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Identification of the active domain of insect antibacterial proteins and production of new antibacterial peptides.

Research Project

Project/Area Number 07557152
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

NATORI Shunji  The University of Tokyo Faculty of Pharmaceutical Sciences, Professor, 大学院・薬学系研究科, 教授 (50012662)

Project Period (FY) 1995 – 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 1997: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1996: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1995: ¥3,700,000 (Direct Cost: ¥3,700,000)
Keywordsantibacterial peptide / insect / MRSA / defense / active domain / alpha-helix / α-ヘリックス / 活性ドメイン
Research Abstract

An antibacterial peptide, KLKLLLLLKLK-NH_2 (L5) showed significant chemotherapeutic activity in MRSA-infected mice in vivo. The antibacterial mechanisms of L5 were investigated. L5 was shown to have the activity to release the proton gradient using the bacterial membrane. The strength of the activity of L5 was between CCCP and DNP.And L5 was also shown to inhibit the activity of signal peptidase. Thus these effects of L5 seem to be the main reason of the antibacterial activity. Recently we found that L5 activated the human neutrophil, resulting the production of superoxide. Neither KLKLLLLKLK-NH_2 (L4), nor KLKLLLKLK-NH_2 (L3) has the activity at all, indicating that the number of Leu is important for activating neutrophil.

Report

(4 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • 1996 Annual Research Report
  • 1995 Annual Research Report
  • Research Products

    (67 results)

All Other

All Publications (67 results)

