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Establishment of the analytical system on a fine volume synovial fluid in the human temporomandibular joint

Research Project

Project/Area Number 07557127
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Surgical dentistry
Research InstitutionYamagata University

Principal Investigator

SHIBATA Takanori  Yamagata University, School of Medicine, Department of Dentistry and Oral Surgery, Associate Professor, 医学部, 助教授 (60147220)

Co-Investigator(Kenkyū-buntansha) MIYASAKI Kyosuke  Seikagaku Kogyo Co., 医薬事業部学術課, 研究員
KUBOTA Eiro  Kanagawa Dental College, Second Department of Oral and Maxillofacial Surgery, Pr, 歯学部, 教授 (50170030)
FUJITA Shigeyuki  Kyoto University, Faculty of Medicine, Department of Oral and Maxillofacial Surg, 医学部, 講師 (50228996)
MURAKAMI Ken-Ichiro  Kyoto University, Faculty of Medicine, Department of Oral and Maxillofacial Surg, 医学部, 助教授 (00174269)
YOSHIDA Kazuya  Kyoto University, Faculty of Medicine, Department of Oral and Maxillofacial Surg (90263087)
Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 1997: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1996: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1995: ¥6,600,000 (Direct Cost: ¥6,600,000)
KeywordsTemporomandibular joint / Synovial fluid / Synovial fluid analysis / a fine volume Analysis / Osteoarthritis / Diagnosis on synovial fluid / Inflammatory markers / Cartilage degradation markers / 滑液分析 / 滑液検査法 / 滑液マーカー
Research Abstract

