| Project/Area Number |
07557111
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KINOSHITA Shigeru Kyoto Prefectural University of Medicine, Ophthalmology, Professor, 医学部, 教授 (30116024)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAWA Takashi Fujitsu Laboratories, Senior Scientist, 主管研究員
SUGIYAMA Yuichi Biophotonics Information Laboratories Ltd., Associate Scientist, 主任研究員
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| Project Period (FY) |
1995 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 1996: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1995: ¥6,300,000 (Direct Cost: ¥6,300,000)
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| Keywords | light scattering / tomography / cornea / sclera / Michelson interferometer / optical coherence tomography / 断層線撮影 |
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| Research Abstract |
We established a prototype device of optical coherence tomography for ophthalmologic application in order to obtain noninvasively high-resolution tomographic images of anterior part of eyes. This device was built by the Michelson's theory using low-coherence infrared light. First, we investigated the most appropriate engineering set-up regarding light pass, super luminescent diode, beam-splitter, mirror etc., for this device, and finally achieved the depth resolution under 9 mum and the detectable level over 100 dB.After numerous improvements in the prototype device, we applied this to pig corneas to obtain A-mode images. A-mode images disclosed fine corneal structures, and the corneal thickness measured by this device was well correlated with that of ultrasonic pachometry. We further obtained fine B-mode images manually from central corneas with or without epithelium. Thus, we could differentiate abraded corneas from normal corneas using this device. The corneo-scleral junctional area showed a gradual change of scattering lights from corneal to scleral side. As a result, we have obtained almost all technical information regarding optical coherence tomography for the anterior segment of the eye. Therefore, we are now planning to make a second generation of optical coherence tomography for clinically applying human corneas and scleras.
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