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Development of Magnetite Conjugated to Monoclonal Antibodies for Cancer Diagnosis and Therapy

Research Project

Project/Area Number 07557088
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section試験
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

TAKAHASHI Toshio  Kyoto Prefectural University of Medicine, Surgery, Professor, 医学部, 教授 (50079828)

Co-Investigator(Kenkyū-buntansha) INADA Yuuji  Yokohama University, School of Industry, Professor, 工学部, 教授 (40016035)
YAMAGUCHI Toshiharu  Kyoto Prefectural University of Medicine, Surgery, Associate Professor, 医学部, 助教授 (90111327)
Project Period (FY) 1995 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 1996: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1995: ¥12,500,000 (Direct Cost: ¥12,500,000)
Keywordsmonoclonal antibody / intraoperative diagnosis / colonic cancer / chimeric antibody / 転移 / 磁性体 / 簡中診断 / ハイブリッド / 磁気検出
Research Abstract

Recently, aggressive lymph node dissection in conjunction with resection of main tumor for visceral malignancy has been reported to result in substantial improvements in survival. However, normal organs or lymph nodes without cancer involvment are resected simultaneously with cancerous tissues. It is difficult to differenciate cancerous tissues from normal tissues with CT scan ot MRI.We have developed monoclonal antibody (Mab) A7 against human colon cancer. MAbA7 has been reported to react with 88% of human colonic carcinomas tested. Recently, we also developed human/mouse chimeric Fab fragments of MabA7 (ChA7Fab) using recombinant DNA techniques. In this study, ChA7Fab was labeled with ^<131>I and administered to nude mice bearing human colon cancer. Radioactivities in the small tumors were measured using portable gamma detecting probe (GDP) two days after injection. Radioactivities in the small tumors were able to detected by GDP.In contrast, radioactivity of normal tissue was not detected. If these ideas could be applied to the human with colon cancer, cancerous tissues could be easily differenciated from normal tissues intraoperatively, because GDP is small device and can be used intraoperatively. Furthermore, if magnetite are used insted of ^<131>I and the device which measure the accumulation of mignetite, we will not be exposed to radioactivity.

Report

(3 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • Research Products

    (146 results)

All Other

All Publications (146 results)