1) Interleukin 1beta levels in synovial fluid of the TMJ have a positive correlation with OA change. The Stromelysin (MMP3) activity detected was greatly increased in patients with cartilage degradation. These changes may be important markers of early bone deterioration in TMJ_s that are undetectable by radiograph imaging.
2) Concomitant increases in the level of cytokines (IL-1 and IL-6) and active forms of MMP_s could be potential catabolic markers for cartilage degradation in the TMJ.
3) The PGE_2 level in the TMJ synovial fluid does not specifically reflect the intensity of pain or synovitis, but the detection of high concentrations of C4S and C6S,compared to the amount of HA,is a possible marker of proteoglycan degradation in the TMJ.
4) The ratio of concentrations of C4S and C6S in the synovial fluid of the TMJ reflect the proteoglycan metabolism of the joint tissues, particularly of the articular cartilage and synovial tissue. This ratio could be used to diagnose joint diseases and to predict articular cartilage destruction or synovial proliferation due to these diseases.
5) Aspiration should be repeated at least 5 times in order to remove high molecular weight substances from synovial fluid. However, when the intraarticular pathology is more complex, adequate removal of high molecular weight substances can not be achieved, even when aspiration is repeated 9 times.
6) Our modified direct aspiration technique is both logical and will yield the highest success rate possible when attempting direct aspiration of TMJ synovial fluid.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 溝口 智子, 他: "顎関節症のMR画像におけるjoint effusion像の研究 第1報 effusion像の出現頻度とその局在" 日本顎関節学会雑誌. 7. 81-94 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.T.Clark, 他: "A suggested 5 year research agenda for temporomandibular disorders" 日本顎関節学会雑誌. 8. 141-165 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] E., Kubota.et al: "Interleukin l β and Stromelysin(MMP3)Activity of synovial fluid as Possible Markers of osteoarthritis in the TMJ" J.Oral Maxillofac Surg. 55. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] E., Kubota: "Synovial Fluid Cytokines and Protenases as Markers of Temporo mandibular Joint Pisease" J.Oral Maxillofac Surg. 56. 192-198 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K., Murakami et.al: "Intra-articular level of Prostaglandin E_2,Hyaluronicacid dondroitin-4 and -6 sulfates in the TMJ synovial fluid" J.Oral Maxillofac Surg.56. 199-203 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T., Shibata et al.: "Glycosaminoglican compornents in TMJ Synovial fluid as markers of joint pathology" J.Oral Maxillofac Surg. 56. 209-213 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] G.T.Clark: "A suggested 5 year research agenda for temporomandibular disorders." Journal of Japanese Society for Temporomandibular Joint. 8. 141-165 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] E.Kubota: "Interleukin 1beta and Stromelysin (MMP3) Activity of Synovial Fluid as Possible Markers of Osteoarthritis in the Temporomandibular Joint." J Oral Maxillofac Surg. 55. 20-27 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Shibata: "Glycosaminoglycan (GAG_s) components in TMJ synovial fluid as markers of joint pathology." Proceedings of the 2nd Chinese National Symposium of Temporomandibular Disorders. 6-9 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] E.Kubota: "Synovial Fluid Cytokines and Proteinases as Markers of Temporomandibular Joint Disease." J Oral Maxillofac Surg. 56. 192-198 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] K.Murakami: "Intra-articular Levels of Prostaglandin E_2, Hyaluronic Acid, and Chondroitin-4 and -6 sulfates in the TMJ Synovial Fluid of Patients with Internal Derangement." J Oral Maxillofac Surg. 56. 199-203 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] T.Shibata: "Glycosaminoglycan Components in TMJ Synovial Fluid as Markers of Joint pathology." J Oral Maxillofac Surg. 56. 209-213 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] 溝口智子、 他: "顎関節症のMR画像におけるjoint effusion像の研究第1報 : effusion像の出現頻度とその局在" 日本顎関節学会雑誌. 7. 81-94 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] G. T. Clark et al: "A suggested 5 year research agenda for temporomandibular disorders" 日本顎関節学会雑誌. 8. 141-165 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] E.Kubota et al: "Interleukin 1β and Stromelysin(MMP3)Activity of Synovial Fluid as Possible Markers of Osteoarthritis in the Temporomandibular Joint." J. Oral Maxillofac Surg. 55. 20-27 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] E. Kubota et al: "Synovial Fluid Cytokines and Proteinases as Markers of Temporomandibular Joint Disease." J. Oral Maxillofac Surg. 56. 192-198 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] K. Murakami et al: "Intra-articular level of Prostaglandin E_2, Hyaluronic acid, Chondroitin-4 and -6 sulfates in the TMJ synovial fluid in patients with internal derangemnet." J. Oral Maxillofac Surg. 56. 199-203 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] T. Shibata et al: "Glycosaminoglycan componets in TMJ synovial fluid as markers of joint pathology" J. Oral Maxillofac Surg. 56. 209-213 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Eiro Kubota: "Interleukin 1β and Stomelysin(MMP3)" J.Oral and Maxillofacial Surgery. 55. 20-27 (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hideo Imamura: "Synovial fluid Cytokines(1L-1β,1L-6and IL-8)as possible markers of inflammation in the Temparomondibular Joint" Oral Surg.Oral Medicine,Oral Pathology. 83. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] KenIchiro Murakami: "Intraarticular level of Prostaglandin E2,Hyaluronic acid,chondroitin-4and 6 sulfates in the TMJ Synovial" Oral Surg.Oral Medicine,Oral Pathology. 83. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takanori Shibata: "GAG Components in TMJ Synovial Fluid as Markers of Cartilage Degeneration" J.Oral and Maxillofacial Surgery. 55. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Eiro Kubota: "Synovial Fluid Cytokines and Proteinases as Markers of TMJ Disease" J.Oral and Maxilofacial Surgery. 55. (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Takanori Shibata: "Interleukin 1β and storomelysin(MM3)Activity of synovialfluid" Journal of Oral and Maxillofacial Surgery. 54. (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takanori Shibata: "Synovial fluid Cytocaine(IL-1β,IL-6,IL-8)in the Tomporomandibulan" International of Oral and Maxillofacial Surgery. 25. (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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