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Development of a new embolic material with superabsorbent polymer microsphere

Research Project

Project/Area Number 07557068
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

NAKAMURA Hironobu  Osaka University Medical School, Professor, 医学部, 教授 (00116071)

Co-Investigator(Kenkyū-buntansha) TOMODA Kaname  Osaka University Medical School, Lecturer, 医学部, 講師 (20237134)
NARUMI Yoshifumi  Osaka University Medical School, Associate Professor, 医学部・付属病院, 助教授 (90273664)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥6,600,000 (Direct Cost: ¥6,600,000)
Keywordsembolization / angiography / embolic material / AVM / neoplasm / 動脈塞栓術 / 塞栓材料 / 高吸水性ポリマー
Research Abstract

EVALUATION OF SUPER ABSORBENT POLYMER
The super absorbent polymer microsphere, sodium acrylate and vinyl alcohol copolymer (SAP-MS) was investigated as an arterial embolic material. The diameter of the particles was exactly calibrated to control the occlusion level. Passage ability through microcatheters was estimated. SAP-MS were sterilized by absolute alcohol and prepared in the vacuum vial for clinical purpose. Acrylate acid polymer sodium salt was simultaneously evaluated for clinical purposes.
ANIMAL STUDIES
Animal studies were done to evalute the embolic effects and histopathologic reaction by the embolization of rabbits kidneys. The follow-up angiographies indicated the total occlusion of embolized renal artery. No recanalization was found after the embolization. The arterial lumen was completely occluded by the SAP-MS which expanded larger than the original diameter of the artery. No reactive changes were found in the arterial wall and perivascular tissue. Extensive fibrosis in the whole renal tissue and calcification mainly in the cortex were found.
CLINICAL RESULTS
Patients with neoplastic lesions were treated by embolotherapy with SAP-MS.In hepatocellular carcionoma, necrotic effects without anti-neoplastic agent were obtained. Preoperative embolization resulted in less invasive surgical interventions. Unsatisfactory necrotic effects was archived in cases of renal cell carcinoma. Metastatic bone tumors were well treated in control of local pain without complications.
Arteriovenous malformations were well controlled by embolization using SAP-MS without any complication, however, the lesions coexisting AV fistula were not managed without combination use of other materials.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 姚 家其, 友田 要, 中村 仁信 他: "新しい動脈塞栓物質-高吸水性ポリマー(SAP-Microsphere)の特性と塞栓効果-" 日本医学放射線学会雑誌. 56巻・1号. 19-24 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 堀 信一, 友田 要, 中村 仁信 他: "高吸水性ポリマーによる動脈塞栓効果の検討" IVR. 11巻・3号. 375-381 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 姚家其, 友田要, 中村仁信 他: "新しい動脈塞栓物質-高吸水性ポリマー(SAP-Microsphere)の特性と塞栓効果-" 日本医学放射線学会雑誌. 56巻・1号. 19-24 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀信一, 友田要, 中村仁信 他: "高吸水性ポリマーによる動脈塞栓効果の検討" IVR. 11巻・3号. 375-381 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀信一: "高吸水性ポリマーによる動脈塞栓効果の検討" 日本血管造影・IVR学会誌(IVR). 11・3. 75-81 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 堀信一: "四肢動静脈奇形の動脈塞栓術" 日本血管造影・IVR学会誌(IVR). 11・3. 29-33 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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