| Project/Area Number |
07557068
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
NAKAMURA Hironobu Osaka University Medical School, Professor, 医学部, 教授 (00116071)
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| Co-Investigator(Kenkyū-buntansha) |
TOMODA Kaname Osaka University Medical School, Lecturer, 医学部, 講師 (20237134)
NARUMI Yoshifumi Osaka University Medical School, Associate Professor, 医学部・付属病院, 助教授 (90273664)
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| Project Period (FY) |
1995 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1997: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥6,600,000 (Direct Cost: ¥6,600,000)
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| Keywords | embolization / angiography / embolic material / AVM / neoplasm / 動脈塞栓術 / 塞栓材料 / 高吸水性ポリマー |
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| Research Abstract |
EVALUATION OF SUPER ABSORBENT POLYMER
The super absorbent polymer microsphere, sodium acrylate and vinyl alcohol copolymer (SAP-MS) was investigated as an arterial embolic material. The diameter of the particles was exactly calibrated to control the occlusion level. Passage ability through microcatheters was estimated. SAP-MS were sterilized by absolute alcohol and prepared in the vacuum vial for clinical purpose. Acrylate acid polymer sodium salt was simultaneously evaluated for clinical purposes.
ANIMAL STUDIES
Animal studies were done to evalute the embolic effects and histopathologic reaction by the embolization of rabbits kidneys. The follow-up angiographies indicated the total occlusion of embolized renal artery. No recanalization was found after the embolization. The arterial lumen was completely occluded by the SAP-MS which expanded larger than the original diameter of the artery. No reactive changes were found in the arterial wall and perivascular tissue. Extensive fibrosis in the whole renal tissue and calcification mainly in the cortex were found.
CLINICAL RESULTS
Patients with neoplastic lesions were treated by embolotherapy with SAP-MS.In hepatocellular carcionoma, necrotic effects without anti-neoplastic agent were obtained. Preoperative embolization resulted in less invasive surgical interventions. Unsatisfactory necrotic effects was archived in cases of renal cell carcinoma. Metastatic bone tumors were well treated in control of local pain without complications.
Arteriovenous malformations were well controlled by embolization using SAP-MS without any complication, however, the lesions coexisting AV fistula were not managed without combination use of other materials.
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