sensor than that with heat in respect of shielding the light. We could decrease the background signal in obtaining the image data by utilizing the digital filter. The fitness was good between the depth dose data by ionization chamber and by new dosimeter after compensating Cerenkov light for X ray and electron beam, quenching of light by energetic proton beams. The discrepancy became smaller by compensating the characteristics of emission of light from fiberblock. We could measure the depth dose curve for mono peak beam of carbon. But the discrepancy was large for spread outed carbon beams containing different components of LET.There are much room for improvement. After confirming the high quality of depth dose meter by correcting the difference of light emission by variable particles, we have a plan to make more compact 3D depth dose meter with rotation and rectilinear motion of detector. Such a new designed dosimeter will be useful because of reducing time for measurement of the fundamental dose distribution.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 井上武宏: "重粒子線深部線量測定装置の試作" 日放腫会誌. 8(suppl 1). 236- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 福島祥子: "陽子線と炭素線照射によるヒトリンパ芽球系細胞でのアポトーシス誘導" 日放腫会誌. 8(suppl 1). 280- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上俊彦: "陽子線・重粒子線治療と小線源治療の対比" 日医放会誌. 56(10). S237- (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上俊彦: "重粒子線照射によるcell cycle arrestに対するp53の関与" 平成7年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書. 105-106 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Murayama, S.: "Construction of the irradiation system for biological and medical use in RCNP (2)." RCNP Annual Report 1994. 69-71 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fukushima,S.: "Cell cycle kinetics and p53 protein induction in human lymphoblast cell lines following exposure to 65 MeV proton beam." RCNP Annual Report 1995. 66-69 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tang, J-T: "Relative biological effectiveness of 65 MeV proton beam comparing with 137Cesium gamma rays at Research Center for Nuclear Physics in Osaka University" Med. J. Osaka Univ. 45. 1-4 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tang, J-T: "Comparisons of radiological effectiveness at different depth in 65 MeV modulated proton beams" Brit. J. Cancer. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tang, J-T: "Differences in repair of potentially lethal damage in chinese hamster ovary cells exposed to 65 MeV proton beams and 137Cesium ν rays" Oncology Reports. 4. 407-412 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fukushima, S: "Induction of p53 protein by carbon ion and proton beam irradiation in two close human lymphoblastoid cell lines with different p53 status" Oncology Reports. 4(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue, Ta.: "Development of the absorbed dose sensor for heavy particle beam." J.Jpn.Soc.Ther.Radiol.8 (suppl 1). 236 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fukushima, S.: "Apotosis induced by proton and carbon-ion beams in human lymphoblastoid cell lines." J.Jpn.Soc.Ther.8 (suppl 1). 280 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue, To.: "Comparison between heavy particle therapy and brachytherapy." Nippon Act.Radiol.56(10). S237 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inoue, To.: "p53 mediated cell cycle arrest after irradiation with heavy ion beam." NIRS-M-108. 105-106 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Murayama, S.: "Construction of the irradiation system for biological and medical use in RCNP (2)." RCNP Annual Report 1994. 69-71 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fukushima, S.: "Cell cycle kinetics and p53 protein induction in human lymphoblast cell lines following exposure to 65 MeV proton beam." RCNP Annual Report 1995. 66-69 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tang, J-T.: "Relative biological effectiveness of 65 MeV proton beam comparing with 137Cesium gamma rays at Research Center for Nuclear Physics in Osaka University." Med.J.Osaka Univ.45. 1-4 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tang, J-T.: "Comparisons of radiobiological effectiveness at different depth in 65 MeV modulated proton beams." Brit.J.Cancer.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Tang, J-T.: "Differences in repair of potentially lethal damage in chinese hamster ovary cells exposed to 65 MeV proton beams and 137Cesium gamma rays." Oncology Reports.4. 407-412 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Fukushima, S.: "Induction of p53 protein by carbon ion and proton beam irradiation in two close human lymphoblastoid cell lines with different p53 status." Oncology Reports.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 井上武宏: "重粒子線深部線量測定装置の試作" 日放腫会誌. 8(suppl 1). 236 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 福島祥子: "陽子線と炭素線照射によるヒトリンパ芽球系細胞でのアポトーシス誘導" 日放腫会誌. 8(suppl 1). 280 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 井上俊彦: "陽子線・重粒子線治療と小線源治療の対比" 日医放会誌. 56(10). S237 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 井上俊彦: "重粒子線照射によるcell cycle arrestに対するp53の関与" 平成7年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書. 105-106 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Murayama,S.: "Construction of the irradiation system for biological and medical use in RCNP(2)." RCNP Annual Report 1994. 69-71 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fukushima,S.: "Cell cycle kinetics and p53 protein induction in human lymphoblast cell lines following exposure to 65 MeV proton beam." RCNP Annual Report 1995. 66-69 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tang,J-T: "Relative biological effectiveness of 65 MeV proton beam comparing with 137Cesium gamma rays at Research Center for Nuclear Physics in Osaka University" Med.J.Osaka Univ. 45. 1-4 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tang,J-T: "Comparisons of radiobiological effectiveness at different depth in 65 MeV modulated proton beams" Brit.J.Cancer. (in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Tang,J-T: "Differences in repair of potentially lethal damage in chinese hamster ovary cells exposed to 65 MeV proton beams and 137Cesium γ rays" Oncology Reports. 4. 407-412 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Fukushima,S: "Induction of p53 protein by carbon ion and proton beam irradiation in two close human lymphoblastoid cell lines with different p53 status" Oncology Reports. 4(in press). (1997)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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