  • [Publications] Yuki Nakajima: "Chemotherapeutic activity of synthetic antimicrobial peptides:correlation between chemotherapeutic activity and neutrophil-activating activity" FEBS Lettcrs. 415. 64-66 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shohei Hori: "Monoclonal Antibodies against Pupa-Specific surface Antigens of Sarcophga peregrina(Flesh Fly) Hemocytes" B.B.R.C.236. 497-501 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mariko Hijikata: "Inhibition of Protein Tyrosine Kinase by 5-S-GAD,a Novel Antibacterial Substance from an Insect" B.B.R.C.237. 423-426 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Makoto Shimoaraiso: "Identification of the Region in Yeast S-II that Defines Species Specificity in its Interaction with RNA polymerase II" J.Biol.Chem.272(42). 26550-26554 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takekazu Kunieda: "Regeneration of Sarcophaga Imaginal Discs in Vitro:Implication of 20-Hydroxyecdysone" Developmental Biology. 183. 86-94 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yuki Nakajima: "A Novel Protease in the Pupal Yellow Body of Sarcophaga peregrina(Flesh Fly)" J.Biol.Chem.272(38). 23805-23810 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shunji Natori: "Molecular Mechanisms of Immune Responses in Insects" Chapman & Hall, 325 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sung Ook Chung, Takeo Kubo and Shunji Natori: "Molecular cloning and sequencing of arylphorin-binding protein in protein granules of the Sarcophaga fat body" J.Biol.Chem.270. 4624-4631 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] So Young Lee, Hyun Joo Moon, Shun-ichiro Kawabata, Shoichiro Kurata, Shunji Natori and Bok Luel Lee: "A sapecin homologue of Holotrichia diomphalia : purification, sequencing and determination f disulfide pairs" Biol.Pharm.Bull.18. 457-459 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jae I1 Kim, Hideo Iwai, Shoichiro Kurata, Masami Takahashi, Katsuyoshi Masuda, Ichio Shimada, Shunji Natori, Yoji Arata and Kazuki Sato: "Structure and function of sapecin B,a peptide blocker of potassium channels" In Peptide Chemistry 1994 (M.Ohno ed.). 45-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takeshi Kurama, Shoichiro Kurata and Shunji Natori: "Molecular characterization of an insect transferrin and its selective incorporation into eggs during oogenesis" Eur.J.Biochem.228. 229-235 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Toshiyuki Nakanishi, Makoto Shimoaraiso, Takeo Kubo and Shunji Natori: "Structure-function relationship of yeast S-II terms of stimulation of RNA polymerase II,arrest relief, and suppression of 6-azauracil sensitivity" J.Biol.Chem.270. 8991-8995 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hideaki Kobayashi, Shoichiro Kurata and Shunji Natori: "Purification of a 200 kDa protein-binding protein from the fat body of Sarcophaga peregrina larvae" Insect Biochem.Molec.Biol.25. 393-399 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Juan Alvarez-Bravo, Shoichiro Kurata and Shunji Natori: "Mode of action of an antibacterial peptide, KLKLLLLLKLK-NH_2" J.Biochem.117. 1312-1316 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Se-Rok Lee, Shoichiro Kurata and Shunji Natori: "Molecular cloning of cDNA for sapecin B,an antibacterial protein of Sarcophaga, and its detection in larval brain" FEBS Letters. 368. 485-487 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] So Young Lee, Hyun Joo Moon, Shoichiro Kurata, Shunji Natori and Bok Luel Lee: "Purification and cDNA cloning of an antifungal protein from the Hemolymph of Holotrichia diomphalia larvae" Biol.Pharm.Bull.18. 1049-1053 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mayumi Nakanishi-Matsui, Takeo Kubo and Shunji Natori: "Molecular cloning and nuclear localization of ATBP,a novel (A+T) -stretch-binding of Sarcophaga peregrina (flesh fly)" Eur.J.Biochem.230. 396-400 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shizu Takeda, Kiyoshi Kita, Hideyo Miyazaki, Shunji Natori and Kazuhisa Sekimizu: "Purification of low-molecular-weight GTP-binding proteins structurally related to MTG33, a mitochondrial GTP-binding protein of Ehrilich ascites tumor cells" J.Biochem.118. 791-795 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tamaki Yano, Noboru Takahashi, Shoichiro Kurata and Shunji Natori: "Regulation of the expression of cathepsin B in Sarcophaga peregrina (flesh fly) at the translational level during metamorphosis" Eur.J.Biochem.234. 39-43 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shunji Natori: "Drosophila counterpart of Sarcophaga lectin" Molecular Mechanisms of Insect Metamorphosis and Diapause. 195-203 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takeo Kubo, Masami Sasaki, Jun Nakamura, Hiromi Sasagawa, Kazuaki Ohashi, Hideaki Takeuchi and Shunji Natori: "Change in the expression of hypopharyngeal-gland proteins of the worker honeybees (Apis mellifera L.) with age and/or role" J.Biochem.119. 291-295 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Hiromi Sugiyama, and Shunji Natori: "Transmethylation reaction is essential for Sarcophaga lectin gene activation" J.Biochem.119. 