  • [Publications] 山口俊晴他: "各種DDS製剤と技術癌のミサイル療法-臨床から" DDSの進歩1995-96. 212-216 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsoji 他: "Effect of splenectomy on surrival following total gastrectomy for gastric cancer" 1st International Gastric Cancer Congress.1181-1185 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "大腸癌-診断と治療の細菌の進歩-診断.モノクローナル抗体による大腸癌診の断" 消化器病セミナー61. 65-76 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "標的療法" 最新癌化学療法. 96-103 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 高橋俊雄他: "幽門側胃切除術" 消化器外科専門医への道. 124-132 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "早期胃癌の術後・長期予後" 内科診療Q&A. 208-209 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "胃切除後の癌の再発" 内科診療Q&A. 210-213 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "免疫療法の展望ミサイル療法" 臨床婦人科産科. 49(7). 864-867 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "癌のミサイル療法-展望と問題点-" カレントテラピー. 13(5). 160-164 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "癌細胞を標的とするターゲティング.モノクローナル抗体(ミサイル療法)" Practical Oncology. 8(2). 12-13 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "消化器癌治療の新たな展開.キメラ抗体を用いたターゲティング療法" 消化器癌. 5(5). 399-402 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "癌細胞を標的とするターゲティング-ミサイル療法(モノクローナル抗体)-" MEDICO. 27(3). 14-17 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "抗体工学と癌治療:抗癌剤結合抗体" Biotherapy. 10(2). 114-120 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "腫瘍マーカーを利用した免疫ミサイル療法" 日本臨床. 54. 208-213 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "癌細胞を標的とする新しい治療法" 日本DDS学会誌. 47. 115-160 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "消化器癌に対する抗体療法" Biotherapy. 10. 1408-1411 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "モノクローナル抗体による大腸癌の診断" 総合臨床. 46. 282-286 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Activated carbon-oriented gastectomy for early gastric cancer" Brit J Surg. 82. 647-649 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Activated-carbon-oriented laparoscopic colectomy." Lancet. 345. 1638-1639 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "Application of monoclonal antibodies to histologic diagnosis of gastpic cancers" Tohoku J Exp Med. 176. 213-218 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer." Pancreas. 10(3). 265-273 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Rapid and accurate method for delineating cancer lesions in laparoscopic colectomy using activated carbon injection." J Surg Oncol.58. 31-34 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Superficial spreading type of early gastric lymphomas." Anticancer Research. 15. 2829-2834 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "The effect of intraverous and intra-tomooral Chemotherapy using a monoclonal antibody-drug conjugate in a xenograft model of pancreatic cancer." Europ J Surg Oncol. 21. 61-65 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K.他: "Total gastrectomy for early gastric cancer" J Surg Oncol. 60. 83-88 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Why do cystic doct clips migrate into the common bile doct?" Lancet. 346. 965-966 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "がんに対する新しい免疫療法.キメラ抗体のがん免疫療法への応用" Biotherapy. 9(1). 47-50 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "キメラ抗体を用いた免疫療法の試み" 外科治療. 72(4). 439-442 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "術後管理とその実際.直腸切断術" 外科治療. 72(5). 779-781 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "消化器癌切除後の補助療法とFOLLOW-UPの実際-われわれのプロトコール胃癌" 消化器外科. 18(3). 291-296 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "早期癌の長期予後" 臨床外科. 50. 1221-1225 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Early gastric lymphoma:a clinicopathologic study of ten patients,literature review,and comparison with early gastric adenocarcinoma." Cancer. 77. 850-857 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "A new technique for providing a wide surgical field for low antertor resection with the autosuture device in a narrow pelvis." Europ J Surg Oncol.22. 1102-1103 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "Applicability of monoclonal antibody fab fragments as a carrier of neocarzinostatin in targeting chemotherapy." J Surg Oncol.61. 149-154 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Clinicopathological analysis of gastric cancer in young adults." Hepato-Gastroenterology. 43. 1273-1280 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Clinicopathological characteristics of gastric cancer in the elderly" Brit J Cancer. 73. 798-802 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin." Brit J Cancer. 74. 597-602 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura K 他: "Early gastric cancer in young adults." Tohoku J Exp Med. 179. 93-100 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "Effects of neocarzinostain-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenogratts." Brit J Cancer. 