| Project/Area Number |
07555019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Applied optics/Quantum optical engineering
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| Research Institution | Keio University |
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Principal Investigator |
SASAKI Keisuke Keio University, Faculty of Science and Technology, Department of Material Science, Professor, 理工学部, 教授 (00051425)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Kouichi Keio University, School of Medicine, Department of Surgery, Professor, 医学部, 教授 (80051704)
FUJINO Toyomi Keio University, School of Medicine, Department of Surgery, Professor, 医学部, 教授 (20051279)
KOIKE Yasuhiro Keio University, Faculty of Science and Technology, Department of Material Scien, 理工学部, 助教授 (60161840)
MINAMITANI Haruyuki Keio University, Faculty of Science and Technology, Department of Biomedical Eng, 理工学部, 教授 (70051779)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 1996: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1995: ¥8,100,000 (Direct Cost: ¥8,100,000)
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| Keywords | Polymer optical fiber / Photodynamic treatment / Dye laser / Photosensitive material / Oxygene radical / Luminol reaction / Cancer therapy / Cancer Diagnosis |
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| Research Abstract |
Polymer optical fiber amplifier (POFA) is proposed and evaluated and its application is investigated.
Experimentally and theoretically, the basic performance of POFA is studied. It was evaluated experimentally and by the theoretical model that an order of kilo watt of amplified signal and ASE was obtained by an order of hundred millimeter length-POFA at around 600 nm-wavelength. Especially, ASE-POFA requires pumping source only. Thus, the ASE-POFA is promising to be an easy-handling visible optical source. As one of the application of the POFA,optical source for photodynamic diagnosis (PDD) and photodynamic therapy (PDT) is proposed. Generation of the fluorescence an active oxygen from the photosensitizer excited by the POFA is detected and possibility for the PDD and PDT by the POFA is discussed. In addition, microscopic mechanism of the PDT was evaluated experimentally. Cacer killing effect and phenomena of vascular shut down (VSD) was observed for the first time with the Zinc-photosensitizer.
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