354-359 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuaki Ohashi, Miyuki Sawata, Hideaki Takeuchi, Shunji Natori and Takeo Kubo: "Molecular cloning of cDNA and analysis of expression of the gene for alpha-glucosidase from the hypopharyngeal gland of the honeybee (Apis miellifera L.)" Biochem.Biophys.Res.Commun.221. 380-385 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takahiro Ito, Qihong Xu, Hideaki Takeuchi, Takeo Kubo and Shunji Natori: "Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor S-II" FEBS Lett.385. 21-24 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kiyoshi Kawasaki, Takeo Kubo and Shunji Natori: "Presence of the Periplaneta lectin-related protein family in the American cockroach (Periplaneta americana)" Insect Biochem.Molec.Biol.26. 355-364 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ko-ichi Homma, Takefumi Matsushita and Shunji Natori: "Purification, characterization, and cDNA cloning of a novel growth factor from the conditioned medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina (flesh fly)" J.Biol.Chem.271. 13770-13775 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Jae Yoon Leem, Chiaki Nishimura, Shoichiro Kurata, Ichio Shimada, Ayako Kobayashi and Shunji Natori: "Purification and characterization of N-beta-Alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophga peregrina (flesh fly)" J.Biol.Chem.271. 13573-13577 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tomohiro Horio, Takeo Kubo and Shunji Natori: "Purification and cDNA cloning of the alcohol dehydrogenase of the flesh fly Sarcophaga peregrina A structural relationship between alcohol dehydrogenase and a 25-kDa protein" Eur.J.Biochem.237. 698-703 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shafiqal Huq, Takeo Kubo, Shoichiro Kurata, Ayako Kobayashi and Shunji Natori: "Purification, characterization, and cDNA cloning of a galactose-specific c-type lectin from Drosophila melanogaster" J.Biol.Chem.271. 20213-20218 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiyuki Sekizawa, Naoshi Ohta, Shunji Natori and Hideshi Kobayashi: "Immunocytochemical localization of lysenin, a novel protein isolated from the coelomic fluid of the earthworm Eisenia foetida" Biomedical Research. 17. 327-330 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Ko-ichi Homma and Shunji Natori: "Identification of substrate proteins for cathepsin L that are selectively hydrolyzed during the differentiation of imaginal discs of Sarcophaga peregrina" Eur.J.Biochem.240. 443-447 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takeo Kubo, Toshimitsu Arai, Kiyoshi Kawasaki and Shunji Natori: "Insect lectins and epimorphosis" Trends in glycoscience and glycotechnology. 8. 357-364 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nobuaki Adachi, Takeo Kubo and Shunji Natori: "Purification, characterization, and cDNA cloning of ABP-2 (arylphorin gene-specific binding protein-2) that specifically binds to the ABP-1-binding sequence in the arylphorin gene of Sarcophaga peregrina" J.Biochem.120. 1239-1246 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yutaka Hirakura, Juan Alvarez-Bravo, Shoichiro Kurata, Shunji Natori and Yutaka Kirino: "Selective interaction of synthetic antimicrobial peptides derived from sapecin B with lipid bilayrs" J.Biochem.120. 1130-1140 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Takekazu Kunieda, Shoichiro Kurata and Shunji Natori: "Regeneration of Sarcophaga imaginal discs in vitro : Implication of 20-hydroxyecdysone" Dev.Biol.183. 86-94 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shunji Natori and Takeo Kubo: "Role of lectins in development and morphogen in insects" New Direction in Invertebrate Immunology. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sumio Ohtsuki, Ko-ichi Homma, Shoichiro Kurata and Shunji Natori: "Molecular cloning of cDNA for Sarcophaga prolyl endopeptidase and charactrization of the recombinant enzyme produced by an E.coli expression system" Insect.Biochem.Molec.Biol.27. 337-343 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Sumio Ohtsuki, Ko-ichi Homma, Shoichiro Kurata and Shunji Natori: "Nuclear localization and involvement in DNA synthesis of Sarcophaga prolyl endopeptidase" J.Biochem.121. 1176-1181 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Tamaki Yano, Ayako Kobayashi, Shoichiro Kurata and Shunji Natori: "Purification and characterisation of cathepsin B mRNA 3'-untranslated-region-binding protein (CBBP), a protein that represses cathepsin B mRNA translation" Eur.J.Biochem.245. 260-265 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Shohei Hori, Ayako Kobayashi and Shunji Natori: "Monoclonal antibodies against pupa-specific surface antigens of Sarcophaga peregrina (flesh fly) hemocytes" Biochem.Biophs.Res.Commun.236. 497-501 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yuki Nakajima, Yumiko Tsuji, Ko-ichi Homma and Shunji Natori: "A novel protease in the pupal yellow body of Sarcophaga peregrina (flesh fly)" J.Biol.Chem.272. 23805-23810 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Mariko Hijikata, Ayako Kobayashi, Jae Yoon Leem, Hidesuke Fukasawa, Yoshimasa Uehara and Shunji Natori: "Inhibition of protein tyrosine kinase by 5-S-GAD,a novel antibacterial substance from an insect" Biochem.Biophs.Res.Commun.237. 