73. 1178-1182 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji E 他: "End result of simultaneous splonectmy in pationts ordergoing total gastrectomy for gastric carcinoma" Surgery. 120. 41-44 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "BRMとミサイル療法" Biotherapy. 10. 605-609 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "スキルス胃癌の診断と治療" 臨床と研究. 73. 1171-1174 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "抗体を利用した大腸癌の診断とターゲティング療法" 癌と化学療法. 23. 549-553 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "皮膚切開・縫合・抜糸" 外科治療. 74. 596-573 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "脾門リンパ節と脾動脈幹リンパ節の郭清" 外科. 58. 1565-1568 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "残胃癌" 消化器外科. 19(6). 825-827 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E.: "Clinical application of targeting chemotherapy for cancer" Drug Delivery system. 1995-96, Hirosi Mizushima ed., Nakayama-Shoten Co., Tokyo. 212-216 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Takahashi, T., Sawai, K., Yamaguchi, T., Yamane, T., Minato, H., Ohara, M.: "Effect of splenectomy on survival following total gastrectomy for gastric cancer" 1st International Gastric Cancer Congress, Mondizzi Editore, Bologna. 1181-1185 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Colonic Cancer-Advances in diagnosis and therapy-Diagnosis with monoclonal antibody against colona cancer" Seminor for gastroenterology 61, Muto T ed., Health Shuppan Co., Tokyo. 65-76 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Hagiwara, A., Taniguchi, H,Kitamura, K,Otsuji, E.: "Targeting chemotherapy" Recent chemotherapy for cancer, Sibuzaki ed., Medicalview Co., Tokyo. 96-103 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takahashi, T,Yamaguchi, T: "Distal fastrectomy" Kanehara Co., Tokyo. 124-132 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Long term follow up study for early gastric cancer" Roppo Co., Nagoya. 208-209 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Recurrence of gastric cancer after gastrectomy" Roppo Co., Nagoya. 210-213 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Targeting Chemotherapy" Rinsyou Sanfujinnka. 49 (7). 864-867 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E.: "Targeting chemotherapy for cancer" Current therapy. 13 (5). 160-164 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Targeting chemotherapy for cancer with monoclonal antibody" Practical Oncology. 8 (2). 12-13 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E., Kato, M., Yata, Y., Okamoto, K., Nishi, H., Tsuruta, H.: "Targeting cancer chemotherapy using monoclonal antibody" Syoukaki-Gann. 5 (5). 399-402 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Targeting chemotherapy using monoclonal antibody" MEDICO. 27 (3). 14-17 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E.: "Immunoconjugate of anticancer drugs" Biotherapy. 10 (2). 114-120 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E.: "Application of tumor marker for immunotargeting therapy for cancer" Nippon-Rinsyou. 54. 208-213 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E.: "New targeting therapy of cancer" Drug Delivery System. 47. 115-160 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Kitamura, K,Otsuji, E., Takahashi, T: "Treatment of digestive cancer using antibody" Biotherapy. 10. 1408-1411 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Kitamura, K,Otsuji, E., Okamoto K,Takahashi, T,Ushijima, H., Maeda T.: "Diagnosis of colon cancer using monoclonal antibody" Sougourinnsyou. 46. 282-286 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Hagiwara, A., Otsuji, E., Simotsuma, M., Taniguchi, H., Yamaguchi, T,Sawai, K., Takahashi, T.: "Activated carbon-oriented gastrectomy for early gastric cancer" Brit J Surg. 82. 647-649 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamane, T., Shimotsuma, M., Hagiwara, A., Yamaguchi, T.: "Takahashi, T. : Activated-carbon-oriented laparoscopic colectomy" Lancet. 345. 1638-1639 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Kodama, T., Takahashi, T.: "Application of monoclonal antibodies to histologic diagnosis of gastric cancers" Tohoku J Exp Med. 176. 213-218 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Yamaoka, N., Kotani, T., Kato, M., Taniguchi, K., Kitamura, K., Takahashi, T.: "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer" Pancreas. 10 (3). 265-273 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamane, T., Oyama, T., Shimotsuma, M., Hagiwara, A., Yamaguchi, T., Sawai, K., Takahashi, T.: "Rapid and accurate method for delineating cancer lesions in laparoscopic colectomy using activated carbon injection" J Surg Oncol. 58. 31-34 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Okamoto, K., Takahashi, T., Suganuma, H.: "Superficial spreading type of early gastric lymphomas" Anticancer Research. 15. 