| Project/Area Number |
07556117
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Masayuki Hokkaido Univ., Graduate Sch.of Veterinary Medicine, Professor, 大学院・獣医学研究科, 教授 (80036441)
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| Co-Investigator(Kenkyū-buntansha) |
NIIYAMA Masami Rakuno-Gakuen Univ., Sch.of Veterinary Medicine, Professor, 獣医学部, 教授 (70001534)
橋本 晃 北海道大学, 大学院・獣医学研究科, 教授 (70021706)
前出 吉光 北海道大学, 大学院・獣医学研究科, 教授 (40002084)
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1996: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Obesity / Brown adipose tissue / Beta-adrenoceptor / Dogs |
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| Research Abstract |
Obesity is one of the most important risk factors for diabetes and hypertension in the dog, as in man. In this study, to explore an effective pharmacological method for treatment and prevention of obesity in small animal practises, we have examined in dogs anti-obesity effects of an agonist (CL316,243) to beta3-adrenoceptor which activates brown adipose tissue thermogenesis. When CL316,243 was given intravenously to Beagle dogs, plasma free fatty acid level increased promptly and remarakably, indicating a strong lipolytic action of this drug. When the drug was given orally for 5 weeks, body weight and girth length decreased significantly compared with placebo- controls. Biochemical and histological examinations revealed that the adipose tissues of the dogs chronically given the drug had less triglyceride and expressed a specific thermogenic protein (mitochondrial uncoupling protein). These results show that the beta3-adrenocetor agonist has potent lipolytic and thermogenic action and can be used as an anti-obesity drug in the dog.
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