423-426 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yuki Nakajima, Juan Alvarez-Bravo, Jang-Hyun Cho, Ko-ichi Homma, Shiro Kanegasaki and Shunji Natori: "Chemotherapeutic activity of synthetic antimicrobial peptides : Correlation between chemotherapeutic activity and neutrophil-activating activity" FEBS Lett.415. 64-66 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Makoto Shimoaraiso, Toshiyuki Nakanishi, Takeo Kubo and Shunji Natori: "Identification of the region in yeast S-II that defines species specificity in its interaction with RNA polymerase II" J.Biol.Chem.272. 26550-26554 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yoshiyuki Sekizawa, Takeo Kubo, Hideshi Kobayashi, Terumi Nakajima and Shunji Natori: "Molecular cloning of cDNA for lysenin, a novel protein in the earthworm Eisenia foetida that causes contraction of rat vascular smooth muscle" Gene. 191. 79-102 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kazuaki Ohashi, Shunji Natori and Takeo Kubo: "Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L." Eur.J.Biochem.249. 797-802 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Azusa Kamikouchi, Hideaki Takeuchi, Miyuki Sawata, Kazuaki Ohashi, Shunji Natori and Takeo Kubo: "Preferential expression of the gene for a putative inositol 1,4,5-trisphosphate receptor homologue in the mushroom bodies of the brain of the worker honeybee Apis mellifera L." Biochem.Biophs.Res.Commun.242. 181-186 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masaji Okamoto, Ichiro Mitsuhara, Masahiro Ohshima, Shunji Natori and Yuko Ohashi: "Enhanced expression of an antimicrobial peptide Sarcotoxin IA by GUS Fusion in Transgenic Tobacco Plants" Plant Cell.Physiol.39. 57-63 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Yuki Nakajima: "Chemotherapeutic activity of synthetic antimicrobial peptides : correlation between chemotherapeutic activity and neutrophil-activating activity" FEBS Letters. 415. 64-66 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shohei Hori: "Monoclonal Antibodies against Pupa-Specific Surface Antigens of Sarcophga peregrina (Flesh Fly) Hemocytes" B.B.R.C.236. 497-501 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mariko Hijikata: "Inhibition of Protein Tyrosine Kinase by 5-S-GAD,a Novel Antibacterial Substance from an Insect" B.B.R.C.237. 423-426 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Makoto Shimoaraiso: "Identification of the Region in Yeast S-II that Defines Species Specificity in its Interaction with RNA Polymerase II" J.Biol.Chem.272(42). 26550-26554 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takekazu Kunieda: "Regeneration of Sarcophaga Imaginal Discs in Vitro : Implication of 20-Hydroxyecdysone" Developmental Biology. 183. 86-94 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yuki Nakajima: "A Novel Protease in the Pupal Yellow Body of Sarcophaga peregrina (Flesh Fly)" J.Biol.Chem.272(38). 23805-23810 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shunji Natori: "Molecular Mechanisms of Immune Responses in Insects" Chapman & Hall, 325 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahiro Ito: "Spermatocyte-specific expression of the gene for mouse testis-specific transcription elongation factor s-II" FEBS Letters. 38385. 21-24 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kiyoshi Kawasaki: "Presence of the Periplaneta Lectin-related Protein Family in the American Cockroach Periplaneta americana" Insect Biochem.Molec.Biol.26. 355-364 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ko-ichi Homma: "Identification of substrate protein for cathepsin L that are selectively hydrolyzed during the defferentiation of imaginal discs of Sarcophaga peregrina" Eur.J.Biochem.240. 443-447 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yutaka Hirakura: "Selective interaction of synthetic antimicrobial peptides derives from sapecin B with lipid bilayers" J.Biochem.120. 1130-1140 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shafiqul Haq: "Purification,characterization,and cDNA cloning of a galactose-specific C-type lectin from Drosophila melanogaster" J.Biol.Chem.271. 20213-20218 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Yoshiyuki Sekizawa: "Immunocytochemical localization of lysenin,a novel protein isolated form the coelomic fluid of the earthworm Eisenia foetida" Biomed.Res.17. 327-330 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shunji Natori: "New Directions in Invertebrate Immunology" SOS Publications, 494 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Juan Alvarez-Bravo: "Mode of action of an antibacterial peptide, KLKLLLLLKLK-NH_2" J. Biochem.117. 1312-1316 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Se-Rok Lee: "Molecular cloning of cDNA for sapecin B, an antibacterial protein of Sarcophaga, and its detection in larval brain" FEBS Letts.369. 485-487 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 名取俊二: "昆虫の抗菌性タンパク質の生産と利用" 植物防疫. 49. 449-453 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 名取俊二: "昆虫の抗菌性蛋白と医薬への応用" 日本臨床. 53. 241-248 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 名取俊二: "昆虫の生体防御タンパク質の改変と利用" 化学と生物. 33. 629-631 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1995-04-01   Modified: 2016-04-21  

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