2829-2834 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Tsuruta, T., Yata, Y., Nishi, H., Okamoto, K., Taniguchi, K., Kato, M., Kotani, T., Kitamura, K., Takahashi, T.: "The effect of intravenous and intra-tumoural chemotherapy using a monoclonal antibody-drug conjugate in a xenograft model of pancreatic cancer" Europ J Surg Oncol. 21. 61-65 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Okamoto, K., Taniguchi, H., Hagiwara, A., Sawai, K., Takahashi, T.: "Total gastrectomy for early gastric cancer" J Surg Oncol. 60. 83-88 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Nakatani, H., Ichikawa, D., Shimotsuma, M., Yamane, T., Takahashi, T.: "Why do cystic duct clips migrate into the common bile duct?" Lancet. 346. 965-966 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E.: "Application of chimeric antibody for cancer immunology" Biotherapy. 9 (1). 47-50 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E., Kato, M., Yata, Y.: "Immunotargeting therapy using chimeric monoclonal antibody" Surg Treatment. 72 (4). 439-442 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Manual of postoperative care-abdominoperineal resection of the rectum" Surg Treatmen. 72 (5). 779-781 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Protcol of follow up study after surgery" Shoukakigeka. 18 (3). 291-296 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Long term follow up of early gastric cancer" Rinsyou-Geka. 50. 1221-1225 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Okamoto, K., Ichikawa, D., Hoshima, M., Taniguchi, H., Takahashi, T.: "Early gastric lymphoma : a clinicopathologic study of ten patients, literature review, and comparison with early gastric adenocarcinoma" Cancer. 77. 850-857 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Sawai, K., Takahashi, T.: "A new technique for providing a wide surgical field for low anterior resection with the autosuture device in a narrow pelvis" Europ J Surg Oncol. 22. 1102-4151 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Tsuruta, H., Yata, Y., Nishi, H., Okamoto, K., Taniguchi, K., Kato, M., Kotani, T., Kitamura, K., Takahashi, T.: "Applicability of monoclonal antibody fab fragments as a carrier of neocarzinostatin in targeting chemotherapy" J Surg Oncol. 61. 149-154 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Yamamoto, K., Ichikawa, D., Taniguchi, H., Hagiwara, A., Sawai, K., Takahashi, T.: "Clinicopathological analysis of gastric cancer in young adults" Hepato-Gastroenterology. 43. 1273-1280 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Yamaguchi, T., Taniguchi, H., Hagiwara, A., Yamane, T., Sawai, K., Takahashi, T.: "Clinicopathological characteristics of gastric cancer in the elderly" Brit J Cancer. 73. 798-802 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Matsumura, H., Yamamoto, K., Tsuruta, H., Yata, Y., Nishi, H., Okamoto, K., Kitamura, K., Takahashi, T.: "Distribution of neocar-zinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin" Brit J Cancer. 74. 597-602 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kitamura, K., Taniguchi, H., Yamaguchi, T., Takahashi, T.: "Early gastric cancer in young adults" Tohoku J Exp Med. 179. 93-100 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Tsuruta, H., Yata, Y., Nishi, H., Okamoto, K., Taniguchi, K., Kato, M., Kotani, T., Kitamura, K., Takahashi, T.: "Effects of neocarzinostain-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts" Brit J Cancer. 73. 1178-1182 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Otsuji, E., Yamaguchi, T., Sawai, K., Ohara, M., Takahashi, T.: "End result of simultaneous splenectmy in patients undergoing total gastrectomy for gastric carcinoma" Surgery. 120. 41-44 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E., Yamooka, N: "Biological response modifier and missile cancer chemotherapy" Biotherapy. 10. 605-609 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Hagiwara, A., Takahashi, T: "Diagnosis and therapy for scirrhous gastric cancer" Rinsyou to Kenkyuu. 73. 1171-1174 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Kitamura, K,Otsuji, E., Kotani, T., Kato, M., Yata, Y., Okamoto, K., Nishi, H., Ichikawa D,Yamamoto, K: "diagnosis and targeting therapy of colorectal cancer using antibody" Jan J Cancer Therapy. 23. 459-553 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Incision and suture of the skin" Surg Ther. 74. 596-573 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T,Sawai, K., Hagiwara, A., Taniguchi, H,Otsuji, E.: "Lymphnodes dissection along splenic artery" Geka. 58. 1565-1568 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yamaguchi, T,Takahashi, T: "Cancer of the remnant stomach" Syoukaki-Geka. 19 (6). 825-827 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 山口俊晴他: "各種DDS製剤と技術 癌のミサイル療法-臨床から" DDSの進歩1995-96. 212-216 (1995)

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      1996 Annual Research Report
  • [Publications] Otsoji他: "Effect of Splenectomy on surrival following total gastrectomy for gastvic cancer." Ist International Gastric Cancer Congress.1181-1185 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "大腸癌-診断と治療の最近の進歩-診断.モノクローナル抗体による大腸癌の診断" 消化器病セミナー61. 65-76 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "標的療法" 最新癌化学療法. 96-103 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 高橋俊雄他: "幽門側胃切除術" 消化器外科専門医への道. 124-132 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "早期胃癌の術後長期予後" 内科診療Q&A. 208-209 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "胃切除後の癌の再発" 内科診療Q&A. 210-213 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "免疫療法の展望ミサイル療法" 臨床婦人科産科. 49 (7). 864-867 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "癌のミサイル療法-展望と問題点-" カレントテラピー. 13 (5). 160-164 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "癌細胞を標的とするターゲティング.モノクローナル抗体(ミサイル療法)" Practical Oncology. 8 (2). 12-13 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "消化器癌治療の新たな展開、キメラ抗体を用いたターゲティング療法" 消化器癌. 5 (5). 399-402 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "癌細胞を標的とするターゲティング-ミサイル療法(モノクローナル抗体)-" MEDICO. 27 (3). 14-17 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "抗体工学と癌治療:抗癌剤結合抗体" Biotherapy. 10 (2). 114-120 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "腫瘍マーカーを利用した免疫ミサイル療法" 日本臨床. 54. 208-213 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "癌細胞を標的とする新しい治療法" 日本DDS学会誌. 47. 115-160 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "消化器癌に対する抗体療法" Biotherapy. 10. 1408-1411 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "モノクローナル抗体による大腸癌の診断" 総合臨床. 46. 282-286 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Activated corbon-oriented gastrectomy for early gastric cancer." Birt J Surg. 82. 647-649 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Activated-carbon-oriented laparoscopic colectoiny." Lancet. 345. 1638-1639 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "Application of manoclonal anitrbadies to histologic diagnosis of gastpic cancers" Tohoku J Exp Med. 176. 213-218 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "Biodistributin of murine and chimeric Fab fragments of the monoclonal antrbody A7 in human pancreatic cancer." Pancreas. 10 (3). 265-273 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Rapid and accurate method for delineating cancer lesions in laparoscopi colectomy vsing activated carbon in jection" J Surg Oncol. 58. 31-34 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Superficial Spreading Type of early gastric lynphomas." Anticancer Research. 15. 2829-2834 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "The effect of intravenous and intra-tomooral chemgtherapy using a monodunal ontrbody-drug conjugate in a xengraft model of pancreatic cancer." Europ J Surg Oncol. 21. 61-65 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Total gastrectomy for early gastric cancer" J Surg Oncol. 60. 83-88 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Why do cystic doct clips migrate into the common bile doct?" Lancet. 346. 965-966 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "がんに対する新しい免疫療法、キメラ抗体のがん免疫療法への応用" Biotherapy. 9 (1). 47-50 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "キメラ抗体を用いた免疫療法の試み" 外科治療. 72 (4). 439-442 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "術後管理とその実際.直腸切断術" 外科治療. 72 (5). 779-781 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "消化器癌切除後の補助療法とFOLLOW-UPの実際-われわれのプロトコール骨癌" 消化器外科. 18 (3). 291-296 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "早期癌の長期予後" 臨床外科. 50. 1221-1225 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Early gastric lymphomo : a clinicopathologic gtudy of ten patrente, literature review, and comparison with early gastric adenocarcinoma." Cancer. 77. 850-857 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "A new technique for providing a wide suraical field for low anterior resection with the autosutre device in a narrow pelvie." Europ J Surg Oncol.22. 1102-1103 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "Applicability of monoclonal antibody fob frajments as a carrier of neocarzinostatin in taraeting chenothwopy" J Sury Oncol. 61. 149-154 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Clinicopathological analysis of gastric ancer in young adlts." Hepato-Gastroenterology. 43. 1273-1280 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Clinicopathological characteristics of gastric cancer in the el derly" Brit J Cancer. 73. 798-802 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "Dtstribution of neocarqinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fvaments after administration of avidtn." Brit J Cancer. 74. 597-602 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kitamura K 他: "Early gastric cancer in young aduits." Tohoku J Exp Med. 179. 93-100 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "Effects of neocarzinostain-chimerrc Fab confogates on the growth of human pancreatic carcinoma kenogratts." Brit J Cancer. 73. 1178-1182 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Otsuji E 他: "End result of stmulraneous splonectmy in pationts ovdergain total gastrectomy for gastric carcrdoma" Surgery. 120. 41-44 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "BRMとミサイル療法" Biotherapy. 10. 605-609 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "スキルス胃癌の診断と治療" 臨床と研究. 73. 1171-1174 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "抗体を利用した大腸癌の診断とターゲティング療法" 癌と化学療法. 23. 549-553 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "皮膚切開・縫合・抜糸" 外科治療. 74. 596-573 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "脾門リンパ節と脾動脈幹リンパ節の郭清" 外科. 58. 1565-1568 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 山口俊晴他: "残胃癌" 消化器外科. 19 (6). 825-827 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] C.Sakakura et al: "Inhibition of colon cancer cell proliferation by antisense oligonucleo-tides targeting the mesenger RNA of the Ki-ras gene." Anti-cancer Drugs. 6. 553-561 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takahashi et al: "Prophylaxis and treatment of peritoneal carcinomatosis:Intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles." World J.Surg.19. 565-569 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E.Otsuji et al: "Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer" Pancreas. 10(3). 265-273 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] E.Otsuji et al: "The effect of intravenous and intra-tumoural chemotherapy using a monoclonal antibody-drug conjugate in a xenograft model of pancreatic cancer" Europ.J.Surg.Oncology. 21. 61-65 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Takahashi et al: "Role of peritoneal Lymphatics for peritoneal metastasis and chemotherapy with mitomycin C bound to activated carbon particles" Acta Chir.Austriaca. 2. 76-78 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] J.S.Lee et al: "Safety and efficacy of intraperitoneal injection of etoposide in oil suspension in mice with peritoneal carcinomatosis." Cancer Chemother Pharmacy. 36. 211-216 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Imanishi et al: "1st Int.Gastric cancer congress" Intraperitoneal cisplatin microspheres for the treatment of malignant ascites induced by gastric cancer., 4 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Hagiwara et al: "1st Int.Gastric cancer congress" Endoscopic injetion of methotrexate bound to activated carbon particles for the treatment of gastric cancer,a pilot study., 4 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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